US5005574A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Temperature-based, rate-modulated cardiac therapy apparatus and method
Assignee: Cook Research Inc
•
Filing: 1989-11-28
•
Granted: 1991-04-09
•
Expires: 2009-11-28
Abstract
Abstract A temperature-based, rate-modulated cardiac pacemaker having means for variably controlling the stimulation rate of the heart according to multiple temperature characteristics of the blood referenced to multiple moving baseline temperatures. A target rate is periodically calculated by obtaining a weighted sum of the following rate components: (1) the magnitude of a decrease in temperature below resting temperature, a first moving baseline, (2) the magnitude of an increase in temperature above a local minimum temperature, a second moving baseline, (3) the magnitude of an increase in the resting baseline above a daily minimum temperature, a third moving baseline, and (4) the absolute value of the rate of change of temperature. The resting temperature is preferably calculated over a longer interval than the local minimum temperature but a much shorter interval than the daily minimum temperature. A positive rate of change of temperature is distinguished from a negative rate of change of temperature and is used differently in the calculation of target rate. The target rate is not directly applied as the new pacing rate but is instead averaged with the previous rate in order to provide smoother transitions between pacing rates. An intermediate rate limit is included in addition to lower and upper rate limits, and rank filtering is employed in the determination of rate components.
Inventors
- 👤 Neal E. Fearnot
- 👤 Merry L. Evans
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 00:01
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/362; A61N1/365; A61N1/36514; A61N1/3655
Claims Analysis
Total Claims: 83
Claim 1
Independent Claim
78 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing central venous blood temperature; and processing means coupled to said sensing means for calculating cardiac rate as a function of temperature conditions, one of said conditions including a dip in central venous blood temperature at the onset of exercise, said processing means including means for calculating a first rate component proportional to the magnitude of said dip; and means for increasing cardiac rate by said first rate component.
Claim 2
Dependent Claim
78 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing central venous blood temperature; and processing means coupled to said sensing means for calculating cardiac rate as a function of temperature conditions, one of said conditions including a dip in central venous blood temperature at the onset of exercise, said processing means including means for calculating a first rate component proportional to the magnitude of said dip; and means for increasing cardiac rate by said first rate component.
Claim 3
Dependent Claim
50 words
The cardiac therapy device of claim 1 wherein said processing means further includes means for calculating a second rate component proportional to the absolute value of the rate of change of temperature; and means for increasing cardiac rate by said second rate component in addition to said first rate component.
Claim 4
Dependent Claim
48 words
The cardiac therapy device of claim 2 wherein said second rate component calculating means includes means for calculating said second rate component with one scale factor for a negative rate of change of temperature and with a greater scale factor for a positive rate of change of temperature.
Claim 5
Dependent Claim
58 words
The cardiac therapy device of claim 3 wherein said processing means further includes means for deriving a local minimum temperature; means for calculating a third rate component proportional to an increase in temperature above said local minimum temperature; and means for increasing cardiac rate by said third rate component in addition to said first and second rate components.
Claim 6
Dependent Claim
67 words
The cardiac therapy device of claim 4 wherein said processing means further includes means for deriving a resting temperature; means for deriving a daily minimum temperature; means for calculating a fourth rate component proportional to an increase in said resting temperature above said daily minimum temperature; and means for increasing cardiac rate by said fourth rate component in addition to said first, second and third rate components.
Claim 7
Dependent Claim
71 words
The cardiac therapy device of claim 5 wherein said first rate component is proportional to said resting temperature minus current temperature; said third rate component is proportional to current temperature minus said local minimum temperature; said fourth rate component is proportional to said resting temperature minus said daily minimum temperature; and wherein said processing means includes means for inhibiting response to negative values of said first, third and fourth rate components.
Claim 8
Dependent Claim
49 words
The cardiac therapy device of claim 6 further comprising smoothing means for limiting the rate of change of cardiac rate, said smoothing means including means for limiting the change in cardiac rate during a predetermined interval to a fraction of the cardiac rate change calculated by said processing means.
Claim 9
Dependent Claim
23 words
The cardiac therapy device of claim 7 further comprising rate limit means for limiting the cardiac rate increase in stages during calculation thereof.
Claim 10
Dependent Claim
56 words
The cardiac therapy device of claim 1 wherein said processing means further includes means for deriving a local minimum temperature; means for calculating a second rate component proportional to an increase in temperature above said local minimum temperature; and means for increasing cardiac rate by said second rate component in addition to said first rate component.
Claim 11
Dependent Claim
64 words
The cardiac therapy device of claim 1 wherein said processing means further includes means for deriving a resting temperature; means for deriving a daily minimum temperature; means for calculating a second rate component proportional to an increase in said resting temperature above said daily minimum temperature; and means for increasing cardiac rate by said second rate component in addition to said first rate component.
Claim 12
Dependent Claim
47 words
The cardiac therapy device of claim 1 wherein said processing means further includes means for deriving a resting temperature; and means for inhibiting response to a negative value of said first rate component; wherein said first rate component is proportional to said resting temperature minus current temperature.
Claim 13
Dependent Claim
45 words
The cardiac therapy device of claim 1 further comprising smoothing means for limiting the rate of change of cardiac rate, said smoothing means including means for limiting the change in cardiac rate to a fraction of the cardiac rate change calculated by said processing means.
Claim 14
Dependent Claim
46 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing blood temperature; and processing means coupled to said sensing means for calculating cardiac rate, said processing means including means for increasing cardiac rate by an amount proportional to the magnitude of a dip in blood temperature.
Claim 15
Dependent Claim
46 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing blood temperature; and processing means coupled to said sensing means for calculating cardiac rate, said processing means including means for increasing cardiac rate by an amount proportional to the magnitude of a dip in blood temperature.
Claim 16
Dependent Claim
33 words
The cardiac therapy device of claim 13 wherein said processing means further includes means for increasing cardiac rate by an amount proportional to the absolute value of the rate of change of temperature.
Claim 17
Dependent Claim
46 words
The cardiac therapy device of claim 14 wherein said processing means further includes means for calculating a cardiac rate increase with one scale factor for a negative rate of change of temperature and with a greater scale factor for a positive rate of change of temperature.
Claim 18
Dependent Claim
40 words
The cardiac therapy device of claim 15 wherein said processing means further includes means for deriving a local minimum temperature; and means for increasing cardiac rate by an amount proportional to an increase in temperature above said local minimum temperature.
Claim 19
Dependent Claim
48 words
The cardiac therapy device of claim 16 wherein said processing means further includes means for deriving a resting temperature; means for deriving a daily minimum temperature; and means for increasing cardiac rate by an amount proportional to an increase in said resting temperature above said daily minimum temperature.
Claim 20
Dependent Claim
40 words
The cardiac therapy device of claim 13 wherein said processing means further includes means for deriving a local minimum temperature; and means for increasing cardiac rate by an amount proportional to an increase in temperature above said local minimum temperature.
Claim 21
Dependent Claim
47 words
The cardiac therapy device of claim 13 wherein said processing means further includes means for deriving a resting temperature; means for deriving a daily minimum temperature; means for increasing cardiac rate by an amount proportional to an increase in said resting temperature above said daily minimum temperature.
Claim 22
Dependent Claim
30 words
The cardiac therapy device of claim 13 wherein said processing means further includes means for increasing cardiac rate by an amount proportional to a positive rate of change of temperature.
Claim 23
Dependent Claim
34 words
The cardiac therapy device of claim 20 wherein said processing means further includes means for increasing cardiac rate by an amount proportional to the additive inverse of a negative rate of change of temperature.
Claim 24
Dependent Claim
40 words
The cardiac therapy device of claim 21 wherein said processing means further includes means for deriving a local minimum temperature; and means for increasing cardiac rate by an amount proportional to an increase in temperature above said local minimum temperature.
Claim 25
Dependent Claim
48 words
The cardiac therapy device of claim 22 wherein said processing means further includes means for deriving a resting temperature; means for deriving a daily minimum temperature; and means for increasing cardiac rate by an amount proportional to an increase in said resting temperature above said daily minimum temperature.
Claim 26
Dependent Claim
112 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing blood temperature; means coupled to said sensing means for determining first, second and third moving baseline temperatures; and processing means coupled to said sensing means for calculating cardiac rate, said processing means including summing means for obtaining a weighted sum of a plurality of the following rate components: the magnitude of a decrease in temperature below said first moving baseline temperature; the magnitude of an increase in temperature above said second moving baseline temperature; the magnitude of an increase in said first moving baseline temperature above said third moving baseline temperature; and the absolute value of the rate of change of temperature.
Claim 27
Dependent Claim
112 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing blood temperature; means coupled to said sensing means for determining first, second and third moving baseline temperatures; and processing means coupled to said sensing means for calculating cardiac rate, said processing means including summing means for obtaining a weighted sum of a plurality of the following rate components: the magnitude of a decrease in temperature below said first moving baseline temperature; the magnitude of an increase in temperature above said second moving baseline temperature; the magnitude of an increase in said first moving baseline temperature above said third moving baseline temperature; and the absolute value of the rate of change of temperature.
Claim 28
Dependent Claim
53 words
The cardiac therapy device of claim 24 wherein said determining means includes means for calculating said first, second and third moving baseline temperatures periodically from temperature measurements taken over first, second and third intervals, respectively, said first interval exceeding said second interval in length, said third interval exceeding said first interval in length.
Claim 29
Dependent Claim
28 words
The cardiac therapy device of claim 25 wherein said determining means includes rank filter means for ranking multiple temperature values and selecting a value of predetermined rank therefrom.
Claim 30
Dependent Claim
56 words
The cardiac therapy device of claim 26 further comprising smoothing means for limiting the rate of change of cardiac rate, said smoothing means including means for limiting a change in cardiac rate during a predetermined interval to a fraction of the difference between current cardiac rate and a new cardiac rate calculated by said processing means.
Claim 31
Dependent Claim
32 words
The cardiac therapy device of claim 27 further comprising means for determining a lower rate limit, wherein said summing means includes means for adding said weighted sum to said lower rate limit.
Claim 32
Dependent Claim
92 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing venous blood temperature; and processing means coupled to said sensing means for calculating cardiac rate, said processing means including means for distinguishing between positive and negative rates of change of temperature; means for calculating a first rate component proportional to the magnitude of a negative rate of change of temperature; means for calculating a second rate component proportional to the magnitude of a positive rate of change of temperature; and means for increasing cardiac rate by said first and second rate components.
Claim 33
Dependent Claim
92 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing venous blood temperature; and processing means coupled to said sensing means for calculating cardiac rate, said processing means including means for distinguishing between positive and negative rates of change of temperature; means for calculating a first rate component proportional to the magnitude of a negative rate of change of temperature; means for calculating a second rate component proportional to the magnitude of a positive rate of change of temperature; and means for increasing cardiac rate by said first and second rate components.
Claim 34
Dependent Claim
38 words
The cardiac therapy device of claim 29 further comprising means for storing first and second scale factors for said first and second rate component calculating means, respectively, said second scale factor being greater than said first scale factor.
Claim 35
Dependent Claim
46 words
The cardiac therapy device of claim 29 wherein said processing means further includes means for periodically executing a cardiac rate calculation; and wherein said means for increasing cardiac rate is responsive to only one of said first and second rate components during each cardiac rate calculation.
Claim 36
Dependent Claim
110 words
The cardiac therapy device of claim 31 wherein said means for increasing cardiac rate includes means for alternatively adding said first and second rate components to a subtotal of other rate components; further comprising rate limit means for limiting the effect of said first and second rate components, said rate limit means including means responsive to a negative rate of change of temperature for limiting the sum of said subtotal and said first rate component to a predetermined intermediate rate limit value; and means responsive to a positive rate of change of temperature for limiting said subtotal to said intermediate rate limit value before said second rate component is added.
Claim 37
Dependent Claim
110 words
The cardiac therapy device of claim 29 wherein said means for increasing cardiac rate includes means for alternatively adding said first and second rate components to a subtotal of other rate components; further comprising rate limit means for limiting the effect of said first and second rate components, said rate limit means including means responsive to a negative rate of change of temperature for limiting the sum of said subtotal and said first rate component to a predetermined intermediate rate limit value; and means responsive to a positive rate of change of temperature for limiting said subtotal to said intermediate rate limit value before said second rate component is added.
Claim 38
Dependent Claim
112 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing venous blood temperature, said sensing means including means for producing a plurality of temperature values per minute; and processing means coupled to said sensing means for calculating cardiac rate in response to diurnal variations and deviations from resting temperature, said processing means including means for deriving a daily minimum temperature from temperature values produced over a 24-hour period; means for detecting temperature deviations from said daily minimum temperature; means for deriving a resting temperature from temperature values produced over an interval less than approximately 12 hours; means for detecting temperature deviations from said resting temperature; and means for combining said temperature deviations.
Claim 39
Dependent Claim
112 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing venous blood temperature, said sensing means including means for producing a plurality of temperature values per minute; and processing means coupled to said sensing means for calculating cardiac rate in response to diurnal variations and deviations from resting temperature, said processing means including means for deriving a daily minimum temperature from temperature values produced over a 24-hour period; means for detecting temperature deviations from said daily minimum temperature; means for deriving a resting temperature from temperature values produced over an interval less than approximately 12 hours; means for detecting temperature deviations from said resting temperature; and means for combining said temperature deviations.
Claim 40
Dependent Claim
54 words
The cardiac therapy device of claim 34 wherein said means for detecting temperature deviations from said daily minimum temperature includes means for detecting the magnitude of an increase in said resting temperature above said daily minimum temperature, and means for inhibiting response to a decrease in said resting temperature below said daily minimum temperature.
Claim 41
Dependent Claim
102 words
The cardiac therapy device of claim 35 further comprising: means for deriving a local minimum temperature from temperature values produced over an interval less than the interval for said resting temperature; and means for detecting the magnitude of an increase in temperature above said local minimum temperature, and means for inhibiting response to a decrease in temperature below said local minimum temperature; wherein said means for detecting temperature deviations from said resting temperature includes means for detecting the magnitude of a decrease in temperature below said resting temperature, and means for inhibiting response to an increase in temperature above said resting temperature.
Claim 42
Dependent Claim
36 words
The cardiac therapy device of claim 36 wherein said means for deriving a resting temperature includes means for deriving a resting temperature from temperature values produced over an interval of between approximately 8 and 40 minutes.
Claim 43
Dependent Claim
26 words
The cardiac therapy device of claim 37 wherein said means for deriving a daily minimum temperature includes means for comparing different values of said resting temperature.
Claim 44
Dependent Claim
45 words
A temperature-based method of modulating cardiac rate, comprising the steps: sensing blood temperature; and calculating a new cardiac rate in response to sensed blood temperature, said calculating step including increasing cardiac rate by an amount proportional to the magnitude of a dip in blood temperature.
Claim 45
Dependent Claim
45 words
A temperature-based method of modulating cardiac rate, comprising the steps: sensing blood temperature; and calculating a new cardiac rate in response to sensed blood temperature, said calculating step including increasing cardiac rate by an amount proportional to the magnitude of a dip in blood temperature.
Claim 46
Dependent Claim
26 words
The method of claim 39 wherein said calculating step further includes increasing cardiac rate by an amount proportional to a positive rate of change of temperature.
Claim 47
Dependent Claim
30 words
The method of claim 40 wherein said calculating step further includes increasing cardiac rate by an amount proportional to the additive inverse of a negative rate of change of temperature.
Claim 48
Dependent Claim
34 words
The method of claim 41 wherein said calculating step further includes deriving a local minimum temperature; and increasing cardiac rate by an amount proportional to an increase in temperature above said local minimum temperature.
Claim 49
Dependent Claim
40 words
The method of claim 42 wherein said calculating step further includes deriving a resting temperature; deriving a daily minimum temperature; and increasing cardiac rate by an amount proportional to an increase in said resting temperature above said daily minimum temperature.
Claim 50
Dependent Claim
34 words
The method of claim 39 wherein said calculating step further includes deriving a local minimum temperature; and increasing cardiac rate by an amount proportional to an increase in temperature above said local minimum temperature.
Claim 51
Dependent Claim
40 words
The method of claim 39 wherein said calculating step further includes deriving a resting temperature; deriving a daily minimum temperature; and increasing cardiac rate by an amount proportional to an increase in said resting temperature above said daily minimum temperature.
Claim 52
Dependent Claim
103 words
A temperature-based method of modulating cardiac rate, comprising the steps: sensing blood temperature; determining first, second and third moving baseline temperatures; and calculating a new cardiac rate in response to sensed blood temperature, said calculating step including obtaining a weighted sum of a plurality of the following rate components: the magnitude of a decrease in temperature below said first moving baseline temperature; the magnitude of an increase in temperature above said second moving baseline temperature; the magnitude of an increase in said first moving baseline temperature above said third moving baseline temperature; and the absolute value of the rate of change of temperature.
Claim 53
Dependent Claim
103 words
A temperature-based method of modulating cardiac rate, comprising the steps: sensing blood temperature; determining first, second and third moving baseline temperatures; and calculating a new cardiac rate in response to sensed blood temperature, said calculating step including obtaining a weighted sum of a plurality of the following rate components: the magnitude of a decrease in temperature below said first moving baseline temperature; the magnitude of an increase in temperature above said second moving baseline temperature; the magnitude of an increase in said first moving baseline temperature above said third moving baseline temperature; and the absolute value of the rate of change of temperature.
Claim 54
Dependent Claim
49 words
The method of claim 46 wherein said determining step includes calculating said first, second and third moving baseline temperatures periodically from temperature measurements taken over first, second and third intervals, respectively, said first interval exceeding said second interval in length, said third interval exceeding said first interval in length.
Claim 55
Dependent Claim
22 words
The method of claim 47 wherein said determining step includes ranking multiple temperature values and selecting a value of predetermined rank therefrom.
Claim 56
Dependent Claim
52 words
The method of claim 48 further comprising the step of limiting the rate of change of cardiac rate, said limiting step including limiting a change in cardiac rate during a predetermined interval to a fraction of the difference between current cardiac rate and a new cardiac rate calculated in said calculating step.
Claim 57
Dependent Claim
29 words
The method of claim 49 further comprising the step of determining a lower rate limit, wherein said calculating step includes adding said weighted sum to said lower rate limit.
Claim 58
Dependent Claim
130 words
A temperature-based, rate-modulated cardiac therapy device, comprising: sensing means for sensing central venous blood temperature; sampling means coupled to said sensing means for periodically creating indicia of central venous blood temperature; at least one buffer means for storing a plurality of said indicia of central venous blood temperature; processing means coupled to said at least one buffer means for determining a cardiac pacing rate including a first rate component which is a function of the dip in central venous blood temperature which occurs at the onset of exercise, said processing means including means for calculating said first rate component such that it is proportional to the magnitude of said dip in central venous blood temperature; and means for increasing the cardiac pacing rate by said at least one rate component.
Claim 59
Dependent Claim
130 words
A temperature-based, rate-modulated cardiac therapy device, comprising: sensing means for sensing central venous blood temperature; sampling means coupled to said sensing means for periodically creating indicia of central venous blood temperature; at least one buffer means for storing a plurality of said indicia of central venous blood temperature; processing means coupled to said at least one buffer means for determining a cardiac pacing rate including a first rate component which is a function of the dip in central venous blood temperature which occurs at the onset of exercise, said processing means including means for calculating said first rate component such that it is proportional to the magnitude of said dip in central venous blood temperature; and means for increasing the cardiac pacing rate by said at least one rate component.
Claim 60
Dependent Claim
125 words
The cardiac therapy device of claim 51, wherein said at least one buffer means stores a first predetermined number of indicia of central venous blood temperature during a first time period of a first predetermined duration, and a second predetermined number of indicia of central venous blood temperature during a second time period of a second predetermined duration, said first time period immediately preceding in time said second time period, said processing means including means for determining, based on the indicia stored in said first and said second time periods, a second rate component which is proportional to the absolute value of the rate of change of central venous blood temperature; and means for increasing cardiac rate by both of said first second rate components.
Claim 61
Dependent Claim
45 words
The cardiac therapy device of claim 52, wherein said second rate component which is proportional to the absolute value of the rate of change of central venous blood temperature is proportionally greater for a positive rate of change than for a negative rate of change.
Claim 62
Dependent Claim
171 words
The cardiac therapy device of claim 52, having a second buffer means, said second buffer means storing a plurality of said indicia of central venous blood temperature, said indicia being selected for storage in said second buffer means from said second predetermined number of indicia at a first periodic interval which is representative of a predetermined minimum value of said second predetermined number of indicia stored in said at least one buffer at the time said indicia is selected, one of said indicia stored in said second buffer being selected to represent a local minimum central venous blood temperature, said processing means including means for determining, based on said indicia representing a local minimum central venous blood temperature and on the indicia most recently selected for storage in said second buffer, a third rate component which is proportional to an increase in temperature above ,said local minimum central venous blood temperature, and means for increasing cardiac rate by said third rate component in addition to said first and second rate components.
Claim 63
Dependent Claim
62 words
The cardiac therapy device of claim 54, wherein said indicia selected for storage in said second buffer means from said second predetermined number of indicia, is the indicia representative of the second lowest central venous blood temperature, and said indicia stored in said second buffer selected to represent a local minimum temperature is the indicia representing the lowest central venous blood temperature.
Claim 64
Dependent Claim
50 words
The cardiac therapy device of claim 54, wherein said sampling means creates an indicia of central venous blood temperature at approximately ten second intervals, said first and second time periods are each of approximately one minute duration, and said first periodic interval is of from one to five minutes duration.
Claim 65
Dependent Claim
22 words
The cardiac therapy device of claim 56, wherein said second buffer means stores six of said indicia of central venous blood temperature.
Claim 66
Dependent Claim
229 words
The cardiac therapy device of claim 54, having a third buffer means and a fourth buffer means, said third buffer means storing a plurality of indicia representative of the average value of the indicia stored in said first buffer means during said second time period at a second periodic interval which is greater in duration than said first time period, one of said indicia stored in said third buffer means being selected to represent a resting central venous blood temperature, said fourth buffer means storing an indicia representative of the daily minimum central venous blood temperature, said indicia selected for storage in said fourth buffer being the indicia representing the lowest resting central venous temperature occurring during a third periodic interval of approximately twenty-four hours duration, the indicia stored in said fourth buffer at the end of said third period being used to represent the daily minimum central venous blood temperature for the next twenty-four hour period, said processing means including means for determining, based on said indicia representing the daily minimum central venous blood temperature and on said indicia representing the resting central venous blood temperature, a fourth rate component which is proportional to an increase in resting temperature above, said daily minimum central venous blood temperature, and means for increasing cardiac rate by said fourth rate component in addition to said first, second, and third rate components.
Claim 67
Dependent Claim
92 words
The cardiac therapy device of claim 58, wherein said first rate component is proportional to said resting central venous blood temperature minus said current central venous blood temperature, said third rate component is proportional to said current central venous blood temperature minus said local minimum central venous blood temperature, said fourth rate component is proportional to said resting central venous blood temperature minus said daily minimum central venous blood temperature, and said processing means includes means for inhibiting response to negative values of said first, said third, and said fourth rate components.
Claim 68
Dependent Claim
61 words
The cardiac therapy device of claim 59, wherein said processing means includes smoothing means for limiting the rate of change of cardiac rate, said smoothing means including means for limiting the change in cardiac rate during a fourth periodic interval to a portion of the cardiac rate change represented by the total of said first, second, third and fourth rate components.
Claim 69
Dependent Claim
35 words
The cardiac therapy device of claim 60, wherein said processing means includes rate limiting means, which limits the cardiac pacing rate to rates between a lower base pacing rate and an upper maximum pacing rate.
Claim 70
Dependent Claim
61 words
The cardiac therapy device of claim 58, wherein said processing means includes smoothing means for limiting the rate of change of cardiac rate, said smoothing means including means for limiting the change in cardiac rate during a fourth periodic interval to a portion of the cardiac rate change represented by the total of said first, second, third and fourth rate components.
Claim 71
Dependent Claim
35 words
The cardiac therapy device of claim 62, wherein said processing means includes rate limiting means, which limits the cardiac pacing rate to rates between a lower base pacing rate and an upper maximum pacing rate.
Claim 72
Dependent Claim
62 words
The cardiac therapy device of claim 58, wherein said processing means includes intermediate rate limiting means which limits the increase in cardiac rate due to said first, second, and fourth rate components to an intermediate rate for negative rates of change of central venous blood temperature, such that said cardiac rate is limited to said intermediate rate plus said third rate component.
Claim 73
Dependent Claim
61 words
The cardiac therapy device of claim 64, wherein said processing means includes smoothing means for limiting the rate of change of cardiac rate, said smoothing means including means for limiting the change in cardiac rate during a fourth periodic interval to a portion of the cardiac rate change represented by the total of said first, second, third and fourth rate components.
Claim 74
Dependent Claim
35 words
The cardiac therapy device of claim 65, wherein said processing means includes rate limiting means, which limits the cardiac pacing rate to rates between a lower base pacing rate and an upper maximum pacing rate.
Claim 75
Dependent Claim
63 words
The cardiac therapy device of claim 58, wherein said processing means includes intermediate rate limiting means which limits the increase in cardiac rate due to said first and fourth rate components to an intermediate rate for positive rates of change of central venous blood temperature, such that said cardiac rate is limited to said intermediate rate plus said second and third rate components.
Claim 76
Dependent Claim
61 words
The cardiac therapy device of claim 67, wherein said processing means includes smoothing means for limiting the rate of change of cardiac rate, said smoothing means including means for limiting the change in cardiac rate during a fourth periodic interval to a portion of the cardiac rate change represented by the total of said first, second, third and fourth rate components.
Claim 77
Dependent Claim
35 words
The cardiac therapy device of claim 68, wherein said processing means includes rate limiting means, which limits the cardiac pacing rate to rates between a lower base pacing rate and an upper maximum pacing rate.
Claim 78
Dependent Claim
37 words
The cardiac therapy device of claim 52, wherein said sampling means creates indicia of central venous blood temperature at approximately ten second intervals, and said first and second time periods are each of approximately one minute duration.
Claim 79
Dependent Claim
99 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing venous blood temperature, said sensing means including means for producing a plurality of temperature values per minute; and processing means coupled to said sensing means for calculating cardiac rate in response to deviations between diurnal and resting temperatures, said processing means including means for deriving a daily minimum temperature from temperature values produced over a 24-hour period; means for deriving a resting temperature from temperature values produced over an interval less than approximately 12 hours; and means for deriving deviations between said daily minimum temperature and said resting temperature.
Claim 80
Dependent Claim
99 words
A temperature-based, rate-modulated cardiac therapy device, comprising: means for sensing venous blood temperature, said sensing means including means for producing a plurality of temperature values per minute; and processing means coupled to said sensing means for calculating cardiac rate in response to deviations between diurnal and resting temperatures, said processing means including means for deriving a daily minimum temperature from temperature values produced over a 24-hour period; means for deriving a resting temperature from temperature values produced over an interval less than approximately 12 hours; and means for deriving deviations between said daily minimum temperature and said resting temperature.
Claim 81
Dependent Claim
93 words
A temperature-based, rate-modulated cardiac therapy device, comprising: first sensing means for sensing a physiological state, said first sensing means including second sensing means for sensing venous blood temperature; sampling means coupled to said first sensing means for periodically creating indicia of said blood temperature; at least one buffer means for storing a plurality of said indicia of said blood temperature; processing means coupled to said at least one buffer means for determining a cardiac therapy including a first rate component which is proportional to the magnitude of a dip in said blood temperature.
Claim 82
Dependent Claim
93 words
A temperature-based, rate-modulated cardiac therapy device, comprising: first sensing means for sensing a physiological state, said first sensing means including second sensing means for sensing venous blood temperature; sampling means coupled to said first sensing means for periodically creating indicia of said blood temperature; at least one buffer means for storing a plurality of said indicia of said blood temperature; processing means coupled to said at least one buffer means for determining a cardiac therapy including a first rate component which is proportional to the magnitude of a dip in said blood temperature.
Claim 83
Dependent Claim
67 words
The device of claim 72 wherein said processing means include means for deriving a second rate component which is a function of at least one of a plurality of factors including a daily minimum temperature, a resting temperature, a rate of change of temperature, an absolute value of said rate of change of temperature, a local minimum temperature, and a weighted sum of a number of factors.
References Cited (Backward Citations)
US3867950A
Cited
DE2609365A1
Cited
US4436092A
Cited
US4543954A
Cited
US4436092B1
Cited
US4719920A
Cited
US4719920B1
Cited
US4803987A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-08 | 1994-10-08 | 1995-04-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-08 | 1998-10-08 | 1999-04-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-08 | 2002-10-08 | 2003-04-09 | $7700.00 | Window Closed / Lapsed |