Dispenser comprising displaceable matrix with solid state properties

Claim 2

A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in a part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) first means comprising a member selected from a solid and semisolid pharmaceutically acceptable carrier in the lumen for administering a beneficial agent to the animal environment of use, said means substantially maintaining its physical and chemical integrity while in the lumen of the dispenser; (c) a beneficial agent in the first means for administering a beneficial agent; (d) second means adjacent to the first means for occupying an increasing amount of space in the lumen for urging the first means comprising the beneficial agent from the dispenser; and (e) an opened mouth in the dispenser comprising a cross-sectional dimension substantially equal to the cross-sectional dimension of the lumen for displacing the first means substantially intact and unchanged and comprising the beneficial agent for administering the beneficial agent to the environment of use.

Claim 3

The dispenser for administering the beneficial agent formulation to an animal environment according to claim 1, wherein the means in the lumen for administering the beneficial agent comprises a cross-sectional dimension substantially equal to the internal cross-sectional dimension of the lumen.

Claim 4

The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the means in the lumen for administering the beneficial agent comprises a hydrophobic composition.

Claim 5

The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the means in the lumen for administering the beneficial agent comprises a hydrophilic composition that is a different composition than the means for occupying space.

Claim 6

The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the means in the lumen for administering the beneficial agent is urged through the mouth into the animal environment and bioerodes therein.

Claim 7

The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the means in the lumen for administering the beneficial agent is delivered from the dispenser and is hydrolyzed in the animal environment.

Claim 8

The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the means in the lumen for administering the beneficial agent is delivered from the dispenser and is solubilized in the animal environment.

Claim 9

The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the means in the lumen for administering the beneficial agent is urged from the dispenser and dissolved in the animal environment.

Claim 10

The dispenser form administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the means in the lumen for administering the beneficial agent disintegrates in the animal environment.

Claim 11

The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the means administers the beneficial agent by at least one process comprising diffusion, osmosis, osmotic bursting, solution leaching, solubilization, hydrolysis, enzymatic digestion, displacement and dissolution.

Claim 12

The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the animal environment of use is a ruminant.

Claim 13

The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the animal environment of use is a human.

Claim 14

A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) a carrier comprising a member selected from the group consisting of a pharmaceutically acceptable solid and semisolid carrier in the lumen for administering a beneficial agent to the animal environment of use, said carrier symmetrical with the axis of the lumen and substantially maintaining its physical and chemical integrity while in the lumen of the dispenser; (c) a beneficial agent in the carrier; (d) means adjacent to the carrier for occupying an increasing amount of space in the lumen for urging the carrier comprising the beneficial agent from the dispenser; (e) means in the lumen for maintaining the dispenser in the animal environment of use over time; and, (f) an opening in the wall of the dispenser comprising a cross-sectional dimension substantially equal to the cross-sectional dimension of the lumen for urging the carrier substantially intact and unchanged and comprising the beneficial agent for administering the beneficial agent to the environment of use.

Claim 15

A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) a carrier comprising a member selected from the group consisting of a pharmaceutically acceptable solid and semisolid carrier in the lumen for administering a beneficial agent to the animal environment of use, said carrier symmetrical with the axis of the lumen and substantially maintaining its physical and chemical integrity while in the lumen of the dispenser; (c) a beneficial agent in the carrier; (d) means adjacent to the carrier for occupying an increasing amount of space in the lumen for urging the carrier comprising the beneficial agent from the dispenser; (e) means in the lumen for maintaining the dispenser in the animal environment of use over time; and, (f) an opening in the wall of the dispenser comprising a cross-sectional dimension substantially equal to the cross-sectional dimension of the lumen for urging the carrier substantially intact and unchanged and comprising the beneficial agent for administering the beneficial agent to the environment of use.

Claim 16

A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a hollow body member comprising an internal lumen and provided with an opening substantially equivalent to the cross-section of the lumen for establishing communication with the lumen; (b) a pharmaceutically acceptable carrier comprising a member selected from the group consisting of a solid and semisolid carrier in the lumen for administering a beneficial agent to the animal environment of use, said carrier substantially keeping its integrity in the lumen; (c) a beneficial agent in the carrier; (d) means adjacent to the carrier for occupying an increasing amount of space in the lumen for pushing the carrier comprising the beneficial agent from the dispenser; (e) a wall that surrounds the hollow body member comprising at least in part a semipermeable composition that is permeable to the passage of fluid and substantially impermeable to the passage of a beneficial agent and, (f) an opening in the wall communicating with the lumen, which opening comprises a cross-section dimension corresponding to the cross-section of the carrier in the lumen for pushing the carrier intact from the lumen for administering the beneficial agent.

Claim 17

A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a hollow body member comprising an internal lumen and provided with an opening substantially equivalent to the cross-section of the lumen for establishing communication with the lumen; (b) a pharmaceutically acceptable carrier comprising a member selected from the group consisting of a solid and semisolid carrier in the lumen for administering a beneficial agent to the animal environment of use, said carrier substantially keeping its integrity in the lumen; (c) a beneficial agent in the carrier; (d) means adjacent to the carrier for occupying an increasing amount of space in the lumen for pushing the carrier comprising the beneficial agent from the dispenser; (e) a wall that surrounds the hollow body member comprising at least in part a semipermeable composition that is permeable to the passage of fluid and substantially impermeable to the passage of a beneficial agent and, (f) an opening in the wall communicating with the lumen, which opening comprises a cross-section dimension corresponding to the cross-section of the carrier in the lumen for pushing the carrier intact from the lumen for administering the beneficial agent.

Claim 18

A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a hollow body member having an internal lumen and provided with an opening substantially equivalent to the cross-section of the lumen for establishing communication with the lumen; (b) first means in the lumen for administering a beneficial agent to the animal environment of use, said means substantially keeping its integrity in the lumen and comprising a member selected from the group consisting of a solid and semisolid pharmaceutically acceptable carrier; (c) a beneficial agent in the first means; (d) second means adjacent to the first means for occupying an increasing volume in the lumen for displacing the first means from the dispenser; (e) third means in the lumen for maintaining the dispenser in the animal environment over time; (f) a wall that surrounds the hollow body member comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of the beneficial agent; and, (g) an opening in the wall communicating with the lumen, said opening comprising a cross-section substantially equivalent to the cross-section of the lumen for displacing the first means comprising the beneficial agent substantially intact and unchanged from the lumen for administering the beneficial agent to the animal environment.

Claim 19

A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a hollow body member having an internal lumen and provided with an opening substantially equivalent to the cross-section of the lumen for establishing communication with the lumen; (b) first means in the lumen for administering a beneficial agent to the animal environment of use, said means substantially keeping its integrity in the lumen and comprising a member selected from the group consisting of a solid and semisolid pharmaceutically acceptable carrier; (c) a beneficial agent in the first means; (d) second means adjacent to the first means for occupying an increasing volume in the lumen for displacing the first means from the dispenser; (e) third means in the lumen for maintaining the dispenser in the animal environment over time; (f) a wall that surrounds the hollow body member comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of the beneficial agent; and, (g) an opening in the wall communicating with the lumen, said opening comprising a cross-section substantially equivalent to the cross-section of the lumen for displacing the first means comprising the beneficial agent substantially intact and unchanged from the lumen for administering the beneficial agent to the animal environment.