US4948732A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Microbiological chiral reduction of carbonyl groups
Assignee: Merck Sharp & Dohme LLC
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Filing: 1989-09-26
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Granted: 1990-08-14
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Expires: 2009-09-26
Abstract
Abstract There is disclosed a novel microorganism Aspergillus niveus, ATCC 20922, and a process for chiral reduction of ketones using said microorganisms.
Inventors
- 👤 William Charney
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 06:14
CPC Classifications
C; C12; C12P; C12P13/00; C12P13/02; C12N; C12N1/00; C12N1/14; C12N1/145; C12P7/00; C12P7/02; C12R; C12R2001/00; C12R2001/645; C12R2001/66; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911; Y10S435/913
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
36 words
A process for chiral reduction of ketones to the corresponding hydroxy compound which comprises contacting said ketone with Aspergillus niveus in a culture medium and recovering said hydroxy compound that is formed in the culture medium.
Claim 2
Dependent Claim
36 words
A process for chiral reduction of ketones to the corresponding hydroxy compound which comprises contacting said ketone with Aspergillus niveus in a culture medium and recovering said hydroxy compound that is formed in the culture medium.
Claim 3
Dependent Claim
45 words
A process for preparing 5-{(R)-1-hydroxy-2-[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamide which comprises culturing the microorganism Aspergillus niveus (ATCC 20922) in a culture medium containing a ketone containing compound which is capable of undergoing chiral reduction of the ketone group and recovering the product that is formed in the culture medium.
Claim 4
Dependent Claim
45 words
A process for preparing 5-{(R)-1-hydroxy-2-[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamide which comprises culturing the microorganism Aspergillus niveus (ATCC 20922) in a culture medium containing a ketone containing compound which is capable of undergoing chiral reduction of the ketone group and recovering the product that is formed in the culture medium.
Claim 5
Dependent Claim
12 words
The process of claim 2 wherein the ketone compound is 5-{(R)-[(1-methyl-3-phenylpropyl)-amino]acetyl} salicylamide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-13 | 1994-02-12 | 1994-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-13 | 1998-02-12 | 1998-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-13 | 2002-02-12 | 2002-08-14 | $7700.00 | Window Closed / Lapsed |