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US4980473A Expired / Lapsed US ⏱️ 0.0 years remaining

Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents

Assignee: Columbia University
•
Filing: 1987-07-22
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Granted: 1990-12-25
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Expires: 2007-07-22
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Abstract

Abstract This invention concerns a coordination complex and salts and optically resolved enantiomers thereof, of the formula (R)3-M, wherein R comprises 1,10-phenanthroline or a substituted derivative thereof, M comprises a suitable transition metal, e.g. ruthenium(II) or cobalt(III), and R is bonded to M by a coordination bond. The complexes of this invention are useful in methods for labeling, nicking and cleaving DNA. The lambda enantiomer of complexes of this invention is useful in methods for specifically labeling, detecting, nicking and cleaving Z-DNA. The complexes may also be used in a method for killing tumor cells and may be combined with a pharmaceutically acceptable carrier to form a pharmaceutical composition for the treatment of tumor cells in a subject. The invention further concerns methods for treating a subject afflicted with tumor cells.

Inventors

  • 👤 Jacqueline K. Barton

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 18:55
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; C07F; C07F15/00; C07F15/06; C07F15/065; C07H; C07H21/00; C07H23/00; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813; C12Q1/6816

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 50 words
A coordination complex having the formula (R)3 --- CO(III), wherein R is 1,10-phenanthroline or a substituted derivative thereof selected from the group consisting of 4,7-diamino-1,10-phenanthroline; 3,8-diamono-1,10-phenanthroline; 4,7-diethylenediamine-1,10-phenanthroline; 3,8-diethylenediamine-1,10-phenanthroline; 4,7-dihydroxyl-1,10-phenanthroline; 3,8-dihydroxy-1,10-phenanthroline; 4,7-dinitro-1,10-phenanthroline; 3,8-dinitro-1,10-phenanthroline; 4,7-diphenyl-1,10-phenanthroline; 3,8-diphenyl-1,10-phenanthroline; 4,7-dispermine-1,10-phenanthroline; and 3,8-dispermine1,10-phenanthroline; and R is bound to Co by a coordination bond or salt thereof.
Claim 2
Dependent Claim 50 words
A coordination complex having the formula (R)3 --- CO(III), wherein R is 1,10-phenanthroline or a substituted derivative thereof selected from the group consisting of 4,7-diamino-1,10-phenanthroline; 3,8-diamono-1,10-phenanthroline; 4,7-diethylenediamine-1,10-phenanthroline; 3,8-diethylenediamine-1,10-phenanthroline; 4,7-dihydroxyl-1,10-phenanthroline; 3,8-dihydroxy-1,10-phenanthroline; 4,7-dinitro-1,10-phenanthroline; 3,8-dinitro-1,10-phenanthroline; 4,7-diphenyl-1,10-phenanthroline; 3,8-diphenyl-1,10-phenanthroline; 4,7-dispermine-1,10-phenanthroline; and 3,8-dispermine1,10-phenanthroline; and R is bound to Co by a coordination bond or salt thereof.
Claim 3
Dependent Claim 11 words
The optically resolved Δ isomer of a complex of claim 1.
Claim 4
Dependent Claim 11 words
The optically resolved Λ isomer of a complex of claim 1.

References Cited (Backward Citations)

No citation records indexed.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1993-12-24 1994-06-25 1994-12-25 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1997-12-24 1998-06-25 1998-12-25 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2001-12-24 2002-06-25 2002-12-25 $7700.00 Window Closed / Lapsed

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