US4973552A
Expired / Lapsed
US
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Staurosporine fermentation process
Assignee: Bristol Myers Squibb Co
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Filing: 1990-02-20
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Granted: 1990-11-27
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Expires: 2010-02-20
Abstract
Abstract A fermentation process for preparing staurosporine, a known antibiotic, employing a heretofore unknown micrrorganism is described, said microorganism being classified as a novel strain of Streptomyces hygroscopicus being and herein designated Streptomyces hygroscopicus strain C39280-450-9 (ATCC 53730).
Inventors
- 👤 Daniel R. Schroeder
- 👤 Kin S. Lam
- 👤 Jacqueline M. Mattei
- 👤 Grace A. Hesler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 11:47
CPC Classifications
C; C12; C12P; C12P17/00; C12P17/18; C12P17/188; C12N; C12N1/00; C12N1/20; C12N1/205; C12R; C12R2001/00; C12R2001/01; C12R2001/465; C12R2001/55; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/898
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
68 words
A process for the production of staurosporine which comprises cultivating a staurosporine-producing strain of Streptomyces hygroscopicus in an aqueous nutrient medium under submerged aerobic conditions until a substantial amount of staurosporine is produced by said organism in said culture medium and recovering the staurosporine from the culture medium substantially free of co-produced substances wherein the organism is Steptomyces hygroscopicus strain C3920-450-9 (ATCC 53730), a mutant or variant thereof.
Claim 2
Dependent Claim
68 words
A process for the production of staurosporine which comprises cultivating a staurosporine-producing strain of Streptomyces hygroscopicus in an aqueous nutrient medium under submerged aerobic conditions until a substantial amount of staurosporine is produced by said organism in said culture medium and recovering the staurosporine from the culture medium substantially free of co-produced substances wherein the organism is Steptomyces hygroscopicus strain C3920-450-9 (ATCC 53730), a mutant or variant thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-26 | 1994-05-28 | 1994-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-26 | 1998-05-28 | 1998-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-26 | 2002-05-28 | 2002-11-27 | $7700.00 | Window Closed / Lapsed |