US4970237A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of clomiphene to increase bone mass in premenopausal women
Assignee: Yale University
•
Filing: 1989-02-14
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Granted: 1990-11-13
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Expires: 2009-02-14
Abstract
Abstract This invention relates to the use of clomiphene in preventing osteoporosis in humans and treating human patients experiencing osteoporosis.
Inventors
- 👤 Pamela S. Jensen
- 👤 Florence Comite
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 08:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
33 words
A method of preventing oseteoporosis in premenopausal women comprising administering to a premenopausal woman an effective osteoporosis preventing amount of clomiphene or its citrate salt, either alone or in admixture with a diluent.
Claim 2
Independent Claim
33 words
A method of preventing oseteoporosis in premenopausal women comprising administering to a premenopausal woman an effective osteoporosis preventing amount of clomiphene or its citrate salt, either alone or in admixture with a diluent.
Claim 3
Dependent Claim
16 words
A method according to claim 1, wherein said clomiphene is in the form of clomiphene citrate.
Claim 4
Dependent Claim
12 words
A method according to claim 1, wherein said clomiphene is administered daily.
Claim 5
Dependent Claim
36 words
A method according to claim 3, wherein the clomiphene is administered in an amount of 0.01 to 10 mg/kg of body weight for intravenous administration and 0.05 to 20 mg/kg of body weight for oral administration.
Claim 6
Dependent Claim
36 words
A method according to claim 3, wherein the clomiphene is administered in an amount of 0.05 to 5 mg/kg of body weight for intravenous administration and 0.5 to 5 mg/kg of body weight for oral administration.
Claim 7
Independent Claim
36 words
A method for treating premenopausal woman experiencing osteoporosis, the method comprising administering to a premenopausal woman an effective amount of clomiphene or its citrate salt to treat osteoporosis, either alone or in admixture with a diluent.
Claim 8
Independent Claim
36 words
A method for treating premenopausal woman experiencing osteoporosis, the method comprising administering to a premenopausal woman an effective amount of clomiphene or its citrate salt to treat osteoporosis, either alone or in admixture with a diluent.
Claim 9
Dependent Claim
15 words
A method according to claim 6, wherein clomiphene is in the form of clomiphene citrate.
Claim 10
Dependent Claim
12 words
A method according to claim 6, wherein said clomiphene is administered daily.
Claim 11
Dependent Claim
36 words
A method according to claim 8, wherein the clomiphene is administered in an amount of 0.01 to 10 mg/kg of body weight for intravenous administration and 0.05 to 20 mg/kg of body weight for oral administration.
Claim 12
Dependent Claim
36 words
A method according to claim 8, wherein the clomiphene is administered in an amount of 0.05 to 5 mg/kg of body weight for intravenous administration and 0.5 to 5 mg/kg of body weight for oral administration.
Claim 13
Independent Claim
44 words
A method of increasing bone mass or preventing bone loss in premenopausal woman comprising administering to a premenopausal woman an effective amount of clomiphene or its citrate salt to increase bone mass or prevent bone loss, either alone or in admixture with a diluent.
Claim 14
Independent Claim
44 words
A method of increasing bone mass or preventing bone loss in premenopausal woman comprising administering to a premenopausal woman an effective amount of clomiphene or its citrate salt to increase bone mass or prevent bone loss, either alone or in admixture with a diluent.
Claim 15
Dependent Claim
16 words
A method according to claim 11, wherein said clomiphene is in the form of clomiphene citrate.
Claim 16
Dependent Claim
12 words
A method according to claim 11, wherein said clomiphene is administered daily.
Claim 17
Dependent Claim
36 words
A method according to claim 13, wherein the clomiphene is administered in an amount of 0.01 to 10 mg/kg of body weight for intravenous administration and 0.05 to 20 mg/kg of body weight for oral administration.
Claim 18
Dependent Claim
36 words
A method according to claim 13, wherein the clomiphene is administered in an amount of 0.05 to 5 mg/kg of body weight for intravenous administration and 0.5 to 5 mg/kg of body weight for oral administration.
References Cited (Backward Citations)
GB1146405A
Cited
US4729999A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-12 | 1994-05-14 | 1994-11-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-12 | 1998-05-14 | 1998-11-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-12 | 2002-05-14 | 2002-11-13 | $7700.00 | Window Closed / Lapsed |