Patent US3129323A successfully refreshed from Google Patents.
US4960467A
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Dermal substance collection device
Assignee: United States Department of the Army
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Filing: 1988-12-12
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Granted: 1990-10-02
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Expires: 2008-12-12
Abstract
Abstract A dermal substance collection device (DSCD) is described which provides means for the non-invasive, instantaneous and continuous monitoring of chemical substances which are present in a detectable amount in either or both interstitial fluid or sweat or which are on or in the skin. The transdermal substance collection device of this invention is comprised of three essential components: (1) a substance binding reservoir, wettable by (2) a liquid transfer medium which allows for liquid bridge transfer of a soluble substance from the skin surface to the binding reservoir by virtue of its wettability by the liquid, and (3) an occlusive cover.
Inventors
- 👤 Carl C. Peck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:10
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; A; A61; A61B; A61B10/00; A61B10/0045; A61B10/0064; A61B2010/0009
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
99 words
A gelled composition for the collection of a chemical substance from a dermal surface, said gelled composition consisting essentially of: (a) A binding reservoir material, having a particle size in the colloid range, for binding with said dermal substance to prevent back transfer loss of said dermal substance from said binding reservoir to the dermal surface; and (b) A liquid bridge transfer medium which comprises an aqueous gel that allows the instantaneous and continuous transfer of said dermal substance from the dermal surface to said binding reservoir material being maintained in a wet-state by said liquid bridge transfer medium.
Claim 2
Dependent Claim
99 words
A gelled composition for the collection of a chemical substance from a dermal surface, said gelled composition consisting essentially of: (a) A binding reservoir material, having a particle size in the colloid range, for binding with said dermal substance to prevent back transfer loss of said dermal substance from said binding reservoir to the dermal surface; and (b) A liquid bridge transfer medium which comprises an aqueous gel that allows the instantaneous and continuous transfer of said dermal substance from the dermal surface to said binding reservoir material being maintained in a wet-state by said liquid bridge transfer medium.
Claim 3
Dependent Claim
19 words
A composition according to claim 1 wherein said binding reservoir material is dispersed in said liquid bridge transfer medium.
Claim 4
Dependent Claim
14 words
A composition according to claim 2 wherein said binding reservoir material is activated charcoal.
Claim 5
Dependent Claim
15 words
A composition according to claim 1 wherein said aqueous gel includes an osmotically active substance.
Claim 6
Dependent Claim
15 words
A composition according to claim 1 wherein said aqueous gel comprises an agarose gelling agent.
Claim 7
Dependent Claim
17 words
A composition according to claim 1 wherein said aqueous gel comprises a polyvinyl alcohol polymer gelling agent.
Claim 8
Dependent Claim
15 words
A composition according to claim 1 wherein said aqueous gel includes a penetration enhancing agent.
Claim 9
Dependent Claim
23 words
A composition according to claim 7 wherein the penetration enhancing agent is selected from the group consisting of n,n-diethyl-m-toluamide, 1-dodecylazacycloheptan-2-one, and dimethyl sulfoxide.
Claim 10
Dependent Claim
23 words
A composition according to claim 4 wherein said aqueous gel consists essentially of an osmotically active aqueous solution and an agarose gelling agent.
Claim 11
Dependent Claim
26 words
A composition according to claim 9 wherein said osmotically active aqueous solution contains sodium chloride present in an amount up to saturation of said aqueous gel.
Claim 12
Dependent Claim
39 words
A composition according to claim 10 wherein the amount of agarose is 0.5 to 30% by weight of the aqueous sodium chloride solution and the amount of activated charcoal is 0.5 to 30% by weight of the aqueous gel.
Claim 13
Dependent Claim
34 words
A composition according to claim 11 wherein the amount of agarose is about 3 weight-percent of the sodium chloride solution and the amount of activated charcoal is about 5 weight-percent of the aqueous gel.
Claim 14
Dependent Claim
28 words
A composition according to claim 1 wherein said binding reservoir is selected from the group consisting of activated charcoal, ion-exchange resin, immobilized antibody, silica, zeolite and molecular sieve.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-01 | 1994-04-02 | 1994-10-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-01 | 1998-04-02 | 1998-10-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-01 | 2002-04-02 | 2002-10-02 | $7700.00 | Window Closed / Lapsed |