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US4958008A
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Process for crosslinking of collagen by introduction of azide groups as well as tissues and biomaterials obtained by use of the process
Assignee: Institut National de la Santé et de la Recherche Médicale
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Filing: 1988-07-07
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Granted: 1990-09-18
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Expires: 2008-07-07
Abstract
Abstract This process, which essentially comprises the following steps: esterification of the free acid groups of the collagen, transformation of the esterified groups into hydrazides groups, transformation of the hydrazide groups into azide groups by the action of nitrous acid, is characterized in that each step is separated by a rinsing in an aqueous salt solution, and in that the step of transformation of esterified groups into azide groups and the step of transformation of hydrazide groups into azide groups by the action of nitrous acid, are performed in the presence of salt.
Inventors
- 👤 Herve Petite
- 👤 Philippe Menasche
- 👤 Alain Huc
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:07
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61K; A61K35/00; A61K35/12; A61K35/32; A61K35/34; A61L27/14; A61L27/22; A61L27/24; C; C08; C08H; C08H1/00; C08H1/06; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2310/00; A61F2310/00005; A61F2310/00365; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
61 words
Process of crosslinking collagen by introducing azide groups which essentially comprises the following steps: esterification of the free acid groups of collagen, transformation of the esterified groups into hydrazides groups, transformation of the hydrazide groups into azide groups by the action of nitrous acid, and is characterized in that each step is separated by a rinsing in an aqueous salt solution.
Claim 2
Dependent Claim
61 words
Process of crosslinking collagen by introducing azide groups which essentially comprises the following steps: esterification of the free acid groups of collagen, transformation of the esterified groups into hydrazides groups, transformation of the hydrazide groups into azide groups by the action of nitrous acid, and is characterized in that each step is separated by a rinsing in an aqueous salt solution.
Claim 3
Dependent Claim
40 words
Process according to claim 1, wherein the step of transformation of esterified groups into azide groups and the step of transformation of hydrazide groups into azide groups by the action of nitrous acid, are performed in the presence of salt.
Claim 4
Dependent Claim
16 words
Process according to claims 1 and 2, wherein the salt is selected from alkaline metal salts.
Claim 5
Dependent Claim
18 words
Process according to claim 3, wherein the concentration of the aqueous salt solution is between 3 and 15%.
Claim 6
Dependent Claim
19 words
Process according to claim 4, wherein the crosslinking reaction by introduction of azide groups is performed on uncrosslinked collagens.
Claim 7
Dependent Claim
10 words
Application of the process of claim 1 for obtaining bioprotheses.
Claim 8
Dependent Claim
11 words
Application of the process according to claim 1 for obtaining biomaterials.
Claim 9
Dependent Claim
10 words
Application of the process of claim 2 for obtaining bioprotheses.
Claim 10
Dependent Claim
10 words
Application of the process of claim 3 for obtaining bioprotheses.
Claim 11
Dependent Claim
10 words
Application of the process of claim 4 for obtaining bioprotheses.
Claim 12
Dependent Claim
10 words
Application of the process of claim 5 for obtaining bioprotheses.
Claim 13
Dependent Claim
11 words
Application of the process according to claim 2 for obtaining biomaterials.
Claim 14
Dependent Claim
11 words
Application of the process according to claim 3 for obtaining biomaterials.
Claim 15
Dependent Claim
11 words
Application of the process according to claim 4 for obtaining biomaterials.
Claim 16
Dependent Claim
11 words
Application of the process according to claim 5 for obtaining biomaterials.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-09-17 | 1994-03-19 | 1994-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-17 | 1998-03-19 | 1998-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-09-17 | 2002-03-19 | 2002-09-18 | $7700.00 | Window Closed / Lapsed |