Abstract Film coated pharmaceutical preparations, which are prepared by overlaying to the outer surface of pharmaceutical preparations, a coating layer comprising at least one member selected from the group consisting of methyl cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, carboxymethylethyl cellulose and cellulose acetate phthalate, are irradiated with light including ultraviolet rays. Whereby film coated pharmaceutical preparations, the coating layer surface of which are excellent in whiteness, are prepared. Moreover, as a content of a white pigment in corporated into the coating layer of such preparations may be reduced, the stability of such preparations can be enhanced without impairing the strength of the coating layer.
A method for providing white colored film coated pharmaceutical preparations, said method comprising the steps of providing pharmaceutical preparations having a film coating material containing moisture, and irradiating said film coating with ultra violet rays to partially oxidize the material to a Yellowness Index in the range of about 5.1 to 9.8, wherein said film coating material comprises at least one member selected from the group consisting of methyl cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, carboxymethyl cellulose and cellulose acetate phthalate.
Claim 2
Independent Claim
87 words
A method for providing white colored film coated pharmaceutical preparations, said method comprising the steps of providing pharmaceutical preparations having a film coating material containing moisture, and irradiating said film coating with ultra violet rays to partially oxidize the material to a Yellowness Index in the range of about 5.1 to 9.8, wherein said film coating material comprises at least one member selected from the group consisting of methyl cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, carboxymethyl cellulose and cellulose acetate phthalate.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein said ultraviolet rays have a wavelength in the range of 200 nm to 380 nm.
Claim 4
Dependent Claim
14 words
The method of claim 1 wherein said mositure content is at least 0.3 percent.
Claim 5
Dependent Claim
14 words
The method of claim 1 wherein said moisture content is at least 1.3 percent.
Claim 6
Independent Claim
10 words
The method of claim additionally comprising drying during the irradiating.