US5011797A
Expired / Lapsed
US
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Composition and method for radiation synovectomy of arthritic joints
Assignee: University of Missouri–St. Louis
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Filing: 1989-09-15
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Granted: 1991-04-30
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Expires: 2009-09-15
Abstract
Abstract Radioactive microspheres for radiation synovectomy of arthritic joints in a mammal comprises a biodegradable glass material and a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout the glass material. The biodegradable glass material may be lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium aluminoborate, potassium germanate or potassium aluminogermanate and the beta radiation emitting radioisotope may be samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 or yttrium-90. Method for preparing such microspheres and for carrying out radiation synovectomy of arthritic joints utilizing such microspheres are also disclosed.
Inventors
- 👤 Delbert E. Day
- 👤 Gary J. Ehrhardt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 04:02
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1258; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1611; A61K2121/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
87 words
A nonradioactive microsphere adapted for radiation synovectomy on arthritic joints in a mammal comprising a biologically compatible glass material selected from the group consisting of magnesium aluminosilicate and aluminosilicate and containing an isotope selected from the group consisting of samarium, holmium, erbium, dysprosium, and rhenium chemically dissolved in and distributed substantially uniformly throughout said glass material and which, upon being subjected to an effective amount of neutron irradiation, will produce a beta emitting radioisotope selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186 and rhenium-188.
Claim 2
Dependent Claim
87 words
A nonradioactive microsphere adapted for radiation synovectomy on arthritic joints in a mammal comprising a biologically compatible glass material selected from the group consisting of magnesium aluminosilicate and aluminosilicate and containing an isotope selected from the group consisting of samarium, holmium, erbium, dysprosium, and rhenium chemically dissolved in and distributed substantially uniformly throughout said glass material and which, upon being subjected to an effective amount of neutron irradiation, will produce a beta emitting radioisotope selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186 and rhenium-188.
Claim 3
Dependent Claim
20 words
A microsphere as set forth in claim 1 wherein said glass material is magnesium aluminosilicate and said radioisotope is samarium-153.
Claim 4
Dependent Claim
19 words
A microsphere as set forth in claim 1 wherein said glass material is aluminosilicate and said radioisotope is samarium-153.
Claim 5
Dependent Claim
20 words
A microsphere as set forth in claim 1 wherein said glass material is magnesium aluminosilicate and said radioisotope is holmium-166.
Claim 6
Dependent Claim
19 words
A microsphere as set forth in claim 1 wherein said glass material is aluminosilicate and said radioisotope is holmium-166.
Claim 7
Dependent Claim
24 words
A microsphere as set forth in claim 1 wherein said microsphere has a diameter in the range of about 3 to about 30 micrometers.
Claim 8
Dependent Claim
45 words
A microsphere as set forth in claim 1 wherein the composition of said microsphere is approximately 20% by weight MgO, approximately 21% by weight Al 2 O 3 , approximately 52% by weight SiO 2 and approximately 7% by weight Sm 2 O 3 .
Claim 9
Dependent Claim
40 words
A microsphere as set forth in claim 1 wherein the composition of said microsphere is approximately 20% by weight Al 2 O 3 , approximately 40% by weight SiO 2 and approximately 40% by weight Sm 2 O 3 .
Claim 10
Dependent Claim
106 words
A nonradioactive microsphere adapted for radiation synovectomy of arthritic joints in a mammal comprising a biodegradable glass material selected from the group consisting of lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium aluminoborate, potassium germanate and potassium aluminogermanate and containing an isotope selected from the group consisting of samarium, holmium, erbium, dysprosium, rhenium and yttrium chemically dissolved in and distributed substantially uniformly throughout said glass material and which, upon being subjected to an effective amount of neutron irradiation, will produce a beta radiation emitting radioisotope selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 and yttrium-90.
Claim 11
Dependent Claim
106 words
A nonradioactive microsphere adapted for radiation synovectomy of arthritic joints in a mammal comprising a biodegradable glass material selected from the group consisting of lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium aluminoborate, potassium germanate and potassium aluminogermanate and containing an isotope selected from the group consisting of samarium, holmium, erbium, dysprosium, rhenium and yttrium chemically dissolved in and distributed substantially uniformly throughout said glass material and which, upon being subjected to an effective amount of neutron irradiation, will produce a beta radiation emitting radioisotope selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 and yttrium-90.
Claim 12
Dependent Claim
20 words
A microsphere as set forth in claim 9 wherein said glass material is lithium silicate and said radioisotope is samarium-153.
Claim 13
Dependent Claim
20 words
A microsphere as set forth in claim 9 wherein said glass material is lithium aluminosilicate and said radioisotope is samarium-153.
Claim 14
Dependent Claim
20 words
A microsphere as set forth in claim 9 wherein said glass material is lithium aluminoborate and said radioisotope is samarium-153.
Claim 15
Dependent Claim
20 words
A microsphere as set forth in claim 9 wherein said glass material is lithium silicate and said radioisotope is holmium-166.
Claim 16
Dependent Claim
20 words
A microsphere as set forth in claim 9 wherein said glass material is lithium aluminosilicate and said radioisotope is holmium-166.
Claim 17
Dependent Claim
20 words
A microsphere as set forth in claim 9 wherein said glass material is lithium aluminoborate and said radioisotope is holmium-166.
Claim 18
Dependent Claim
24 words
A microsphere as set forth in claim 9 wherein said microsphere has a diameter in the range of about 3 to about 30 micrometers.
Claim 19
Dependent Claim
38 words
A microsphere as set forth in claim 9 wherein the composition of said microsphere is approximately 20.1% by weight Li 2 O, approximately 74.9% by weight SiO 2 and apprOximately 5% by weight Sm 2 O 3 .
Claim 20
Dependent Claim
47 words
A microsphere as set forth in claim 9 wherein the composition of said microsphere is approximately 21.8% by weight Li 2 O, approximately 3.9% by weight Al 2 O 3 , approximately 69.3% by weight SiO 2 and approximately 5% by weight Sm 2 O 3 .
Claim 21
Dependent Claim
47 words
A microsphere as set forth in claim 9 wherein the composition of said microsphere is approximately 19.7% by weight Li 2 O, approximately 13.1% by weight B 2 O 3 , approximately 62.2% by weight SiO 2 and approximately 5% by weight Sm 2 O 3 .
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-04-29 | 1994-10-29 | 1995-04-30 | $2000.00 | Window Closed / Lapsed |
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