US4968539A
Expired / Lapsed
US
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Liquid crystal membrane
Assignee: Lion Corp
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Filing: 1988-11-30
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Granted: 1990-11-06
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Expires: 2008-11-30
Abstract
Abstract A polymer membrane for delivering a drug is provided. The membrane is capable of regulating the delivery of the drug and comprises (A) a porous hydrophobic polymer membrane having a pore diameter of not larger than 3 μm and a porosity of 10 to 90% which is immobilized with (B) a specific liquid crystal-forming compound having a gel/liquid crystal transition temperature in the range of 25° to 45° C.
Inventors
- 👤 Takao Aoyagi
- 👤 Shuji Sato
- 👤 Minako Yasu
- 👤 Iwao Nozawa
- 👤 Yousuke Suzuki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 10:35
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/009; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; C; C09; C09K; C09K19/00; C09K19/04; C09K19/38; C09K2323/00; C09K2323/05; Y; Y10; Y10S; Y10S428/00; Y10S428/913
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
224 words
A membrane for delivering a drug comprising: (A) a porous hydrophobic polymer membrane having a pore diameter of not larger than 3 μm and a porosity of 10 to 90% which is immobilized with; (B) a liquid crystal-forming compound having a gel/liquid crystal transition temperature in the range of 25 to 45° C. which is represented by the following general formula (I): ##STR2## wherein R 1 , R 2 and R 3 each represent a hydrogen or an alkyl group having 1 to 6 carbon atoms, R 4 , R 5 and R 6 each represent a hydrogen atom, an alkyl group having 6 to 30 carbon atoms or a group of the formula: --COR 9 , --COR 10 or --COR 11 wherein R 9 to R 11 are each a hydrogen or an alkyl group having 6 to 30 carbon atoms with the proviso that at least one or R 4 to R 6 has at least 6 carbon atoms, a, b, and c each represent a number from 0 to 20, n represents a number of 0 or 1, wherein the weight ratio of the liquid crystal forming compound (B) to the hydrophobic polymer membrane (A) is 98/2 to 5/95 and the amount of crystal-forming compound (B) is 1 to 3 times the amount of the porosity of the polymer membrane (A).
Claim 2
Dependent Claim
224 words
A membrane for delivering a drug comprising: (A) a porous hydrophobic polymer membrane having a pore diameter of not larger than 3 μm and a porosity of 10 to 90% which is immobilized with; (B) a liquid crystal-forming compound having a gel/liquid crystal transition temperature in the range of 25 to 45° C. which is represented by the following general formula (I): ##STR2## wherein R 1 , R 2 and R 3 each represent a hydrogen or an alkyl group having 1 to 6 carbon atoms, R 4 , R 5 and R 6 each represent a hydrogen atom, an alkyl group having 6 to 30 carbon atoms or a group of the formula: --COR 9 , --COR 10 or --COR 11 wherein R 9 to R 11 are each a hydrogen or an alkyl group having 6 to 30 carbon atoms with the proviso that at least one or R 4 to R 6 has at least 6 carbon atoms, a, b, and c each represent a number from 0 to 20, n represents a number of 0 or 1, wherein the weight ratio of the liquid crystal forming compound (B) to the hydrophobic polymer membrane (A) is 98/2 to 5/95 and the amount of crystal-forming compound (B) is 1 to 3 times the amount of the porosity of the polymer membrane (A).
Claim 3
Dependent Claim
73 words
The membrane for delivering a drug according to claim 1, wherein the polymer membrane is made of a substance selected from the group consisting of polyhexafluoropropylene, polytetrafluoroethylene, polytrifluoroethylene, polyvinylidene fluoride, polyvinyl fluoride, polyethylene, polytrifluorochloroethylene, polystyrene, polyurethane, polypropylene, polyvinyl chloride, polyvinylidene chloride, polyethylene terephthalate, nylon, polydimethylsiloxane, polycarbonates cellulose acetate, polyethylene vinylacetate, polyethylene vinyl alcohol, polymethyl (meth)acrylate, polyethyl (meth)acrylate, polybutyl (meth)acrylate, polyhexyl (meth)acrylate, polyoctyl (meth)acrylate, polylauryl (meth)acrylate, polystearyl (meth)acrylate, polybutadiene, polybutene, polyisoprene and natural rubber.
Claim 4
Dependent Claim
75 words
The membrane for delivering a drug according to claim 1, wherein the liquid crystal-forming compound is that of the formula (I) wherein R 1 to R 3 each represent a hydrogen or an alkyl group having 2 or 3 carbon atoms, R 4 to R 6 and R 9 to R 11 each represent an alkyl group having 12 to 18 carbon atoms and the total of a, b and c is 0 to 60.
Claim 5
Dependent Claim
31 words
The membrane for delivering a drug according to claim 1, wherein the liquid crystal-forming compound is immobilized to the membrane by absorbing it from a solution containing the liquid crystal-forming compound.
Claim 6
Dependent Claim
26 words
The membrane for delivering a drug according to claim 1, wherein the liquid crystal-forming compound is immobilized to the membrane by sandwiching it between the membranes.
Claim 7
Dependent Claim
17 words
The membrane for delivering a drug according to claim 1, which is combined with a heating member.
References Cited (Backward Citations)
US4692336A
Cited
US4513034A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-11-05 | 1994-05-07 | 1994-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-05 | 1998-05-07 | 1998-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-05 | 2002-05-07 | 2002-11-06 | $7700.00 | Window Closed / Lapsed |