US4996004A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preparation of pharmaceutical or cosmetic dispersions
Assignee: Bayer AG
•
Filing: 1989-03-15
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Granted: 1991-02-26
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Expires: 2009-03-15
Abstract
Abstract The invention relates to a process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic phase which is insoluble or not completely soluble in water (oily phase) in which a pre-emulsion is prepared from the two phases by known emulsifying methods and in then pumped through a jet disperser, the temperature, the proportion of the aqueous and organic phases, and the pressure at the jet disperser being adjusted so that phase inversion of the emulsion is effected in the jet disperser at the same time as homogenization and fine dispersion, and in the course of which all the pressure energy is consumed in the dispersing zone and the dispersion leaves as a non-directional stream.
Inventors
- 👤 Manfred Bucheler
- 👤 Hans Gehringer
- 👤 Bernd Klinksiek
- 👤 Bernd Koglin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 18:44
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/02; A61K8/04; A61K8/06; A61K8/062; A61K9/00; A61K9/10; A61K9/107; A61Q; A61Q19/00; B; B01; B01F; B01F23/00; B01F23/40; B01F23/41; B01F25/00; B01F25/40; B01F25/45; B01F25/452; B01F25/4521; B01F25/45211; A61Q17/00; A61Q17/04; Y; Y10; Y10S; Y10S516/00; Y10S516/924; Y10S516/925
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
143 words
Process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic oily phase which is insoluble or not completely soluble in water, characterized in that a pre-emulsion is pumped through a jet disperser which consists of one or more jets, which are designed as capillary bores with a diameter of 0.5 to 0.8 mm and have a length to diameter ratio of 1.5 to 2 the temperature, the proportions of the aqueous phase and the organic phase and the pressure at the jet disperser being adjusted so that phase inversion of the emulsion is effected in the jet disperser at the same time as homogenization and fine dispersion, and in the course of which all the pressure energy is consumed in the dispersing zone and the dispersion leaves the dispersing zone as a non-directional stream.
Claim 2
Dependent Claim
143 words
Process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic oily phase which is insoluble or not completely soluble in water, characterized in that a pre-emulsion is pumped through a jet disperser which consists of one or more jets, which are designed as capillary bores with a diameter of 0.5 to 0.8 mm and have a length to diameter ratio of 1.5 to 2 the temperature, the proportions of the aqueous phase and the organic phase and the pressure at the jet disperser being adjusted so that phase inversion of the emulsion is effected in the jet disperser at the same time as homogenization and fine dispersion, and in the course of which all the pressure energy is consumed in the dispersing zone and the dispersion leaves the dispersing zone as a non-directional stream.
Claim 3
Dependent Claim
32 words
A process according to claim 1, wherein to prepare the pre-emulsion, the organic phase is initially introduced as the external phase and the aqueous phase is emulsified therein as the internal phase.
Claim 4
Dependent Claim
26 words
A process according to claim 2, wherein the phase inversion is carried out as a concentration of 50 to 70% by weight of the organic phase.
Claim 5
Dependent Claim
23 words
A process according to claim 1, wherein the pre-emulsion is pumped through the jet disperser under a pressure of 2 to 50 bar.
Claim 6
Dependent Claim
71 words
A process according to claim 1, wherein the organic phase contains a mixture of glycerol esters or fatty acid esters and/or liquid, semi-solid and solid hydrocarbons, as well as polyhydric alcohols, non-ionic emulsifiers and fat-soluble pharmaceutical or cosmetic active compounds, and the aqueous phase contains an aqueous solution of glycerol, glycols, low-molecular monohydric alcohols and cosmetic or pharmaceutical active compounds, with the addition of substances which increase the viscosity and preservatives.
Claim 7
Dependent Claim
23 words
A process according to claim 1, wherein the pre-emulsion is pumped through the jet disperser under a pressure of 10 to 50 bar.
References Cited (Backward Citations)
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US2254049A
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US2524590A
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US2665206A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-02-25 | 1994-08-27 | 1995-02-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-02-25 | 1998-08-27 | 1999-02-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-02-25 | 2002-08-27 | 2003-02-26 | $7700.00 | Window Closed / Lapsed |