US4968505A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Long-acting diclofenac sodium preparation
Assignee: SSP Co Ltd
•
Filing: 1989-05-17
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Granted: 1990-11-06
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Expires: 2009-05-17
Abstract
Abstract A long-acting diclofenac sodium preparation is disclosed. The preparation comprises a sustained-release diclofenac sodium component which is prepared by coating a sustained-release coat onto a pharmaceutical composition comprising diclofenac sodium and an organic acid. It can decrease the maximum blood concentration of diclofenac by suppressing and controlling the rate of release of diclofenac sodium and maintain the blood concentration of diclofenac constant for a considerably long period of time. The risk of side-effect occurrences is reduced and patients is released from frequent administration of the medicine.
Inventors
- 👤 Minoru Okada
- 👤 Syuichi Kasai
- 👤 Akira Iwasa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 06:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/5042; A61K9/5047; A61K31/19; A61K31/195; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K9/5026; A61K9/5073; A61P; A61P29/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
40 words
A long-acting diclofenac sodium preparation comprising a sustained-release diclofenac sodium component which is prepared by coating a sustained-release coat onto a pharmaceutical composition comprising 100 parts by weight of diclofenac sodium and 2-50 parts by weight of an organic acid.
Claim 2
Dependent Claim
40 words
A long-acting diclofenac sodium preparation comprising a sustained-release diclofenac sodium component which is prepared by coating a sustained-release coat onto a pharmaceutical composition comprising 100 parts by weight of diclofenac sodium and 2-50 parts by weight of an organic acid.
Claim 3
Dependent Claim
39 words
A long-acting diclofenac sodium preparation comprising: (i) a sustained-release diclofenac sodium component and (ii) a rapid-release diclofenac sodium component in an amount of 10-50% by weight as diclofenac sodium against the total amount of diclofenac sodium in the preparation.
Claim 4
Dependent Claim
39 words
A long-acting diclofenac sodium preparation comprising: (i) a sustained-release diclofenac sodium component and (ii) a rapid-release diclofenac sodium component in an amount of 10-50% by weight as diclofenac sodium against the total amount of diclofenac sodium in the preparation.
Claim 5
Dependent Claim
34 words
A long-acting diclofenac sodium preparation according to claim 1, wherein said sustained-release coat comprises an intestinally soluble polymer which is soluble in water at an acidity level in the range of about pH 5.5-7.
Claim 6
Dependent Claim
31 words
A long-acting diclofenac sodium preparation according to claim 3, wherein said sustained-release coat comprises an intestinally soluble polymer which is soluble in water at an acidity level of about pH 7.
Claim 7
Dependent Claim
18 words
A long-acting diclofenac sodium preparation according to claim 1, wherein said sustained-release coat comprises a water insoluble polymer.
Claim 8
Dependent Claim
34 words
A long-acting diclofenac sodium preparation according to claim 1, wherein said sustained-release coat comprises 1 part by weight of ethylcellulose, 0.2-0.5 part by weight of polyvinyl pyrrolidone, and 0.01-1.5 parts by weight of talc.
Claim 9
Dependent Claim
28 words
A long-acting diclofenac sodium preparation according to claim 1, wherein the amount of said sustained-release coat on the pharmaceutical composition is 1-80% by weight of said pharmaceutical composition.
Claim 10
Dependent Claim
28 words
A long-acting diclofenac sodium preparation according to claim 1, wherein the amount of said sustained-release coat on the pharmaceutical composition is 1-80% by weight of said pharmaceutical composition.
Claim 11
Dependent Claim
28 words
A long-acting diclofenac sodium preparation according to claim 3, wherein the amount of said sustained-release coat on the pharmaceutical composition is 1-80% by weight of said pharmaceutical composition.
Claim 12
Dependent Claim
28 words
A long-acting diclofenac sodium preparation according to claim 4, wherein the amount of said sustained-release coat on the pharmaceutical composition is 1-80% by weight of said pharmaceutical composition.
Claim 13
Dependent Claim
28 words
A long-acting diclofenac sodium preparation according to claim 5, wherein the amount of said sustained-release coat on the pharmaceutical composition is 1-80% by weight of said pharmaceutical composition.
Claim 14
Dependent Claim
28 words
A long-acting diclofenac sodium preparation according to claim 6, wherein the amount of said sustained-release coat on the pharmaceutical composition is 1-80% by weight of said pharmaceutical composition.
Claim 15
Dependent Claim
23 words
A long-acting diclofenac sodium preparation according to claim 2, wherein the sustained-release diclofenac sodium component and the rapid-release diclofenac sodium component are mixed.
Claim 16
Dependent Claim
24 words
A long-acting diclofenac sodium preparation according to claim 2, wherein the sustained-release diclofenac sodium component and the rapid-release diclofenac sodium component form separate layers.
References Cited (Backward Citations)
US4726951A
Cited
US4814183A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-05 | 1994-05-07 | 1994-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-05 | 1998-05-07 | 1998-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-05 | 2002-05-07 | 2002-11-06 | $7700.00 | Window Closed / Lapsed |