US5004810A
Expired / Lapsed
US
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Antiviral oligomers
Assignee: Merck Sharp & Dohme LLC
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Filing: 1988-09-30
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Granted: 1991-04-02
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Expires: 2008-09-30
Abstract
Abstract Oligomers that are complementary in base sequence to the initiation region on mRNA coding for herpes simplex virus transactivating proteins inhibit the replication of the virus.
Inventors
- 👤 Kenneth G. Draper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 18:48
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; C; C07; C07H; C07H21/00; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/113; C12N15/1131; C12N15/1133
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
65 words
An oligomer capable of hybridizing to the second translation initiation region downstream from the 5' end of messenger RNA coding for a herpes simplex virus Vmw65 transactivating protein and substantially inhibiting translation of such messenger RNA, which oligomer comprises bases substantially complementary to such translation initiation region linked by a backbone comprising ribose phosphate, deoxyribose phosphate, ribose alkylphosphonate, deoxyribose alkylphosphonate, ribose arylphosphonate or deoxyribose arylphosphonate.
Claim 2
Dependent Claim
65 words
An oligomer capable of hybridizing to the second translation initiation region downstream from the 5' end of messenger RNA coding for a herpes simplex virus Vmw65 transactivating protein and substantially inhibiting translation of such messenger RNA, which oligomer comprises bases substantially complementary to such translation initiation region linked by a backbone comprising ribose phosphate, deoxyribose phosphate, ribose alkylphosphonate, deoxyribose alkylphosphonate, ribose arylphosphonate or deoxyribose arylphosphonate.
Claim 3
Dependent Claim
15 words
The oligomer of claim 1 in which the backbone comprises deoxyribose phosphate or deoxyribose alkylphosphonate.
Claim 4
Dependent Claim
22 words
The oligomer of claim 1 which is an oligodeoxynucleotide having the sequence, from 5' to 3': GTC CGC GTC CAT GTC GGC.
References Cited (Backward Citations)
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