US4946929A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bioerodible articles useful as implants and prostheses having predictable degradation rates
Assignee: Massachusetts Institute of Technology
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Filing: 1987-06-15
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Granted: 1990-08-07
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Expires: 2007-06-15
Abstract
Abstract A novel series of articles useful as implants and prostheses and methods for their preparation and use are provided which utilize polyanhydride polymeric matrices as a general class of materials. These articles are biocompatible, non-inflammatory and degrade predictably into non-toxic residues after introduction in-vivo. The articles may be formed in any desired dimensions and configuration and may take specific shape as vascular or skin grafts, as biodegradable sutures or as orthopedic appliances such as bone plates and the like.
Inventors
- 👤 Patricia D'Amore
- 👤 Kam W. Leong
- 👤 Robert S. Langer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:28
CPC Classifications
C; C08; C08G; C08G67/00; C08G67/04; A; A61; A61L; A61L17/00; A61L17/06; A61L17/10; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/58
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
115 words
A method of forming an implantable article and implantation in vivo comprising the steps of: forming an implantable article from a biocompatible, bioerodible, hydrophobic, purified polyanhydride composition of the formula: ##STR8## wherein R is an organic group and n is at least 2, said polyanhydride being characterized by biocompatibility that results in minimal tissue irritation when implanted in vasculated tissue and degrading by hydrolysis at predictable and constant rates into non-toxic residues after introduction in vivo; and locating said article in a subject at a preselected site, said article dimensions, configuration, and composition being selected to produce an implant having the required structure and physical properties to provide a desired function at the preselected site.
Claim 2
Independent Claim
115 words
A method of forming an implantable article and implantation in vivo comprising the steps of: forming an implantable article from a biocompatible, bioerodible, hydrophobic, purified polyanhydride composition of the formula: ##STR8## wherein R is an organic group and n is at least 2, said polyanhydride being characterized by biocompatibility that results in minimal tissue irritation when implanted in vasculated tissue and degrading by hydrolysis at predictable and constant rates into non-toxic residues after introduction in vivo; and locating said article in a subject at a preselected site, said article dimensions, configuration, and composition being selected to produce an implant having the required structure and physical properties to provide a desired function at the preselected site.
Claim 3
Dependent Claim
64 words
The method of claim 1 wherein said R group is selected from the group consisting of hydrocarbons of from 2 to 16 carbon atoms, ##STR9## wherein x is at least 2 and not greater than 16, ##STR10## wherein x is at least 1, ##STR11## wherein x is at least 1 and y is at least 1, ##STR12## wherein R' and R" are organic groups.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein said polyanhydride composition is implanted subcutaneously.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said polyanhydride composition is implanted intramuscularly.
Claim 6
Dependent Claim
17 words
The method of claim 1 wherein said polyanhyride composition is implanted on tissue as a skin equivalent.
Claim 7
Dependent Claim
27 words
The method of claim 1 further comprising forming said polyanhydride composition into a bone prosthesis and locating said bone prosthesis at the appropriate site in the subject.
Claim 8
Dependent Claim
20 words
The method of claim 1 further comprising incorporating substances enhancing repair of body tissues and organs into said polyanhydride composition.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-06 | 1994-02-05 | 1994-08-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-06 | 1998-02-05 | 1998-08-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-06 | 2002-02-05 | 2002-08-07 | $7700.00 | Window Closed / Lapsed |