US4956181A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nitrate therapy for angina pectoris
Assignee: Eastman Kodak Co
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Filing: 1988-06-07
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Granted: 1990-09-11
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Expires: 2008-06-07
Abstract
Abstract Method and device for treating angina pectoris and preventing tolerance to nitrate drugs which takes into account the frequent need to provide the patient with relief from or prevention of pre-waking or early morning angina. The treatment comprises administering a daily unit dose of the nitrate before bedtime in a dosage form that (1) provides a washout period of 3 to 12 hours by sufficiently retarding delivery of the nitrate to the patient during the washout period so as to provide a rate of delivery of nitrate from the patch that is so low as to be insufficient to cause tolerance to said nitrate in said patient; (2) at the end of the washout period and at least 30 minutes before the patient expects to awaken, initiates an effective delivery period during which the dosage form provides an initial effective delivery rate sufficient to provide an antianginally effective concentration of nitrate in the blood stream of the patient; and (3) thereafter, during a ramp-up delivery period, delivers the nitrate at an increasing rate until a final delivery rate is achieved, which is from 125% to 1,000% of the initial effective delivery rate. At the end of the ramp-up period, delivery is exhausted or otherwise terminated. A new unit dose is administered at bedtime, and the cycle is repeated. A preferred transdermal patch for carrying out the treatment is provided.
Inventors
- 👤 Gerald W. Bayer
- 👤 Paul A. Diamantopoulos
- 👤 Hans W. Osterhoudt
- 👤 Paul F. Schmit
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:56
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
187 words
A transdermal patch for delivering a organic nitrate drug to a patient comprising, in combination: (i) an occlusive backing layer; (ii) a rupturable pod reservoir for containing an ointment composition; (iii) an ointment drug-containing composition disposed within said pod; said composition comprising said drug, a carrier for said drug and an activator liquid activator selected from the group consisting of ethanol, propanol, isopropanol, isobutanol, hexanol, octanol, decanol, dodecanol, ethylene glycol, propylene glycol, 1,3-propanediol, glycerin, ethyl, acetate, isopropyl myristate, lauryl myristate, decyl propionate, bis(2-ethylhexyl) phthalate, bis-(2-ethylhexyl) sebacate, di-n-butyl sebacate, diisopropyl adipate, mineral oil, bis(n-octyl) phthalate, cetyl alcohol, dibutyl phthalate, diethyl sebacate, ethyl lactate, ethyl phthalate, glycerol monostearate, glycerol distearate, glycerol tristearate, isopropyl palmitate, isopropyl stearate, N,N-bis(2-hydroxyethyl)dodecanamide, lauric myristic monoethanolamide, lauryl lactate, myristyl alcohol, n-decyl methylsulfoxide, N,N-dimethylacetamide, oleyl alcohol, phenylethyl alcohol, sodium lauryl sulfate, sodium stearate, stearyl alcohol, wood alcohols, 1,2,6-hexanetriol, water, and 2-amino-2-methyl-1-propanol; (iv) a barrier polymer film that is inherently resistant to the passage of said drug therethrough but becomes permeable to said drug by action of said activator liquid in said drug composition; and (v) a non-irritating pressure-sensitive adhesive layer that is permeable to said drug.
Claim 2
Dependent Claim
187 words
A transdermal patch for delivering a organic nitrate drug to a patient comprising, in combination: (i) an occlusive backing layer; (ii) a rupturable pod reservoir for containing an ointment composition; (iii) an ointment drug-containing composition disposed within said pod; said composition comprising said drug, a carrier for said drug and an activator liquid activator selected from the group consisting of ethanol, propanol, isopropanol, isobutanol, hexanol, octanol, decanol, dodecanol, ethylene glycol, propylene glycol, 1,3-propanediol, glycerin, ethyl, acetate, isopropyl myristate, lauryl myristate, decyl propionate, bis(2-ethylhexyl) phthalate, bis-(2-ethylhexyl) sebacate, di-n-butyl sebacate, diisopropyl adipate, mineral oil, bis(n-octyl) phthalate, cetyl alcohol, dibutyl phthalate, diethyl sebacate, ethyl lactate, ethyl phthalate, glycerol monostearate, glycerol distearate, glycerol tristearate, isopropyl palmitate, isopropyl stearate, N,N-bis(2-hydroxyethyl)dodecanamide, lauric myristic monoethanolamide, lauryl lactate, myristyl alcohol, n-decyl methylsulfoxide, N,N-dimethylacetamide, oleyl alcohol, phenylethyl alcohol, sodium lauryl sulfate, sodium stearate, stearyl alcohol, wood alcohols, 1,2,6-hexanetriol, water, and 2-amino-2-methyl-1-propanol; (iv) a barrier polymer film that is inherently resistant to the passage of said drug therethrough but becomes permeable to said drug by action of said activator liquid in said drug composition; and (v) a non-irritating pressure-sensitive adhesive layer that is permeable to said drug.
Claim 3
Dependent Claim
30 words
Means for preventing tolerance to an organic nitrate drug during long term therapy involving repeated administration of said drug, said means comprising a plurality of the patches of claim 1.
Claim 4
Dependent Claim
63 words
The patch of claim 1 wherein said barrier polymer is selected from the group consisting of rubbery vinyl copolymers, copolymers of styrene with ethylene and butylene or with butadiene; styrene-butadiene and styrene-isoprene copolymers; polymers of vinyl ethers; polymers of vinyl chloride, polymers of vinyl acetate; acrylic and acrylamide polymers; homopolymers and copolymers of ethylene, propylene, isoprene and butadiene, and low molecular weight polyethers.
Claim 5
Dependent Claim
56 words
The patch of claim 1 wherein said barrier polymer is selected from the group consisting of block copolymers of styrene and isoprene, block copolymers of styrene and butadiene, block copolymers of ethylene/styrene/ and butylene, polyisobutylene rubber, poly(vinyl isobutyl ether), poly(hexene-co-propylene), poly(vinyl acetate), copolymers of vinyl acetate with ethylene or with vinyl chloride, and cellulose acetate butyrate.
Claim 6
Dependent Claim
32 words
The patch of claim 1 wherein said barrier polymer is selected from the group consisting of poly(vinyl chloride-co-vinyl acetate), styrene-isoprene copolymers, poly(vinyl acetate), poly(vinyl isobutyl ether), poly(ethylene glycol) and cellulose acetate butyrate.
Claim 7
Dependent Claim
27 words
The patch of claim 5 wherein said activator is selected from n-decanol, n-octanol, dibutyl sebacate, bis(2-ethylhexyl) phthalate, isopropanol, glycerol, 1,3-propanediol, diisobutyl adipate, benzyl butyl phthalate and water.
Claim 8
Dependent Claim
18 words
The patch of claim 5 wherein said barrier polymer is selected from poly(vinyl chloride-co-vinyl acetate) and styrene-isoprene copolymers.
Claim 9
Dependent Claim
18 words
The patch of claim 5 wherein said barrier polymer is selected from poly(vinyl acetate) and cellulose acetate butyrate.
Claim 10
Dependent Claim
13 words
The patch of claim 5 wherein said barrier polymer is poly(vinyl isobutyl ether).
Claim 11
Dependent Claim
12 words
The patch of claim 5 wherein said barrier polymer is poly(ethylene glycol).
Claim 12
Dependent Claim
14 words
The patch of claim 4 wherein said barrier polymer is an ethylene-styrene-butylene block copolymer.
Claim 13
Dependent Claim
23 words
The patch of claim 7 wherein said activator is selected from the group consisting of dibutyl sebacate, bis(2-ethylhexyl) phthalate and benzyl butyl phthalate.
Claim 14
Dependent Claim
21 words
The patch of claim 8 wherein said activator is selected from the group consisting of diisobutyl adipate and benzyl butyl phthalate.
Claim 15
Dependent Claim
18 words
The patch of claim 9 wherein said activator is selected from the group consisting of n-decanol and n-octanol.
Claim 16
Dependent Claim
19 words
The patch of claim 10 wherein said activator is selected from the group consisting of glycerol, 1,3-propanediol and water.
Claim 17
Dependent Claim
13 words
The patch of claim 12 wherein said barrier polymer is poly(vinyl chloride-co-vinyl acetate).
Claim 18
Dependent Claim
29 words
The patch of claim 3 wherein said barrier polymer is selected from the styrene-isoprene and the styrene-butadiene copolymers and said activator is selected from dibutyl sebacate and bis(2-ethylhexyl) phthalate.
Claim 19
Dependent Claim
12 words
The patch of claim 13 wherein said barrier polymer is poly(vinyl acetate).
Claim 20
Dependent Claim
19 words
The patch of claim 4 wherein said barrier polymer is cellulose acetate butyrate and said activator is diisobutyl adipate.
Claim 21
Dependent Claim
15 words
The patch of claim 1 which further comprises a release liner overlaying the adhesive layer.
Claim 22
Dependent Claim
23 words
The patch of claim 1 wherein said occlusive backing layer comprises a laminate of an occlusive polymeric film and a heat sealable film.
Claim 23
Dependent Claim
23 words
The patch of claim 21 wherein said occlusive polymeric film is a polyester film and said heat sealable film is a polyolefin film.
Claim 24
Dependent Claim
20 words
The patch of claim 1 wherein the walls of said rupturable pod are impermeable to said drug-containing composition disposed therewithin.
Claim 25
Dependent Claim
25 words
The patch of claim 1 wherein said nitrate drug comprises an organic nitrate selected from nitroglycerine, isosorbide dinitrate, isosorbide-2-mononitrate, isosorbide-5-mononitrate, pentaerythritol tetranitrate, and erythrityl tetranitrate.
Claim 26
Dependent Claim
16 words
The patch of claim 11 wherein said activator is selected from isopropanol, isopropyl myristate and N,N-bis(2-hydroxyethyl)dodecanamide.
Claim 27
Dependent Claim
40 words
The patch of claim 1 wherein said activator is a plastisizer for said barrier polymer film, and said barrier polymer film becomes more permeable to the drug as it is plasticized by contact with said activator in said drug-containing composition.
Claim 28
Dependent Claim
38 words
The transdermal patch of claim 1 wherein said means for bringing the patch into drug delivery relationship with the patient comprises an adhesive peripheral boundary on the patch for adhering the patch to the skin of the patient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-09-10 | 1994-03-12 | 1994-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-10 | 1998-03-12 | 1998-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-09-10 | 2002-03-12 | 2002-09-11 | $7700.00 | Window Closed / Lapsed |