US4989649A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fill machine sterilization process
Assignee: Catalent Pharma Solutions LLC
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Filing: 1989-09-14
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Granted: 1991-02-05
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Expires: 2009-09-14
Abstract
Abstract A sterilizing method is provided for use with a container filling machine having components defining passages through which a fluid product flows. In one method aspect, sterilizing steam is passed through the components unitl the components have been sterilized. As the system cools and the steam condenses, the system is pressurized with gas to prevent the internal pressure in the system from decreasing below the ambient atmospheric pressure. In a further method aspect, the sterilizing process is controlled in response to sensing the temperature of one or more of the components. In yet another aspect, a common source of sterilizing steam is provided for being directed into the product filling system and simultaneously into an associated process gas supply system to sterilize both systems generally concurrently in a single pass.
Inventors
- 👤 Gerhard H. Weiler
- 👤 Arjun Ramrakhyani
- 👤 Paul A. Anderson
- 👤 Frank N. Leo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:16
CPC Classifications
B; B65; B65B; B65B55/00; B65B55/02; Y; Y10; Y10T; Y10T137/00; Y10T137/4238; Y10T137/4245; Y10T137/4266
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
101 words
A method for steam sterilization of product components defining fill product passages and of process gas components defining process gas passages in a container filling machine, said method comprising the steps of: (a) supplying a common source of sterilizing steam; (b) simultaneously directing some of said steam from said common source into said product passages and some of said steam from said common source into said process gas passages in a single pass; and (c) maintaining said steam in said product and process gas passages generally concurrently for a time period sufficient to sterilize said product components and process gas components.
Claim 2
Independent Claim
101 words
A method for steam sterilization of product components defining fill product passages and of process gas components defining process gas passages in a container filling machine, said method comprising the steps of: (a) supplying a common source of sterilizing steam; (b) simultaneously directing some of said steam from said common source into said product passages and some of said steam from said common source into said process gas passages in a single pass; and (c) maintaining said steam in said product and process gas passages generally concurrently for a time period sufficient to sterilize said product components and process gas components.
Claim 3
Independent Claim
154 words
A method for steam sterilization of product components defining fill product passages and of process gas components defining process gas passages in a container filling machine wherein one of said components has the relatively largest mass as compared to the other components, said method comprising the steps of: (a) supplying a common source of sterilizing steam; (b) directing said steam from said common source concurrently into said product passages and into said process gas passages in a single pass; (c) maintaining said steam in said product and process gas passages for a time period sufficient to sterilize said product and process gas components; (d) sensing the temperature of said one component having the largest mass; and (e) the additional step, after a predetermined first temperature has been sensed in said one component, of terminating steps (b) and (c) at the end of a predetermined time period following the sensing of said predetermined first temperature.
Claim 4
Independent Claim
154 words
A method for steam sterilization of product components defining fill product passages and of process gas components defining process gas passages in a container filling machine wherein one of said components has the relatively largest mass as compared to the other components, said method comprising the steps of: (a) supplying a common source of sterilizing steam; (b) directing said steam from said common source concurrently into said product passages and into said process gas passages in a single pass; (c) maintaining said steam in said product and process gas passages for a time period sufficient to sterilize said product and process gas components; (d) sensing the temperature of said one component having the largest mass; and (e) the additional step, after a predetermined first temperature has been sensed in said one component, of terminating steps (b) and (c) at the end of a predetermined time period following the sensing of said predetermined first temperature.
Claim 5
Independent Claim
138 words
A method for steam sterilization of product components defining fill product passages and of process gas components defining process gas passages in a container filling machine, said method comprising the steps of: (a) supplying a common source of sterilizing steam; (b) directing said steam from said common source concurrently into said product passages and into said process gas passages in a single pass; (c) maintaining said steam in said product and process gas passages for a time period sufficient to sterilize said product and process gas components; and (d) terminating step (c) and introducing a sterile gas into said product and process gas passages as said product and process gas components cool and cause steam to condense therewithin so as to maintain the internal pressure in said product and process gas passages at least at ambient atmospheric pressure.
Claim 6
Independent Claim
138 words
A method for steam sterilization of product components defining fill product passages and of process gas components defining process gas passages in a container filling machine, said method comprising the steps of: (a) supplying a common source of sterilizing steam; (b) directing said steam from said common source concurrently into said product passages and into said process gas passages in a single pass; (c) maintaining said steam in said product and process gas passages for a time period sufficient to sterilize said product and process gas components; and (d) terminating step (c) and introducing a sterile gas into said product and process gas passages as said product and process gas components cool and cause steam to condense therewithin so as to maintain the internal pressure in said product and process gas passages at least at ambient atmospheric pressure.
Claim 7
Dependent Claim
68 words
The method in accordance with claim 3 including the further steps of (1) sensing the temperature in one of said product and process gas components, (2) performing step (c) for a time period beginning with the sensing of a predetermined first temperature, and (3) terminating said step of introducing said sterile gas after sensing in said one component a predetermined second temperature lower than said predetermined first temperature.
Claim 8
Dependent Claim
31 words
The method in accordance with claim 3 in which said step of introducing said sterile gas includes maintaining said sterile gas in said product and process gas passages at above-atmospheric pressure.
Claim 9
Dependent Claim
32 words
The method in accordance with claim 3 in which said step of introducing said sterile gas includes first directing a non-sterile gas through a sterilizing filter into product and process gas passages.
Claim 10
Dependent Claim
88 words
The method in accordance with claim 1 in which said components defining said fill product passages are part of a product filling system, in which said process gas components defining said process gas passages are part of a process gas supply system, and in which step (b) includes (1) opening a communicating passage between said product filling system and said process gas supply system and (2) directing a flow of said sterilizing steam from said common source into said communicating passage for supplying both of said systems concurrently.
Claim 11
Independent Claim
87 words
A method for steam sterilization of components of a container filling machine, said method comprising the steps of: (a) providing a source of sterilizing steam to flow through passages defined by said components to heat said components to a sterilizing temperature for a period of time to sterilize said components; and (b) introducing a sterile gas into said passages as said components cool and cause said steam to condense therewithin so as to prevent the internal pressure in said passages from decreasing below the ambient atmospheric pressure.
Claim 12
Independent Claim
87 words
A method for steam sterilization of components of a container filling machine, said method comprising the steps of: (a) providing a source of sterilizing steam to flow through passages defined by said components to heat said components to a sterilizing temperature for a period of time to sterilize said components; and (b) introducing a sterile gas into said passages as said components cool and cause said steam to condense therewithin so as to prevent the internal pressure in said passages from decreasing below the ambient atmospheric pressure.
Claim 13
Dependent Claim
23 words
The method in accordance with claim 8 in which step (a) includes causing said stem to flow through said passages at above-atmospheric pressure.
Claim 14
Dependent Claim
17 words
The method in accordance with claim 8 in which step (a) includes draining condensate from said passages.
Claim 15
Dependent Claim
36 words
The method in accordance with claim 8 in which said method includes terminating step (a) after said components have been sterilized and in which step (b) includes introducing said gas after step (a) has been terminated.
Claim 16
Dependent Claim
28 words
The method in accordance with claim 8 in which step (b) includes introducing said gas by first directing a non-sterile gas through a sterilizing filter into said passages.
Claim 17
Independent Claim
103 words
A method for steam sterilization having a plurality of components wherein one of said components has the relatively largest mass as compared to the other components of a container filling machine, said method comprising the steps of: (a) supplying sterilizing steam to the components of said machine to flow through passages defined by said components to heat said components to a sterilizing temperature; (b) sensing a temperature of said one component having the relatively largest mass; and (c) terminating step (a) after a predetermined first temperature has been sensed in step (b) and maintained for a period of time to sterilize said components.
Claim 18
Independent Claim
103 words
A method for steam sterilization having a plurality of components wherein one of said components has the relatively largest mass as compared to the other components of a container filling machine, said method comprising the steps of: (a) supplying sterilizing steam to the components of said machine to flow through passages defined by said components to heat said components to a sterilizing temperature; (b) sensing a temperature of said one component having the relatively largest mass; and (c) terminating step (a) after a predetermined first temperature has been sensed in step (b) and maintained for a period of time to sterilize said components.
Claim 19
Dependent Claim
17 words
The method in accordance with claim 13 in which step (a) includes draining condensate from said passages.
Claim 20
Dependent Claim
43 words
The method in accordance with claim 13 in which step (a) includes supplying said steam for a predetermined time period following the sensing of said predetermined first temperature; and step (c) includes terminating step (a) at the end of said predetermined time period.
Claim 21
Dependent Claim
46 words
The method in accordance with claim 13 including the further step (d) of introducing sterile gas into said passages as said components cool and cause steam to condense therewithin so as to maintain the internal pressure in said passages at least at the ambient atmospheric pressure.
Claim 22
Dependent Claim
31 words
The method in accordance with claim 16 including the further step (e) of terminating step (d) after sensing in step (b) a predetermined second temperature lower than said predetermined first temperature.
Claim 23
Dependent Claim
24 words
The method in accordance with claim 16 in which step (d) includes first directing a non-sterile gas through a sterilizing filter into said passages.
Claim 24
Independent Claim
80 words
A method for steam sterilization of components of a container filling machine, said method comprising the steps of: (a) supplying sterilizing steam to the components of said machine to flow through passages defined by said components to heat said components to a sterilizing temperature; (b) sensing a temperature of one of said components; and (c) terminating first step (a) after a predetermined temperature has been sensed in step (b) and maintained for a period of time to sterilize said components.
Claim 25
Independent Claim
80 words
A method for steam sterilization of components of a container filling machine, said method comprising the steps of: (a) supplying sterilizing steam to the components of said machine to flow through passages defined by said components to heat said components to a sterilizing temperature; (b) sensing a temperature of one of said components; and (c) terminating first step (a) after a predetermined temperature has been sensed in step (b) and maintained for a period of time to sterilize said components.
Claim 26
Independent Claim
122 words
A method for steam sterilization of components of a container filling machine, said method comprising the steps of: (a) supplying sterilizing steam to the components of said machine to flow through passages defined by said components to heat said components to a sterilizing temperature; (b) sensing a temperature of the component having the relatively largest mass as compared to the other components; (c) terminating step (a) after a predetermined temperature has been sensed in step (b) and maintained for a period of time to sterilize said components; and (d) introducing sterile gas into said passages as said components cool and cause steam to condense therewithin so as to prevent the internal pressure in said passages from decreasing below the ambient atmospheric pressure.
Claim 27
Independent Claim
122 words
A method for steam sterilization of components of a container filling machine, said method comprising the steps of: (a) supplying sterilizing steam to the components of said machine to flow through passages defined by said components to heat said components to a sterilizing temperature; (b) sensing a temperature of the component having the relatively largest mass as compared to the other components; (c) terminating step (a) after a predetermined temperature has been sensed in step (b) and maintained for a period of time to sterilize said components; and (d) introducing sterile gas into said passages as said components cool and cause steam to condense therewithin so as to prevent the internal pressure in said passages from decreasing below the ambient atmospheric pressure.
References Cited (Backward Citations)
US2787875A
Cited
US3650678A
Cited
US3791424A
Cited
US3850207A
Cited
US3912535A
Cited
US4218265A
Cited
US4347877A
Cited
US4353398A
Cited
US4502614A
Cited
US4623516A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-02-04 | 1994-08-06 | 1995-02-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-02-04 | 1998-08-06 | 1999-02-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-02-04 | 2002-08-06 | 2003-02-05 | $7700.00 | Window Closed / Lapsed |