US4962197A
Expired / Lapsed
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Photo-inactivation of cancer cells
Assignee: Harvard University
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Filing: 1988-02-12
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Granted: 1990-10-09
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Expires: 2008-02-12
Abstract
Abstract A compound having the formula <IMAGE> (1) in which X is O, S, or Se; each R1, R2, and R3, independently, is H, a lower alkyl, or aralkyl; A is a saturated or unsaturated ring; and each Z1, Z2, Z3, Z4, Z5, Z6, Z7, or Z8, independently, is H or a halogen, provided that when X is O, at least one group Z is a halogen; when either Z2 or Z3 is a halogen, at least one of R2 or R3 is H; and when both Z2 and Z3 are halogens, both R2 and R3 are H; or a pharmaceutically acceptable salt thereof. The compounds are useful for photo-inactivation of cancer cells.
Inventors
- 👤 James W. Foley
- 👤 Louis Cincotta
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 12:04
CPC Classifications
C; C07; C07D; C07D279/00; C07D279/10; C07D279/14; C07D279/36; A; A61; A61K; A61K41/00; A61K41/0057; C07D265/00; C07D265/28; C07D265/34; C07D265/38
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
72 words
A compound having the formula ##STR15## wherein X is O, S, or Se; each R 1 , R 2 , and R 3 , independently, is H, lower alkyl, or aralkyl; ring A is a saturated or unsaturated ring; and each Z 1 , Z 2 , Z 3 , Z 4 , Z 5 , Z 6 , Z 7 , and Z 8 , independently, is H or a halogen,
Claim 2
Dependent Claim
72 words
A compound having the formula ##STR15## wherein X is O, S, or Se; each R 1 , R 2 , and R 3 , independently, is H, lower alkyl, or aralkyl; ring A is a saturated or unsaturated ring; and each Z 1 , Z 2 , Z 3 , Z 4 , Z 5 , Z 6 , Z 7 , and Z 8 , independently, is H or a halogen,
Claim 3
Dependent Claim
59 words
provided that when X is 0, at least one group Z is a halogen; when either Z 2 or Z 3 is a halogen, at least one of R 2 or R 3 is H; and when both Z 2 and Z 3 are halogens, both R 2 and R 3 are H; or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
59 words
provided that when X is 0, at least one group Z is a halogen; when either Z 2 or Z 3 is a halogen, at least one of R 2 or R 3 is H; and when both Z 2 and Z 3 are halogens, both R 2 and R 3 are H; or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
21 words
The compound of claim 1 wherein the pka of said N 2 is between 5 and 11, inclusive, in aqueous solution.
Claim 6
Dependent Claim
51 words
The compound of claim 1 wherein X is O; R 1 is H; R 2 is H; R 3 is ethyl; Z 1 and Z 2 are Br; ring A is unsaturated; and Z 3 -Z 8 are H, said compound having the formula ##STR16## or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
44 words
The compound of claim 1 wherein X is O; R 1 is H; R 2 and R 3 are ethyl; A is an unsaturated ring; and Z 2 -Z 8 are H, said compound having the formula ##STR17## or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
52 words
The compound of claim 1 wherein X is O; R 1 is H; R 2 is H; R 3 is ethyl; Z 1 and Z 2 are I; ring A is an unsaturated ring: and Z 3-Z 8 are H, said compound having the formula ##STR18## or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
52 words
The compound of claim 1 wherein X is O; R 1 is H; R 2 and R 3 are ethyl; ring A is unsaturated; Z 6 is I; and Z 1 -Z 5 and Z 7 -Z 8 are H, said compound having the formula ##STR19## or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
46 words
The compound of claim 1 wherein X is O; R 1 is H; R 2 and R 3 are ethyl; Z is Br; ring A is unsaturated; and Z 2 -Z 8 are H, said compound having the formula ##STR20## or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
55 words
The compound of claim 1 wherein X is O; R 1 is H; R 2 and R 3 are ethyl; Z 1 and R 6 are I; ring A is unsaturated; and Z 2 -Z 5 an Z 7 -Z 8 are H, said compound having the formula ##STR21## or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
43 words
The compound of claim 1 wherein X is S; R 1 is H; R 2 and R 3 are ethyl; ring A is unsaturated; and Z 1 -Z 8 are H. said compound having the formula ##STR22## or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
47 words
The compound of claim 1 wherein X is S; R 1 is H; R 2 and R 3 are ethyl; ring A is unsaturated; Z 1 is I; and Z 2 -Z 8 are H, said compound having the formula ##STR23## or a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
43 words
The compound of claim 1 wherein X is S; R 1 is benzyl; R 2 and R 3 are ethyl; ring A is unsaturated; and Z 1 -Z 8 are H, said compound having the formula ##STR24## or a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
43 words
The compound of claim 1 wherein X is S; R 1 is H; R 2 and R 3 are ethyl; ring A is saturated; and Z 1 -Z 8 are H, said compound having the formula ##STR25## or a pharmaceutically acceptable salt thereof.
Claim 16
Dependent Claim
47 words
The compound of claim 1 wherein X is S; R 1 is H; R 2 and R 3 are ethyl; Z 1 is I; ring A is saturated; and Z 2 -Z 8 are H, said compound having the formula ##STR26## or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-08 | 1994-04-09 | 1994-10-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-08 | 1998-04-09 | 1998-10-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-08 | 2002-04-09 | 2002-10-09 | $7700.00 | Window Closed / Lapsed |