US4994438A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Heat treatment of lyophilized plasma fractions
Assignee: ESTATE OF ALAN I RUBINSTEIN AKA ALAN I RUBINSTEIN ASA ALAN RUBINSTEIN
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Filing: 1988-12-23
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Granted: 1991-02-19
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Expires: 2008-12-23
Abstract
Abstract The invention is directed to Factor VIII concentrate which has been heated in the lyophilized state at a temperature of at least 60 DEG C. for at least 10 hours to rid the factor of undesirable microorganisms.
Inventors
- 👤 Alan Rubinstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 09:57
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/644; A; A61; A61L; A61L2/00; A61L2/02; A61L2/04; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; C12Y; C12Y304/00; C12Y304/21; C12Y304/21022; A61L2103/00; A61L2103/05; A61L2103/09
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
62 words
A composition intended for therapeutic administration to hemophiliacs, said composition comprising a human Factor VIII concentrate which has been heated in the lyophilized state to a predetermined temperature of at least 60° C. for at least 10 hours with a clotting activity recovery of at least about 90% as compared with the activity of the human Factor VIII concentrate prior to heating.
Claim 2
Dependent Claim
62 words
A composition intended for therapeutic administration to hemophiliacs, said composition comprising a human Factor VIII concentrate which has been heated in the lyophilized state to a predetermined temperature of at least 60° C. for at least 10 hours with a clotting activity recovery of at least about 90% as compared with the activity of the human Factor VIII concentrate prior to heating.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-02-18 | 1994-08-20 | 1995-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-02-18 | 1998-08-20 | 1999-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-02-18 | 2002-08-20 | 2003-02-19 | $7700.00 | Window Closed / Lapsed |