US4960415A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device for inserting in wounds and wound cavities
Assignee: Merck Patent GmbH
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Filing: 1988-11-18
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Granted: 1990-10-02
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Expires: 2008-11-18
Abstract
Abstract A device for inserting in wounds and wound cavities is described consisting of a container containing a pharmaceutical active substance, the walls of this container consisting at least partly of a membrane, preferably a semi-permeable membrane, which allows the active substance to escape into the wound area. The container is, more preferably, a dialysis tube. In order to drain off wound secretions, the container containing the pharmaceutically active substance, particularly taurolidine, is conveniently connected to a drainage tube. Preferably, a drainage tube is used in which the end which leads into the wound is split into filaments.
Inventors
- 👤 Johannes Reinmuller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:02
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L31/00; A61L31/14; A61L31/16; A61M; A61M27/00; A61M37/00; A61L2300/00; A61L2300/20; A61L2300/204; A61L2300/40; A61L2300/404; A61L2300/60; A61L2300/64
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
143 words
A device for inserting in wounds and wound cavities, comprising a container containing a pharmaceutically active solid substance, said container having walls formed, at least partially, of a membrane which allows the active substance to escape into the wound area, said pharmaceutically active substance having a low water solubility and being in the form of particles, said membrane comprising pores which are small enough to retain the particles within but do not restrict ingress of external body fluids, wherein the release rate of the substance into the external body fluids is limited largely by said water solubility; and a tubular wound drainage device connected to said container for draining away wound secretions from wounds and wound cavities wherein the tubular wound drainage device has an end for insertion in the body and said end is split into several filaments to facilitate wound drainage.
Claim 2
Independent Claim
143 words
A device for inserting in wounds and wound cavities, comprising a container containing a pharmaceutically active solid substance, said container having walls formed, at least partially, of a membrane which allows the active substance to escape into the wound area, said pharmaceutically active substance having a low water solubility and being in the form of particles, said membrane comprising pores which are small enough to retain the particles within but do not restrict ingress of external body fluids, wherein the release rate of the substance into the external body fluids is limited largely by said water solubility; and a tubular wound drainage device connected to said container for draining away wound secretions from wounds and wound cavities wherein the tubular wound drainage device has an end for insertion in the body and said end is split into several filaments to facilitate wound drainage.
Claim 3
Dependent Claim
13 words
The device of claim 1 in which the membrane is a semipermeable membrane.
Claim 4
Dependent Claim
16 words
The device of claim 2, wherein the container is a tube formed of the semi-permeable membrane.
Claim 5
Dependent Claim
12 words
The device of claim 3, wherein the container is a dialysis tube.
Claim 6
Dependent Claim
14 words
The device of claim 1 wherein the pharmaceutically active substance is in powder form.
Claim 7
Dependent Claim
18 words
The device of claim 1 wherein the pharmaceutically active substance is a substance with anti-bacterial and/or antitoxic activity.
Claim 8
Dependent Claim
12 words
The device of claim 1 wherein the pharmaceutically active substance is taurolidine.
Claim 9
Dependent Claim
14 words
The device of claim 1 wherein the container comprises a bundle of hollow fibers.
Claim 10
Dependent Claim
22 words
A method of treatment of wounds and wound cavities wherein a device as claimed in claim 1 is inserted in said wound.
Claim 11
Dependent Claim
16 words
The method of claim 9 wherein the wounds to be treated are osteitis or osteomyelitis cavities.
Claim 12
Dependent Claim
21 words
The device of claim 1 wherein the release of the substance into the external body fluids achieves a zero-order release rate.
Claim 13
Independent Claim
160 words
A device for inserting in wounds and wound cavities, comprising a container containing a solid precursor being able to form a pharmaceutically active substance by a chemical or enzymatic reaction, said container having walls formed, at least partially, of a membrane which allows said pharmaceutically active substance and/or said precursor to escape into the wound area, said precursor having a low water solubility and being in the form of particles, said membrane comprising pores which are small enough to retain the particles within but do not restrict ingress of external body fluids, wherein the release of the pharmaceutically active substance and/or said precursor into the external body fluids is limited largely by water solubility; and a tubular wound drainage device connected to said container for draining away wound secretions from wounds and wound cavities wherein the tubular wound drainage device has an end for insertion in the body and said end is split into several filaments to facilitate wound drainage.
Claim 14
Independent Claim
160 words
A device for inserting in wounds and wound cavities, comprising a container containing a solid precursor being able to form a pharmaceutically active substance by a chemical or enzymatic reaction, said container having walls formed, at least partially, of a membrane which allows said pharmaceutically active substance and/or said precursor to escape into the wound area, said precursor having a low water solubility and being in the form of particles, said membrane comprising pores which are small enough to retain the particles within but do not restrict ingress of external body fluids, wherein the release of the pharmaceutically active substance and/or said precursor into the external body fluids is limited largely by water solubility; and a tubular wound drainage device connected to said container for draining away wound secretions from wounds and wound cavities wherein the tubular wound drainage device has an end for insertion in the body and said end is split into several filaments to facilitate wound drainage.
Claim 15
Dependent Claim
14 words
The device of claim 12 wherein the precursor comprises living cells of connective tissue.
Claim 16
Dependent Claim
23 words
The device of claim 12 wherein the release of the substance and/or precursor into the external body fluids achieves a zero-order release rate.
References Cited (Backward Citations)
US3279996A
Cited
US3406691A
Cited
US4344431A
Cited
US3948254A
Cited
US3815608A
Cited
US4144317A
Cited
EP0048558A2
Cited
US4587268A
Cited
US4483688A
Cited
US4515593A
Cited
DE3217109A1
Cited
US4468216A
Cited
US4603152A
Cited
US4604391A
Cited
US4692153A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-01 | 1994-04-02 | 1994-10-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-01 | 1998-04-02 | 1998-10-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-01 | 2002-04-02 | 2002-10-02 | $7700.00 | Window Closed / Lapsed |