US5011839A
Expired / Lapsed
US
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3(2H)pyridazinones for antagonistic agent against srs-a
Assignee: Nissan Chemical Corp
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Filing: 1989-12-04
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Granted: 1991-04-30
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Expires: 2009-12-04
Abstract
Abstract A 3(2H)pyridazinone of the formula: ##STR1## wherein R 1 is hydrogen, 2-propenyl, or straight chained or branched C 1 -C 4 alkyl; each of R 2 and R 3 which may be the same or different, is hydrogen, or straight chained or branched C 1 -C 3 alkyl; X is chlorine, or bromine; Y is hydrogen, halogen, nitro, amino, or --AR 4 wherein A is oxygen, or sulfur, and R 4 is hydroen, straight chained, branched or cyclic C 1 -C 8 alkyl, ##STR2## wherein R 5 is hydrogen, or straight chained or branched C 1 -C 4 alkyl; and Ar is ##STR3## wherein each Z 1 and Z 2 which may be the same or different, is hydrogen, halogen, straight or branched C 1 -C 4 alkyl, or --OR 6 wherein R 6 is straight or branched C 1 -C 4 alkyl, and B is oxygen, sulfur, or --N═C-- (to form a quinoline or pyridine ring); or a pharamaceutically acceptable salt thereof.
Inventors
- 👤 Keizo Tanikawa
- 👤 Ryozo Saloda
- 👤 Sakuya Tanaka
- 👤 Kenichi Shikada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 14:31
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/12; A; A61; A61P; A61P11/00; A61P27/00; A61P27/16; A61P29/00; A61P37/00; A61P37/08; A61P9/00; A61P9/08; A61P9/10; C07D237/00; C07D237/02; C07D237/06; C07D237/10; C07D237/22; C07D405/00; C07D405/02; C07D405/12; C07D409/00; C07D409/02; C07D409/12
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
165 words
A 3(2H)pyridazinone of the formula: ##STR320## wherein R 1 is hydrogen, 2-propenyl, or straight chained or branched C 1 -C 4 alkyl; each of R 2 and R 3 which may be the same or different, is hydrogen, or straight chained or branched C 1 -C 3 alkyl; X is chlorine, or bromine; Y is hydrogen, halogen, nitro, amino, or --AR 4 wherein A is oxygen, or sulfur, and R 4 is hydrogen, straight chained, branched or cyclic C 1 -C 8 alkyl, or ##STR321## wherein R 5 is hydrogen, or straight chained or branched C 1 -C 4 alkyl; and Ar is ##STR322## wherein each of Z 1 and Z 2 which may be the same or different, is hydrogen, halogen, straight or branched C 1 -C 4 alkyl, or --OR 6 wherein R 6 is straight or branched C 1 -C 4 alkyl, and B is oxygen, sulfur, or --N═C-- (to form a quinoline or pyridine ring); or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
165 words
A 3(2H)pyridazinone of the formula: ##STR320## wherein R 1 is hydrogen, 2-propenyl, or straight chained or branched C 1 -C 4 alkyl; each of R 2 and R 3 which may be the same or different, is hydrogen, or straight chained or branched C 1 -C 3 alkyl; X is chlorine, or bromine; Y is hydrogen, halogen, nitro, amino, or --AR 4 wherein A is oxygen, or sulfur, and R 4 is hydrogen, straight chained, branched or cyclic C 1 -C 8 alkyl, or ##STR321## wherein R 5 is hydrogen, or straight chained or branched C 1 -C 4 alkyl; and Ar is ##STR322## wherein each of Z 1 and Z 2 which may be the same or different, is hydrogen, halogen, straight or branched C 1 -C 4 alkyl, or --OR 6 wherein R 6 is straight or branched C 1 -C 4 alkyl, and B is oxygen, sulfur, or --N═C-- (to form a quinoline or pyridine ring); or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
71 words
The 3(2H)pyridazinone according to claim 1, wherein Ar is ##STR323## wherein each of Z 1 and Z 2 which may be the same or different, is hydrogen, halogen, straight chained or branched C 1 -C 4 alkyl, or --OR 6 (wherein R 6 is straight chained or branched C 1 -C 4 alkyl, and B is oxygen, sulfur, and --N═C-- (to form a pyridine ring), or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
17 words
The 3(2H)pyridazinone according to claim 1, wherein R 3 is hydrogen, or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
54 words
The 3(2H)pyridazinone according to claim 3, wherein Y is hydrogen, halogen, nitro, amino, or --OR 4 wherein R 4 is hydrogen, straight chained, branched or cyclic C 1 -C 8 alkyl, or ##STR324## wherein R 5 is hydrogen, or straight chained or branched C 1 -C 4 alkyl, or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
47 words
The 3(2H)pyridazinone according to claim 4, wherein R 2 is hydrogen, and Y is hydrogen, chlorine, nitro, amino, or --OR 4 wherein R 4 is straight chained or branched C 1 -C 8 alkyl, C 3 -C 6 cycloalkyl, or benzyl, or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
55 words
The 3(2H)pyridazinone according to claim 5, wherein Ar is ##STR325## wherein each of Z 1 and Z 2 which may be the same or different, is hydrogen, chlorine, straight chained C 1 -C 4 alkyl, or --OR 6 wherein R 6 is straight chained C 1 -C 4 alkyl, or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
48 words
The 3(2H)pyridazinone according to claim 6, wherein Ar is ##STR326## wherein each of Z 1 and Z 2 which may be the same or different, is hydrogen, chlorine, or --OR 6 wherein R 6 is straight chained C 1 -C 4 alkyl, or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
32 words
An antagonistic agent against SRS-A comprising an effective amount of a 3(2H)pyridazinone of the formula I as defined in claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
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