US5004548A
Expired / Lapsed
US
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Method and apparatus for rinsing and priming an exchanger
Assignee: Gambro Industries SAS
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Filing: 1988-12-09
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Granted: 1991-04-02
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Expires: 2008-12-09
Abstract
Abstract A method and apparatus for rinsing and priming an exchanger divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid comprising the steps of circulating a sterile solution through the second compartment and depositing a protein film on at least one side of the membrane. The apparatus includes means for circulating a sterile solution through the second compartment, and means for depositing a protein film on at least one side of the membrane.
Inventors
- 👤 Gerard Richalley
- 👤 Jacques Burtin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:15
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3643; A61M1/3644; B01D65/00; B01D65/02; B01D2321/00; B01D2321/16; B01D2321/168
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
93 words
A method for rinsing and priming an exchanger divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising the steps of: (a) circulating a sterile solution through the first compartment to rinse the same; (b) circulating a sterile solution through the second compartment to rinse the same; and (c) depositing a protein film on at least one side of the semi-permeable membrane by circulating a sterile albumin solution through the first compartment.
Claim 2
Independent Claim
93 words
A method for rinsing and priming an exchanger divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising the steps of: (a) circulating a sterile solution through the first compartment to rinse the same; (b) circulating a sterile solution through the second compartment to rinse the same; and (c) depositing a protein film on at least one side of the semi-permeable membrane by circulating a sterile albumin solution through the first compartment.
Claim 3
Dependent Claim
36 words
The method of claim 1 wherein the step of depositing protein film includes circulating a sterile albumin solution through both the first and second compartments to deposit a protein film on both sides of the membrane.
Claim 4
Dependent Claim
49 words
The method of claim 1, wherein step (c) includes the sub-step of: (a) circulating blood to be treated through the first compartment, after rinsing the first compartment with the sterile solution, to deposit the protein film on the membrane, while maintaining the sterile rinsing solution in the second compartment.
Claim 5
Dependent Claim
59 words
The method of claim 1, wherein sterile solution is concurrently circulated through the first and second compartments and wherein step c includes the sub-step of circulating blood to be treated through the first compartment to deposit a protein film on the membrane while maintaining the sterile rinsing solution in the second compartment after rinsing the first and second compartments.
Claim 6
Dependent Claim
21 words
The method of claim 1, wherein the sterile solutions are circulated through the first and second compartments in the same direction.
Claim 7
Independent Claim
171 words
An apparatus for rinsing and priming an exchanger, the exchanger having a first end and a second end and divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising: a source of sterile physiological saline solution; means for collecting said saline solution; an intake opening and an outlet opening formed in said first compartment; an intake opening and an outlet opening formed in said second compartment; first conduit means for flow communicating said intake opening of said first compartment to said source of sterile solution; second conduit means for flow communicating said outlet opening of said first compartment to said outlet opening of said second compartment; third conduit means for evacuating a portion of the sterile solution flowing through said second conduit means from said second conduit means to said collecting means; and fourth conduit means for flow communicating said inlet opening of said second compartment with said collecting means.
Claim 8
Independent Claim
171 words
An apparatus for rinsing and priming an exchanger, the exchanger having a first end and a second end and divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising: a source of sterile physiological saline solution; means for collecting said saline solution; an intake opening and an outlet opening formed in said first compartment; an intake opening and an outlet opening formed in said second compartment; first conduit means for flow communicating said intake opening of said first compartment to said source of sterile solution; second conduit means for flow communicating said outlet opening of said first compartment to said outlet opening of said second compartment; third conduit means for evacuating a portion of the sterile solution flowing through said second conduit means from said second conduit means to said collecting means; and fourth conduit means for flow communicating said inlet opening of said second compartment with said collecting means.
Claim 9
Dependent Claim
32 words
The apparatus of claim 6, wherein the third conduit means includes obturation means for selectively passing said solution into the second compartment upon sensing a predetermined pressure in said second conduit means.
Claim 10
Dependent Claim
31 words
The apparatus of claim 6, wherein the collecting means includes a first receptacle for connection to said third conduit means and a second receptacle for connection to said fourth conduit means.
Claim 11
Dependent Claim
41 words
The apparatus of claim 6, wherein said first conduit means is connected to said first compartment proximate the first end of the apparatus and said second conduit means is connected to said second compartment proximate the first end of the apparatus.
Claim 12
Dependent Claim
38 words
The apparatus of claim 6, wherein said second conduit means is connected between said first and second compartments to direct fluid flow through said second compartment in substantially the same direction as fluid flow through said first compartment.
Claim 13
Independent Claim
165 words
An apparatus for rinsing and priming an exchanger, the exchanger having a first end and a second end and divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising: a source of sterile physiological saline solution; means for collecting said saline solution; first and second openings formed in said first compartment; first and second openings formed in said second compartment; first conduit means for flow communicating said first opening of said first compartment to said source of sterile solution; second conduit means for flow communicating said second opening of said first compartment to said first opening of said second compartment; third conduit means for evacuating a portion of the sterile solution flowing through said second conduit means from said second conduit means to said collecting means; and fourth conduit means for flow communicating said second opening of said second compartment with said collecting means.
Claim 14
Independent Claim
165 words
An apparatus for rinsing and priming an exchanger, the exchanger having a first end and a second end and divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising: a source of sterile physiological saline solution; means for collecting said saline solution; first and second openings formed in said first compartment; first and second openings formed in said second compartment; first conduit means for flow communicating said first opening of said first compartment to said source of sterile solution; second conduit means for flow communicating said second opening of said first compartment to said first opening of said second compartment; third conduit means for evacuating a portion of the sterile solution flowing through said second conduit means from said second conduit means to said collecting means; and fourth conduit means for flow communicating said second opening of said second compartment with said collecting means.
Claim 15
Dependent Claim
38 words
The apparatus of claim 11, wherein said second conduit means is connected between said first and second compartments to direct fluid flow through said second compartment in substantially the same direction as fluid flow through said first compartment.
Claim 16
Independent Claim
93 words
A method for rinsing and priming an exchanger divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising the steps of: (a) circulating a sterile solution through the first compartment to rinse the same; (b) circulating a sterile solution through the second compartment to rinse the same; and (c) depositing a protein film on at least one side of the semi-permeable membrane by circulating a sterile albumin solution through the second compartment.
Claim 17
Independent Claim
93 words
A method for rinsing and priming an exchanger divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising the steps of: (a) circulating a sterile solution through the first compartment to rinse the same; (b) circulating a sterile solution through the second compartment to rinse the same; and (c) depositing a protein film on at least one side of the semi-permeable membrane by circulating a sterile albumin solution through the second compartment.
Claim 18
Independent Claim
105 words
A method for rinsing and priming an exchanger divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising the steps of: (a) circulating a sterile solution through the first compartment to rinse the same; (b) circulating a sterile solution through the second compartment to rinse the same; and (c) circulating blood to be treated through the first compartment to deposit a protein film on the membrane while maintaining the sterile solution in the second compartment after rinsing the first compartment with the sterile solution.
Claim 19
Independent Claim
105 words
A method for rinsing and priming an exchanger divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising the steps of: (a) circulating a sterile solution through the first compartment to rinse the same; (b) circulating a sterile solution through the second compartment to rinse the same; and (c) circulating blood to be treated through the first compartment to deposit a protein film on the membrane while maintaining the sterile solution in the second compartment after rinsing the first compartment with the sterile solution.
Claim 20
Dependent Claim
21 words
The method of claim 14, wherein the sterile solution circulating through the first and second compartments originates from the same source.
Claim 21
Dependent Claim
15 words
A method according to claim 14, wherein the sterile solutions are heparinized physiological saline solutions.
Claim 22
Independent Claim
104 words
A method for rinsing and priming an exchanger divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising the steps of: (a) circulating a sterile solution through the first compartment to rinse the same; (b) concurrently circulating a sterile solution through the second compartment to rinse the same; and (c) circulating blood to be treated through the first compartment to deposit a protein film on the membrane while maintaining the sterile solution in the second compartment after rinsing the first and second compartments.
Claim 23
Independent Claim
104 words
A method for rinsing and priming an exchanger divided into first and second compartments by a semi-permeable membrane, the first compartment intended for circulating blood to be treated and the second compartment intended for circulating a purifying liquid, comprising the steps of: (a) circulating a sterile solution through the first compartment to rinse the same; (b) concurrently circulating a sterile solution through the second compartment to rinse the same; and (c) circulating blood to be treated through the first compartment to deposit a protein film on the membrane while maintaining the sterile solution in the second compartment after rinsing the first and second compartments.
Claim 24
Dependent Claim
18 words
The method of claim 17, wherein sterile solution exiting the first compartment is directed through the second compartment.
Claim 25
Dependent Claim
57 words
The method of claim 17, wherein the step of circulating sterile liquid through the second compartment includes the substep of: (a) directing the sterile solution exiting the first compartment into and through the second compartment; (b) draining off a predetermined amount of the sterile solution prior to entering the second compartment and after exiting the first compartment.
Claim 26
Dependent Claim
33 words
The method according to claim 19, wherein the predetermined amount of sterile solution drained off comprises a first portion of sterile solution exiting the first compartment, said first portion being about 500 ml.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-01 | 1994-10-01 | 1995-04-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-01 | 1998-10-01 | 1999-04-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-01 | 2002-10-01 | 2003-04-02 | $7700.00 | Window Closed / Lapsed |