US4944767A — Synthetic material apt to stably adsorb high quan…

Claim 1

Independent Claim 91 words

Synthetic material apt to stably adsorb high quantities of heparin, characterized in that said synthetic material consists of a polyurethane resin, cross-linked with copolymeric chains in correspondence of at least part of the urethane groups ##STR9## of said resin, as per the following general formula: ##STR10## wherein, PU--is a polyurethanic polymeric chain; R 1 is an alkyl or aralkyl, containing functional groups inert to isocyanates; R 2 is an alkylene; R 3 is an alkylene, arylene or other bivalent organic residue of a diisocyanate; and R n is a polyamidoaminic radical.

Claim 2

Dependent Claim 91 words

Synthetic material apt to stably adsorb high quantities of heparin, characterized in that said synthetic material consists of a polyurethane resin, cross-linked with copolymeric chains in correspondence of at least part of the urethane groups ##STR9## of said resin, as per the following general formula: ##STR10## wherein, PU--is a polyurethanic polymeric chain; R 1 is an alkyl or aralkyl, containing functional groups inert to isocyanates; R 2 is an alkylene; R 3 is an alkylene, arylene or other bivalent organic residue of a diisocyanate; and R n is a polyamidoaminic radical.

Claim 3

Dependent Claim 55 words

The synthetic material of claim 1, wherein the cross-linking copolymeric chains only the following general formula: ##STR11## and are obtained by reaction between a poly(amidoamine) of general formula: ##STR12## and a diisocyanate of general formula: O═C═N--R.sup.3 --N═C═O wherein R 1 , R 2 , R 3 and R n are as defined in claim 1.

Claim 4

Dependent Claim 27 words

The synthetic material of claim 1, wherein R n has the following general formula: ##STR13## wherein R 1 and R 2 are as defined in claim 1.

Claim 5

Dependent Claim 36 words

The synthetic material of claim 1 and n is at least one but low enough that the poly (amidoamine) precursor is soluble in an anhydrous organic solvent, wherein: R.sup.1 =--CH.sub.3, R.sup.2 =--(CH.sub.2).sub.4 --, R.sup.3 =--(CH.sub.2).sub.6 --.

Claim 6

Dependent Claim 47 words

The synthetic material of claim 2 wherein R n has the following formula: ##STR14## wherein R 1 and R 2 are as defined in claim 2 and n is at least one but low enough that the poly (amidoamine) precursor is soluble in an anhydrous organic solvent.

Claim 7

Dependent Claim 30 words

The synthetic material of claim 5, wherein R 1 is --CH 3 , R 2 is --(CH 2 ) 4 -- and R 3 is --(CH 2 ) 6 --.

Claim 8

Dependent Claim 30 words

The synthetic material of claim 3 wherein R 1 is --CH 3 , R 2 is --(CH 2 ) 4 -- and R 3 is --(CH 2 ) 6 --.

Claim 9

Dependent Claim 12 words

The synthetic material of claim 1 which has superficially adsorbed some heparin.

Claim 10

Dependent Claim 25 words

The method of using of the material of claim 8, for manufacturing prosthetic elements or other materials equipment designed to come in contact with blood.

Claim 11

Dependent Claim 118 words

Process for the production of a synthetic material apt to stably adsorb high quantities of heparin, characterized in that said process comprises the following steps: (a) Preparing a solution of poly(amidoamine) of general formula: ##STR15## wherein, R 1 is an alkyl or aralkyl, containing functional groups inert to isocyanates; R 2 is an alkylene; and R n is a polyamidoaminic radical, with a diisocyanate of general formula: O═C═N--R.sup.3 --N═C═O wherein R 3 is an alkylene, arylene or other bivalent organic residue of a diisocyanate, in a first anhydrous solvent; (b) Preparing a solution of a polyurethane in a second anhydrous solvent; (c) Thoroughly mixing the solutions obtained in (a) and (b); (d) Desiccating the solution obtained in (c).

Claim 12

Dependent Claim 118 words

Process for the production of a synthetic material apt to stably adsorb high quantities of heparin, characterized in that said process comprises the following steps: (a) Preparing a solution of poly(amidoamine) of general formula: ##STR15## wherein, R 1 is an alkyl or aralkyl, containing functional groups inert to isocyanates; R 2 is an alkylene; and R n is a polyamidoaminic radical, with a diisocyanate of general formula: O═C═N--R.sup.3 --N═C═O wherein R 3 is an alkylene, arylene or other bivalent organic residue of a diisocyanate, in a first anhydrous solvent; (b) Preparing a solution of a polyurethane in a second anhydrous solvent; (c) Thoroughly mixing the solutions obtained in (a) and (b); (d) Desiccating the solution obtained in (c).

Claim 13

Dependent Claim 68 words

The process of claim 10, wherein the product obtained at the end of step (d) is a polyurethanic resin, cross-linked with copolymeric chains in correspondence of at least part of the urethane groups ##STR16## of said resin, as per the following general formula: ##STR17## wherein, PU--is a polyurethanic polymeric chain, and R 1 , R 2 , R 3 and R n are as defined in claim 8.

Claim 14

Dependent Claim 47 words

The process of claim 10, wherein R n has the following general formula: ##STR18## wherein R 1 and R 2 are as defined in claim 8 and n is at least one but low enough that the poly (amidoamine) precursor is soluble in an anhydrous organic solvent.

Claim 15

Dependent Claim 14 words

The process of claim 10, wherein: R.sup.1 =--CH.sub.3, R.sup.2 =--(CH.sub.2).sub.4 --, R.sup.3 =--(CH.sub.2).sub.6 --.

Claim 16

Dependent Claim 15 words

The process of claim 10, wherein said first solvent comprises methylene chloride, chloroform or dimethylsulphoxide.

Claim 17

Dependent Claim 14 words

The process of claim 10, wherein said second solvent comprises dimethylformamide, dimethylacetamide, or hexamethylphosphoramide.

Claim 18

Dependent Claim 18 words

The process of claim 10, wherein the molar ratio between diisocyanate and poly(amidoamine) is between 0.75:1 and 5:1.

Claim 19

Dependent Claim 18 words

The process of claim 10, wherein the molar ratio between polyurethane and poly(amidoamine) is between 100:1 and 1:1.

Claim 20

Dependent Claim 26 words

The process of claim 10, further comprising the step of submitting the product obtained at the end of the step (d) to a superficial heparinization treatment.

Claim 21

Dependent Claim 47 words

The process of claim 11 wherein R n has the following general formula: ##STR19## wherein R 1 and R 2 as are defined in claim 9 and n is at least one but low enough that the poly (amidoamine) precursor is soluble in an anhydrous organic solvent.

Claim 22

Dependent Claim 29 words

The process of claim 19 wherein R 1 is --CH 3 , R 2 is --(CH 2 ) 4 -- and R 3 is --(CH 2 ) 6 --.

Claim 23

Dependent Claim 29 words

The process of claim 12 wherein R 1 is --CH 3 , R 2 is --(CH 2 ) 4 -- and R 3 is --(CH 2 ) 6 --.

Claim 24

Dependent Claim 109 words

In a prosthetic element or medical equipment designed to come in contact with blood the improvement comprising at least partially constructing it from a synthetic material which has superficially adsorbed some heparin and which comprises a polyurethane resin crosslinked with copolymeric chains in correspondence of at least part of the urethane groups ##STR20## of said resin, as per the following general formula: ##STR21## wherein PU--is a polyurethane polymeric chain; R 1 is an alkyl or aralkyl, containing no functional groups reactive with isocyanate; R 2 is an alkylene; R 3 is an alkylene, arylene or other bivalent organic residue of a diisocyanate; and R n is a polyamidoaminic radical.

Claim 25

Dependent Claim 109 words

In a prosthetic element or medical equipment designed to come in contact with blood the improvement comprising at least partially constructing it from a synthetic material which has superficially adsorbed some heparin and which comprises a polyurethane resin crosslinked with copolymeric chains in correspondence of at least part of the urethane groups ##STR20## of said resin, as per the following general formula: ##STR21## wherein PU--is a polyurethane polymeric chain; R 1 is an alkyl or aralkyl, containing no functional groups reactive with isocyanate; R 2 is an alkylene; R 3 is an alkylene, arylene or other bivalent organic residue of a diisocyanate; and R n is a polyamidoaminic radical.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1993-07-30	1994-01-29	1994-07-31	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1997-07-30	1998-01-29	1998-07-31	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2001-07-30	2002-01-29	2002-07-31	$7700.00	Window Closed / Lapsed

Synthetic material apt to stably adsorb high quantities of heparin, and process for the production thereof

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