US4954351A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of producing standardized povidone iodine preparations and such preparations
Assignee: Euro Celtique SA
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Filing: 1988-09-22
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Granted: 1990-09-04
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Expires: 2008-09-22
Abstract
Abstract A pharmaceutical iodophor preparation having predictable microbicidal effectiveness and long duration of action comprising polyvinylpyrrolidone-iodine (PVPI), free iodine, a source of iodide ions and a source of iodate ions, the preparation having a ratio of available (titratable) iodine to iodide between 2:1 and 10:1, a pH between 5 and 6 and a free iodine concentration between 2 and 20 ppm, wherein the amount of iodate ion in the preparation is sufficient to maintain the free iodine concentration between 2 and 20 ppm for at least 12 months at 20° C.
Inventors
- 👤 Mortimer D. Sackler
- 👤 Ronald B. Miller
- 👤 Erwig O. Pinter
- 👤 Helmut E. W. Rackur
- 👤 Raymond R. Sackler
- 👤 Richard S. Sackler
- 👤 Alfred Halpern, deceased
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:00
CPC Classifications
A; A01; A01N; A01N59/00; A01N59/12; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
143 words
A method of producing a povidone iodine preparation having a predetermined concentration of free iodine which is immediately achieved and which remains constant and having predictable microbicidal effectiveness and long duration of action, the method comprising the steps of treating a mixture of povidone iodine and iodine ion in acidic solution with iodate ion to form an acidic solution containing between 2 and 20 ppm of free iodine and having an a available iodine to iodide ratio between 2:1 and 10:1, increasing the pH of said acidic solution to between 5 and 6, and adding additional iodate ion to the thus formed solution in an amount sufficient to maintain the amount of free iodine therein at a concentration of between 2 and 20 ppm, whereby the free iodine concentration is immediately achieved and remains stable for at least 12 months at 20° C.
Claim 2
Independent Claim
143 words
A method of producing a povidone iodine preparation having a predetermined concentration of free iodine which is immediately achieved and which remains constant and having predictable microbicidal effectiveness and long duration of action, the method comprising the steps of treating a mixture of povidone iodine and iodine ion in acidic solution with iodate ion to form an acidic solution containing between 2 and 20 ppm of free iodine and having an a available iodine to iodide ratio between 2:1 and 10:1, increasing the pH of said acidic solution to between 5 and 6, and adding additional iodate ion to the thus formed solution in an amount sufficient to maintain the amount of free iodine therein at a concentration of between 2 and 20 ppm, whereby the free iodine concentration is immediately achieved and remains stable for at least 12 months at 20° C.
Claim 3
Dependent Claim
26 words
A method according to claim 1 wherein the total amount of iodate ion added is between 0.22 wt % and 15 wt % of the preparation.
Claim 4
Dependent Claim
23 words
The method of claim 1 wherein the iodide ions are supplied by potassium iodide and the iodate ions are supplied by potassium iodate.
Claim 5
Dependent Claim
17 words
The method of claim 1 wherein the available iodine to iodide ratio is between 2:1 and 6:1.
Claim 6
Dependent Claim
17 words
The method of claim 1 wherein the available iodine to iodide ratio is between 2.1:1 and 3.6:1.
Claim 7
Dependent Claim
25 words
The method of claim 1 wherein the amount of iodate ion added is sufficient to maintain the concentration of free iodine at between 2-10 ppm.
Claim 8
Dependent Claim
23 words
The method of claim 1 wherein the amount of iodate ion is sufficient to maintain the free iodine concentration at between 2.5-3 ppm.
Claim 9
Dependent Claim
25 words
The method of claim 1 wherein the amount of iodate ion added is sufficient to maintain the concentration of free iodine at between 5-6 ppm.
Claim 10
Dependent Claim
17 words
The method of claim 1 wherein the pH of said acidic solution is increased to between 5.5-5.9.
References Cited (Backward Citations)
US4271149A
Cited
US4271149B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-09-03 | 1994-03-05 | 1994-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-03 | 1998-03-05 | 1998-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-09-03 | 2002-03-05 | 2002-09-04 | $7700.00 | Window Closed / Lapsed |