US5002071A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Injectable soft tissue augmentation materials from the placenta and their method of manufacture
Assignee: Research Development Foundation
•
Filing: 1989-09-27
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Granted: 1991-03-26
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Expires: 2009-09-27
Abstract
Abstract Disclosed is a soft tissue augmentation material from human placenta homogenized to pass through a surgical needle, preferably a 30 gauge surgical needle, and cross-linking collagen molecules of the material by gamma irradiation. Also disclosed are methods of making the injectable soft tissue augmentation material and using it in human beings.
Inventors
- 👤 Carl R. Harrell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 23:16
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61K; A61K35/00; A61K35/12; A61K35/48; A61K35/50; A61L27/50; A61L2400/00; A61L2400/06
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
45 words
An injectable soft tissue augmentation material comprising, a sterilized mixture of type I and type III collagen extracted by proteolytic digestion from the group consisting of insoluble amnion, soluble amnion, soluble chorion from human placenta and combinations thereof, homogenized to pass through a surgical needle.
Claim 2
Dependent Claim
45 words
An injectable soft tissue augmentation material comprising, a sterilized mixture of type I and type III collagen extracted by proteolytic digestion from the group consisting of insoluble amnion, soluble amnion, soluble chorion from human placenta and combinations thereof, homogenized to pass through a surgical needle.
Claim 3
Dependent Claim
22 words
The injectable soft tissue augmentation material of claim 1 where, the collagen is homogenized to pass through a 30 gauge surgical needle.
Claim 4
Dependent Claim
17 words
The injectable soft tissue augmentation material of claim 1 where, the selected collagen is from soluble amnion.
Claim 5
Dependent Claim
17 words
The injectable soft tissue augmentation material of claim 1 where, the collagen is cross-linked by gamma irradiation.
Claim 6
Dependent Claim
20 words
The injectable soft tissue augmentation material of claim I where, the gamma irradiation is a minimum of 0.20 M rads.
Claim 7
Dependent Claim
26 words
The injectable soft tissue augmentation material of claim 4 where, the gamma irradiation is in the range of from 0.25 M rads to 2.0 M rads.
Claim 8
Dependent Claim
12 words
The injectable soft tissue augmentation material of claim I includes, an analgesic.
Claim 9
Independent Claim
57 words
A method of making an injectable soft tissue material comprising, sterilizing a mixture of type I and type III collagen extracted by pepsin digestion selected from the group consisting of insoluble amnion, soluble amnion, soluble chorion from human placenta and combinations thereof, and homogenizing the material sufficiently to pass through at least a 25 gauge surgical needle.
Claim 10
Independent Claim
57 words
A method of making an injectable soft tissue material comprising, sterilizing a mixture of type I and type III collagen extracted by pepsin digestion selected from the group consisting of insoluble amnion, soluble amnion, soluble chorion from human placenta and combinations thereof, and homogenizing the material sufficiently to pass through at least a 25 gauge surgical needle.
Claim 11
Dependent Claim
21 words
The method of making the injectable soft tissue material of claim 8 comprising, cross-linking molecules of the collagen by gamma irradiation.
Claim 12
Dependent Claim
16 words
The method of claim 9 where, the gamma irradiation is a minimum of 0.20 M rads.
Claim 13
Dependent Claim
21 words
The method of claim 9 where, the gamma irradiation is in the range of 0.25 M rads to 2.0 M rads.
Claim 14
Dependent Claim
20 words
The method of making the injectable soft tissue material of claim 8 including, adding an analgesic to the homogenized collagen.
Claim 15
Dependent Claim
21 words
A method of augmenting soft tissue in a human being comprising, injecting into the human being the collagen of claim 1.
Claim 16
Dependent Claim
21 words
A method of augmenting soft tissue in a human being comprising, injecting into the human being the collagen of claim 2.
Claim 17
Dependent Claim
21 words
A method of augmenting soft tissue in a human being comprising, injecting into the human being the collagen of claim 3.
Claim 18
Dependent Claim
21 words
A method of augmenting soft tissue in a human being comprising, injecting into the human being the collagen of claim 4.
Claim 19
Dependent Claim
21 words
A method of augmenting soft tissue in a human being comprising, injecting into the human being the collagen of claim 5.
Claim 20
Dependent Claim
21 words
A method of augmenting soft tissue in a human being comprising, injecting into the human being the collagen of claim 6.
Claim 21
Dependent Claim
21 words
A method of augmenting soft tissue in a human being comprising, injecting into the human being the material of claim 7.
Claim 22
Dependent Claim
16 words
The injectable soft tissue augmentation material of claim 1 where, the proteolytic digestion is with pepsin.
Claim 23
Dependent Claim
21 words
A method of augmenting soft tissue in a human being comprising, injecting into the human being the collagen of claim 7.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-03-25 | 1994-09-24 | 1995-03-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-25 | 1998-09-24 | 1999-03-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-25 | 2002-09-24 | 2003-03-26 | $7700.00 | Window Closed / Lapsed |