Abstract PCT No. PCT/JP88/00483 Sec. 371 Date Jun. 9, 1988 Sec. 102(e) Date Jun. 9, 1988 PCT Filed May 23, 1988 PCT Pub. No. WO89/05635 PCT Pub. Date Jun. 29, 1989.Solid medicament forms, such as granules, beads, tablets, are first coated with a hot aqueous dispersion of a cellulose ether, which is soluble in cold water but insoluble in hot water, and then subjected to a wax treatment with heating to form a masking layer of the wax. Different from the coating film of a cellulose ether formed by using an aqueous or organic solution of the cellulose ether, the coating film formed by using the aqueous dispersion of the cellulose ether has a porous structure so that the amount of the wax deposited in the wax treatment is much larger than in the prior art methods to exhibit a high effect of masking the bitterness of the ingredient contained in the medicament form.
A method for the preparation of a coated solid medicament form which comprises the steps of: (a) coating a solid medicament form by using a coating liquid which is an aqueous dispersion of a powder of a cellulose ether, which is insoluble in hot water butsoluble in cold water, in hot water; and (b) subjecting the coated solid medicament form obtained in the step (a) to a heat treatment in the presence of a wax.
Claim 2
Independent Claim
75 words
A method for the preparation of a coated solid medicament form which comprises the steps of: (a) coating a solid medicament form by using a coating liquid which is an aqueous dispersion of a powder of a cellulose ether, which is insoluble in hot water butsoluble in cold water, in hot water; and (b) subjecting the coated solid medicament form obtained in the step (a) to a heat treatment in the presence of a wax.
Claim 3
Dependent Claim
49 words
The method for the preparation of a coated solid medicament form as claimed in claim 1 wherein the cellulose ether, which is insoluble in hot water but soluble in cold water is selected from the group consisting of hydroxypropyl methyl cellulose, methyl cellulose, hydroxypropyl cellulose and hydroxyethyl methyl cellulose.
Claim 4
Dependent Claim
47 words
The method for the preparation of a coated solid medicament form as claimed in claim 1 wherein the wax is selected from the group consisting of paraffin waxes, beeswaxes, higher alcohols, higher fatty acids, estes of higher fatty acids, fatty acid esters of glycerin and polyethylene glycols.
Claim 5
Dependent Claim
36 words
The method for the preparation of a coated solid medicament form as claimed in claim 1 wherein the aqueous dispersion of a powder of the cellulose ether contains from 5 to 30% by weight of solid.
Claim 6
Dependent Claim
31 words
The method for the preparation of a coated solid medicament form as claimed in claim 1 wherein the wax has a melting point in the range from 40° to 90° C.