US4952396A
Expired / Lapsed
US
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Method of using phytic acid for inhibiting tumor growth
Assignee: Individual
•
Filing: 1988-06-10
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Granted: 1990-08-28
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Expires: 2008-06-10
Abstract
Abstract A method is provided for inhibiting tumor growth by administering to a subject an effective tumor-inhibiting amount of a compound selected from the group consisting of phytic acid, phytate salt, an isomer or hydrolysate of phytic acid or phytate salt, or a mixture of any combination thereof. The preferred method of administration is by oral dosages of about 2 to 4 grams/kilogram bodyweight per day.
Inventors
- 👤 Robert Sabin
- 👤 Raxit Jariwalla
- 👤 Stephen Lawson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/465; C; C12; C12Y; C12Y301/00; C12Y301/03; C12Y301/03008
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
51 words
A method of inhibiting tumor fibrosarcoma growth comprising the step of administering to a subject an effective tumor-inhibiting amount of a compound selected from the group consisting of phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof.
Claim 2
Independent Claim
51 words
A method of inhibiting tumor fibrosarcoma growth comprising the step of administering to a subject an effective tumor-inhibiting amount of a compound selected from the group consisting of phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof.
Claim 3
Dependent Claim
14 words
A method according to claim 1 wherein said phytate salt comprises its monopotassium salt.
Claim 4
Dependent Claim
33 words
A method according to claim 1 further comprising the step of coadministering to said subject a low calcium diet consisting of 100 to 600 mg calcium per day during treatment of said subject.
Claim 5
Dependent Claim
17 words
A method according to claim 1 wherein said phytic acid is absorbed into a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
26 words
A method according to claim 1 wherein said isomers of phytic acid or phytate salt comprise the hexakisphosphate myo-inositol, scyllo-inositol, D-chiro-inositol, L-chiro-inositol, neo-inositol and muco-inositol conformations.
Claim 7
Dependent Claim
20 words
A method according to claim 5 wherein said isomer of phytic acid or phytate salt is the hexakisphosphate myo-inositol conformation.
Claim 8
Dependent Claim
26 words
A method according to claim 1 wherein said hydrolysate of phytic acid or phytate salt comprises the pentakisphosphate, tetrakisphosphate, triphosphate, diphosphate, monophosphate or completely dephosphorylated hydrolysate.
Claim 9
Dependent Claim
18 words
A method according to claim 1 wherein said compound is administered orally in combination with a dephosphorylating enzyme.
Claim 10
Dependent Claim
18 words
A method according to claim 8 wherein said enzyme is 3-phytase, 6-phytase, acid phosphatase, or any combination thereof.
Claim 11
Dependent Claim
13 words
A method according to claim 9 wherein said enzyme is 3-phytase EC 3.1.3.8.
References Cited (Backward Citations)
US2834678A
Cited
US4154824A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-27 | 1994-02-26 | 1994-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-27 | 1998-02-26 | 1998-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-27 | 2002-02-26 | 2002-08-28 | $7700.00 | Window Closed / Lapsed |