US4965200A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs
Assignee: Merck and Co Inc
•
Filing: 1989-06-23
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Granted: 1990-10-23
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Expires: 2009-06-23
Abstract
Abstract A biotransformation for the formation of a 3-keto-5-hydroxy simvastation analog (I) or a 8-acyloxy derivative thereof is disclosed. ##STR1##
Inventors
- 👤 Shieh-Shung J. Chen
- 👤 Byron H. Arison
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:19
CPC Classifications
C; C07; C07C; C07C69/00; C07C69/66; C07C69/73; C07C69/738; A; A61; A61P; A61P3/00; A61P3/06; A61P43/00; C07D; C07D309/00; C07D309/16; C07D309/28; C07D309/30; C12; C12P; C12P17/00; C12P17/02; C12P17/06; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
59 words
A process for the preparation of a compound represented by the formulae (I) ##STR15## which comprises culturing a microorganism Streptomyces sp. (MA6578) (ATCC 53898) in a nutrient medium containing assimilable sources of nitrogen and carbon and the sodium salt (II): ##STR16## under aerobic conditions until a substantial amount of the compound is produced and isolating the compound so produced.
Claim 2
Dependent Claim
59 words
A process for the preparation of a compound represented by the formulae (I) ##STR15## which comprises culturing a microorganism Streptomyces sp. (MA6578) (ATCC 53898) in a nutrient medium containing assimilable sources of nitrogen and carbon and the sodium salt (II): ##STR16## under aerobic conditions until a substantial amount of the compound is produced and isolating the compound so produced.
Claim 3
Dependent Claim
12 words
A process of claim 1 in which ##STR17## is 2-methylbutyryl or 2,2-dimethylbutyryl.
Claim 4
Dependent Claim
10 words
A process of claim 2 in which ##STR18## is 2,2-dimethylbutyryl.
Claim 5
Dependent Claim
10 words
A process of claim 2 in which ##STR19## is 2-methylbutyryl.
References Cited (Backward Citations)
GB2075013A
Cited
US4448979A
Cited
US4517373A
Cited
US4537859A
Cited
JPS59186972A
Cited
US4921974A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-22 | 1994-04-23 | 1994-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-22 | 1998-04-23 | 1998-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-22 | 2002-04-23 | 2002-10-23 | $7700.00 | Window Closed / Lapsed |