US5010204A
Expired / Lapsed
US
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Acetazolamide-related compounds, process for their preparation, and pharmaceutical composition containing the same
Assignee: Instituto Chimico Internazionale Dr Giuseppe Rende Srl
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Filing: 1989-07-18
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Granted: 1991-04-23
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Expires: 2009-07-18
Abstract
Abstract Compounds related to acetazolamide and to its N-methyl derivatives, of the formulae: ##STR1## wherein Y is one of the following groups: ##STR2## R 1 being a straight or branched alkylene or arylalkylene, or a phenylene, and the processes for their preparation; the compounds so obtained are inhibitors of carbonic anhydrase like acetazolamide but, in addition, they are well absorbed topically so that they can be used as drugs for treating glaucoma.
Inventors
- 👤 Simonetta Antonaroli
- 👤 Armandodariano Bianco
- 👤 Mario Brufani
- 👤 Giuseppe Lo Baido
- 👤 Giorgio Rende
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:42
CPC Classifications
C; C07; C07D; C07D285/00; C07D285/01; C07D285/02; C07D285/04; C07D285/12; C07D285/125; C07D285/135; A; A61; A61P; A61P27/00; A61P27/02; A61P27/06; A61P43/00; C07D417/00; C07D417/02; C07D417/12
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
76 words
Acetazolamide or its N-methyl derivatives, having inhibiting activity of carbonic anhydrase, of the formulae: ##STR22## wherein Y is: ##STR23## wherein R 1 is a straight or branched alkylene or arylalkylene, or a phenylene, R 2 is hydrogen or a straight or branched alkyl possibly substituted with halogen, R 3 and R 4 , which can be the same or different from each other, and hydrogen or straight or branched alkyl, and the physiologically acceptable salts thereof.
Claim 2
Dependent Claim
76 words
Acetazolamide or its N-methyl derivatives, having inhibiting activity of carbonic anhydrase, of the formulae: ##STR22## wherein Y is: ##STR23## wherein R 1 is a straight or branched alkylene or arylalkylene, or a phenylene, R 2 is hydrogen or a straight or branched alkyl possibly substituted with halogen, R 3 and R 4 , which can be the same or different from each other, and hydrogen or straight or branched alkyl, and the physiologically acceptable salts thereof.
Claim 3
Dependent Claim
48 words
The compounds according to claim 1, wherein Y is the group: ##STR24## wherein R 3 and R 4 , which can be the same or different from each other, are hydrogen or a lower alkyl of 1-6 carbon atoms and n is an integer between 1 and 10.
Claim 4
Dependent Claim
80 words
N-methyl derivatives of acetazolamide, having inhibiting activity of carbonic anhydrase, of the formulae: ##STR25## wherein Y is one of the following groups: ##STR26## wherein R 1 is a straight or branched alkylene or arylalkylene, or a phenylene, R 2 is hydrogen or a straight or branched alkyl possibly substituted with halogen, R 3 and R 4 , which can be the same or different from each other, are hydrogen or straight or branched alkyl, and the physiologically acceptable salts thereof.
Claim 5
Dependent Claim
80 words
N-methyl derivatives of acetazolamide, having inhibiting activity of carbonic anhydrase, of the formulae: ##STR25## wherein Y is one of the following groups: ##STR26## wherein R 1 is a straight or branched alkylene or arylalkylene, or a phenylene, R 2 is hydrogen or a straight or branched alkyl possibly substituted with halogen, R 3 and R 4 , which can be the same or different from each other, are hydrogen or straight or branched alkyl, and the physiologically acceptable salts thereof.
Claim 6
Dependent Claim
43 words
The compounds according to claim 3, wherein Y is the group: R.sub.2 OCO--(CH.sub.2).sub.n -- wherein R 2 is hydrogen or a straight or branched alkyl having 1-20 carbon atoms and possibly substituted with halogen, and n is an integer between 1 and 10.
Claim 7
Dependent Claim
27 words
The compounds according to claim 3, wherein Y is the group: ##STR27## wherein R 2 is hydrogen or a straight or branched alkyl having 1-20 carbon atoms.
Claim 8
Dependent Claim
51 words
The compounds according to claim 3, wherein Y is the group of the formula: ##STR28## wherein R 3 and R 4 , which can be the same or different from each other, are hydrogen or a lower alkyl of 1-6 carbon atoms, and n is an integer between 1 and 10.
Claim 9
Dependent Claim
48 words
The compounds according to claim 3, wherein Y is the group: ##STR29## wherein R 3 and R 4 , which can be the same or different from each other, are hydrogen or a lower alkyl of 1-6 carbon atoms and n is an integer between 1 and 10.
References Cited (Backward Citations)
US4151167A
Cited
US4483864A
Cited
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