US4998535A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thrombolysis predictive instrument
Assignee: WASHINGTON, University of
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Filing: 1989-09-05
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Granted: 1991-03-12
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Expires: 2009-09-05
Abstract
Abstract An instrument for predicting the benefit of using thrombolytic therapy to treat a patient with a heart condition including a first input port for receiving inputs derived from electrocardiograph measurements of the patient's condition, and a processor for computing an estimate of said benefit based upon the electrocardiograph-derived inputs.
Inventors
- 👤 Harry P. Selker
- 👤 Galen S. Wagner
- 👤 W. Douglas Weaver
- 👤 Robert M. Califf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 09:35
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/24; A61B5/316; A61B5/318; A61B5/346; A61B5/349; A61B5/48; A61B5/4836; A61B5/4839; A61B5/72; A61B5/7271; A61B5/7275; G; G16; G16H; G16H50/00; G16H50/30; A61B5/02; A61B5/021; A61B5/024
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
80 words
An instrument for evaluating whether to use thrombolytic therapy to treat a patient with a heart condition, the instrument comprising: a first input means adapted to be coupled to said patient for receiving electrocardiographic data from the patient before using thrombolytic therapy on said patient; and a processing means for computing a predicted benefit to the cardiovascular health of the patient as a consequence of using thrombolytic therapy on said patient, said predicted benefit being derived from said electrocardiographic data.
Claim 2
Dependent Claim
80 words
An instrument for evaluating whether to use thrombolytic therapy to treat a patient with a heart condition, the instrument comprising: a first input means adapted to be coupled to said patient for receiving electrocardiographic data from the patient before using thrombolytic therapy on said patient; and a processing means for computing a predicted benefit to the cardiovascular health of the patient as a consequence of using thrombolytic therapy on said patient, said predicted benefit being derived from said electrocardiographic data.
Claim 3
Dependent Claim
31 words
The instrument of claim 1 further comprising: an electrocardiograph for generating an electrocardiograph waveform for said patient; and a waveform analyzer for analyzing the electrocardiograph waveform and generating said electrocardiographic data.
Claim 4
Dependent Claim
53 words
The instrument of claim 2 wherein said processing means computes said predicted benefit by computing a first and a second probability of acute hospital mortality, the first probability being computed using an assumption that no thrombolytic therapy is applied and the second probability being computed using an assumption that thrombolytic therapy is applied.
Claim 5
Dependent Claim
40 words
The instrument of claim 3 wherein said processing means uses an empirically based mathematical model to compute the first and second probabilities of acute hospital mortality, said model being derived from data about patients to whom thrombolytic therapy was administered.
Claim 6
Dependent Claim
24 words
The instrument of claim 4 wherein said processing means uses a regression model to compute the first and second probabilities of acute hospital mortality.
Claim 7
Dependent Claim
26 words
The instrument of claim 5 wherein said processing means uses a multivariate logistic regression model to compute the first and second probabilities of acute hospital mortality.
Claim 8
Dependent Claim
45 words
The instrument of claim 3 further comprising a second input means for receiving clinical data inputs conveying clinical data about said patient and wherein said processing means is adapted to use said clinical data inputs along with said electrocardiographic data to compute said predicted benefit.
Claim 9
Dependent Claim
53 words
The instrument of claim 1 wherein said processing means computes said predicted benefit by computing a first and a second probability of acute hospital mortality, the first probability being computed using an assumption that no thrombolytic therapy is applied and the second probability being computed using an assumption that thrombolytic therapy is applied.
Claim 10
Dependent Claim
40 words
The instrument of claim 8 wherein said processing means uses an empirically based mathematical model to compute the first and second probabilities of acute hospital mortality, said model being derived from data about patients to whom thrombolytic therapy was administered.
Claim 11
Dependent Claim
24 words
The instrument of claim 9 wherein said processing means uses a regression model to compute the first and second probabilities of acute hospital mortality.
Claim 12
Dependent Claim
26 words
The instrument of claim 10 wherein said processing means uses a multivariate logistic regression model to compute the first and second probabilities of acute hospital mortality.
Claim 13
Dependent Claim
44 words
The instrument of claim 1 further comprising a second input means for receiving inputs relating to clinical data for the patient and wherein said processing means is adapted to use said clinical data inputs along with said electrocardiographic data to compute said predicted benefit.
Claim 14
Independent Claim
93 words
A method for determining whether to use thrombolytic therapy to treat a patient with a heart condition, the method comprising: using an electrocardiograph to measure the patient's condition before using thrombolytic therapy on said patient; generating input signals from electrocardiograph measurements of the patient's condition; using a processor to estimate a benefit to the cardiovascular health of the patient as a consequence of using thrombolytic therapy on said patient, said estimated benefit being derived from the electrocardiograph-derived inputs; and using the estimated benefit to decide whether to apply thrombolytic therapy to said patient.
Claim 15
Independent Claim
93 words
A method for determining whether to use thrombolytic therapy to treat a patient with a heart condition, the method comprising: using an electrocardiograph to measure the patient's condition before using thrombolytic therapy on said patient; generating input signals from electrocardiograph measurements of the patient's condition; using a processor to estimate a benefit to the cardiovascular health of the patient as a consequence of using thrombolytic therapy on said patient, said estimated benefit being derived from the electrocardiograph-derived inputs; and using the estimated benefit to decide whether to apply thrombolytic therapy to said patient.
Claim 16
Dependent Claim
39 words
The method of claim 13 wherein the step of using an electrocardiograph comprises generating an electrocardiograph waveform for said patient, and wherein the method further comprises using a waveform analyzer to generate the electrocardiograph-derived inputs from the electrocardiograph waveform.
Claim 17
Dependent Claim
51 words
The method of claim 13 wherein the processor estimates the benefit by computing a first and a second probability of acute hospital mortality, the first probability being computed using an assumption that no thrombolytic therapy is applied and the second probability being computed using an assumption that thrombolytic therapy is applied.
Claim 18
Dependent Claim
39 words
The method of claim 15 wherein the processor uses an empirically based mathematical model to compute the first and second probabilities of acute hospital mortality, said model being derived from data about patients to whom thrombolytic therapy was administered.
Claim 19
Dependent Claim
23 words
The method of claim 16 wherein the processor uses a regression model to compute the first and second probabilities of acute hospital mortality.
Claim 20
Dependent Claim
25 words
The method of claim 17 wherein the processor uses a multivariate logistic regression model to compute the first and second probabilities of acute hospital mortality.
Claim 21
Dependent Claim
36 words
The method of claim 13 further comprising supplying clinical data for the patient to the processor and wherein the processor is adapted to use said clinical data along with said electrocardiograph-derived inputs to estimate said benefit.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-03-11 | 1994-09-10 | 1995-03-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-11 | 1998-09-10 | 1999-03-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-11 | 2002-09-10 | 2003-03-12 | $7700.00 | Window Closed / Lapsed |