US5002873A
Expired / Lapsed
US
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DNA sequence encoding a lymphocyte adhesion receptor for high endothelium
Assignee: Fred Hutchinson Cancer Center
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Filing: 1989-03-17
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Granted: 1991-03-26
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Expires: 2009-03-17
Abstract
Abstract A lymphoid cell line cDNA that encodes an adhesion receptor for high endothelial venules (HEV).
Inventors
- 👤 Thomas P. St. John
- 👤 W. Michael Gallatin
- 👤 Rejean L. Idzerda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 18:03
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/705; C07K14/70503; C07K14/70532; A; A61; A61P; A61P31/00; C07K14/70585; C07K16/00; C07K16/18; C07K16/28; C07K16/2884; A61K; A61K38/00; C07K2319/00; C07K2319/32; C07K2319/61; Y; Y10; Y10S; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
32 words
An isolated DNA molecule capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 182 and 1207 inclusive of the baboon lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 2
Dependent Claim
32 words
An isolated DNA molecule capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 182 and 1207 inclusive of the baboon lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 3
Dependent Claim
35 words
The isolated DNA molecule of claim 1, which encodes for a polypeptide that is recognized by a binding partner specific for a glycoprotein lymphocyte surface receptor for high-walled endothelial venule (HEV) determinants in postcapillary venules.
Claim 4
Dependent Claim
28 words
The isolated DNA molecule of claim 1, which encodes for a polypeptide that is recognized by a binding partner specific for the Class III extracellular matrix receptor (ECMRIII).
Claim 5
Dependent Claim
24 words
The isolated DNA molecule of claim 1, which encodes for a polypeptide that is recognized by a binding partner specific for the CD44 molecule.
Claim 6
Dependent Claim
41 words
The isolated DNA molecule of claim 1, capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 182 and 991 inclusive of the extracellular and transmembrane domains of the baboon lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 7
Dependent Claim
38 words
The isolated DNA molecule of claim 1, capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 182 and 931 inclusive of the extracellular domain of the lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 8
Dependent Claim
35 words
An isolated DNA molecule capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 932 and 991 inclusive of the transmembrane domain of the lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 9
Dependent Claim
35 words
An isolated DNA molecule capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 932 and 991 inclusive of the transmembrane domain of the lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 10
Dependent Claim
37 words
An isolated DNA molecule capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 932 and 1207 inclusive of the transmembrane and cytoplasmic domains of the lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 11
Dependent Claim
37 words
An isolated DNA molecule capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 932 and 1207 inclusive of the transmembrane and cytoplasmic domains of the lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 12
Dependent Claim
35 words
An isolated DNA molecule capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 992 and 1207 inclusive of the cytoplasmic domain of the lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 13
Dependent Claim
35 words
An isolated DNA molecule capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 992 and 1207 inclusive of the cytoplasmic domain of the lymphocyte adhesion receptor gene shown in FIG. 4.
Claim 14
Dependent Claim
22 words
A recombinant expression vector comprising at least one strand of the DNA molecule of claim 1 operably linked to suitable control sequences.
Claim 15
Dependent Claim
10 words
Cells transfected with the recombinant expression vector of claim 10.
Claim 16
Dependent Claim
46 words
A method of producing a polypeptide that is recognized by a binding partner specific for a lymphocyte surface receptor for high-walled endothelial venule (HEV) determinants in postcapillary venules, the method comprising culturing the cells of claim 11 under conditions effective for the production of said polypeptide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-03-25 | 1994-09-24 | 1995-03-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-25 | 1998-09-24 | 1999-03-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-25 | 2002-09-24 | 2003-03-26 | $7700.00 | Window Closed / Lapsed |