US4988728A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Suprofen esters and amides as ophthalmic anti-inflammatory agents
Assignee: Alcon Vision LLC
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Filing: 1990-07-23
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Granted: 1991-01-29
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Expires: 2010-07-23
Abstract
Abstract Disclosed are esters and amides of suprofen having enhanced delivery characteristics on topical administration to the eye; also disclosed are pharmaceutical compositions comprising such suprofen derivatives and methods of using them when indicated to achieve an anti-inflammatory effect on topical delivery to the eye.
Inventors
- 👤 Steven H. Gerson
- 👤 Wesley W. Han
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 23:55
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/22
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
33 words
A compound of the following formula: ##STR2## wherein R is selected from the group consisting of alkoxyl and hydroxyalkoxyl of 3 to 8 carbon atoms and alkylamino of 3 to 8 carbon atoms.
Claim 2
Dependent Claim
33 words
A compound of the following formula: ##STR2## wherein R is selected from the group consisting of alkoxyl and hydroxyalkoxyl of 3 to 8 carbon atoms and alkylamino of 3 to 8 carbon atoms.
Claim 3
Dependent Claim
13 words
A compound according to claim 1 which is the pentanediol ester of suprofen.
Claim 4
Dependent Claim
13 words
A compound according to claim 1 which is the butylamine amide of suprofen.
Claim 5
Dependent Claim
22 words
An ophthalmic, anti-inflammatory composition for topical application to the eye comprising a therapeutically effective amount of a compound according to claim 1.
Claim 6
Dependent Claim
49 words
An ophthalmic, anti-inflammatory composition for topical application to the eye comprising an aqueous solution containing from about 0.1% to about 4.0% by weight of an amide or ester of suprofen and from about 0.5% to about 3.0% by weight of a polyoxypropylene having a polyoxyethylene group at either end.
Claim 7
Dependent Claim
49 words
An ophthalmic, anti-inflammatory composition for topical application to the eye comprising an aqueous solution containing from about 0.1% to about 4.0% by weight of an amide or ester of suprofen and from about 0.5% to about 3.0% by weight of a polyoxypropylene having a polyoxyethylene group at either end.
Claim 8
Dependent Claim
18 words
A composition according to claim 5 wherein the ester or amide is the pentanediol ester or butylamine amide.
Claim 9
Dependent Claim
17 words
A method for the treatment of ophthalmic inflammation which comprises administration of a composition of claim 5.
Claim 10
Dependent Claim
18 words
A method according to claim 7 wherein the ester or amide is the pentanediol ester or butylamine amide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-01-28 | 1994-07-30 | 1995-01-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-01-28 | 1998-07-30 | 1999-01-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-01-28 | 2002-07-30 | 2003-01-29 | $7700.00 | Window Closed / Lapsed |