US4992257A
Expired / Lapsed
US
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Dihydroporphyrins and method of treating tumors
Assignee: Efamol Holdings PLC
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Filing: 1989-03-02
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Granted: 1991-02-12
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Expires: 2009-03-02
Abstract
Abstract This invention provides novel compounds for therapy of tumours suceptible to necrosis when an appropriate compound is adminstered followed by illumination with light of a wavelength absorbed by the compound, the compounds being dihydro porphyrins of the formula, or the corresponding tetra-hydro porphyrins: <CHEM> where n = 1 to 3 and each substituent R, the same or different and at the same or different position in its respective substituent phenyl ring, is an hydroxy group.
Inventors
- 👤 Raymond Bonnett
- 👤 Morris C. Berenbaum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:32
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/22; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61P; A61P35/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
57 words
A compound of the formula: ##STR10## or the corresponding tetra-hydroporphyrins, where n-1 to 3 and each substituent R, which may be the same or different and at the same or different position in its respective substituent phenyl ring, is a hydroxy group or a hydroxy group substituted with a C 1-4 alkyl or C 1-4 acyl group.
Claim 2
Dependent Claim
57 words
A compound of the formula: ##STR10## or the corresponding tetra-hydroporphyrins, where n-1 to 3 and each substituent R, which may be the same or different and at the same or different position in its respective substituent phenyl ring, is a hydroxy group or a hydroxy group substituted with a C 1-4 alkyl or C 1-4 acyl group.
Claim 3
Dependent Claim
42 words
A compound of the formula: ##STR11## or the corresponding tetra-hydroporphyrins, where n=1 to 3 and each substituent R, which may be the same or different and at the same or different position in its respective substituent phenyl ring, is a hydroxy group.
Claim 4
Dependent Claim
42 words
A compound of the formula: ##STR11## or the corresponding tetra-hydroporphyrins, where n=1 to 3 and each substituent R, which may be the same or different and at the same or different position in its respective substituent phenyl ring, is a hydroxy group.
Claim 5
Dependent Claim
17 words
A compound according to claim 1, wherein each group Ar is an o-hydroxyphenyl, m-hydroxyphenyl, or p-hydroxyphenyl group.
Claim 6
Dependent Claim
19 words
A compound according to claim 1, wherein each hydroxy substituent is in free rather than in a substituted form.
Claim 7
Dependent Claim
11 words
A compound 2,3-dihydro-5,10,15,20-tetra(p-hydroxy-phenyl) porphyrin; 2,3-dihydro-5,10,15,20-tetra(m-hydroxy-phenyl) porphyrin; 2,3-dihydro-5,10,15,10-tetra(o-hydroxy-phenyl) porphyrin; or 7,8,17,18-tetrahydro-5,10,15,10-tetra(m-hydroxy-phenyl) porphyrin.
Claim 8
Dependent Claim
11 words
A compound 2,3-dihydro-5,10,15,20-tetra(p-hydroxy-phenyl) porphyrin; 2,3-dihydro-5,10,15,20-tetra(m-hydroxy-phenyl) porphyrin; 2,3-dihydro-5,10,15,10-tetra(o-hydroxy-phenyl) porphyrin; or 7,8,17,18-tetrahydro-5,10,15,10-tetra(m-hydroxy-phenyl) porphyrin.
Claim 9
Dependent Claim
22 words
A pharmaceutical composition for treating tumors comprising a tumor-locating porphyrin compound of claim 1, together with a pharmaceutically acceptable carrier or diluent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-02-11 | 1994-08-13 | 1995-02-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-02-11 | 1998-08-13 | 1999-02-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-02-11 | 2002-08-13 | 2003-02-12 | $7700.00 | Window Closed / Lapsed |