Adaptive method for reducing motion and flow artifacts in NMR images

Claim 2

An NMR system, the combination comprising: means for generating a polarizing magnetic field; excitation means for generating an RF excitation magnetic field which produces transverse magnetization in nuclei subjected to the polarizing magnetic field; receiver means for sensing the NMR signal produced by the transverse magnetization and producing digitized in-phase (I) and quadrature (Q) samples of the NMR signal; first gradient means for generating a first magnetic field gradient to impart a first phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a first coordinate axis; second gradient means for generating a second magnetic field gradient to impart a second phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a second coordinate axis; pulse control means coupled to the excitation means, first and second gradient means, and receiver means, said pulse control means being operable to conduct a scan in which a series of pulse sequences are conducted in which the second magnetic field gradient is stepped through a series of discrete values and a corresponding series of NMR signals are sensed and digitized to form an NMR data set; and processor means for storing the NMR data set and for reconstructing an image array for a display from the stored NMR data set by: (a) Fourier transforming the NMR data set along one of its dimensions to create hybrid-space data arrays I' and Q'; (b) producing a correction data array using the data in the hybrid-space data arrays I' and Q' by calculating the magnitude of the transformed sampled NMR signals in the hybrid-space data arrays I' and Q' to produce a modulus array, and correlating each row of the modulus array to produce a corresponding shift value for the correction data array; (c) applying the data in the correction data array to the NMR data set to reduce motion effects; and (d) Fourier transforming the corrected NMR image data set to produce the image array.

Claim 3

The NMR system as recited in claim 1 in which a rollback correction data array is produced from the corresponding shift values in the correction data array and a rollover rate K R , and the rollback correction data array values are applied to correct the NMR image data set in step (c).

Claim 4

An NMR system, the combination comprising: means for generating a polarizing magnetic field; excitation means for generating an RF excitation magnetic field which produces transverse magnetization in nuclei subjected to the polarizing magnetic field; receiver means for sensing the NMR signal produced by the transverse magnetization and producing digitized in-phase (I) and quadrature (Q) samples of the NMR signal; first gradient means for generating a first magnetic field gradient to impart a first phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a first coordinate axis; second gradient means for generating a second magnetic field gradient to impart a second phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a second coordinate axis; pulse control means coupled to the excitation means, first and second gradient means, and receiver means, said pulse control means being operable to conduct a scan in which a series of pulse sequences are conducted in which the second magnetic field gradient is stepped through a series of discrete values and a corresponding series of NMR signals are sensed and digitized to form an NMR data set; and processor means for storing the NMR data set and for reconstructing an image array for a display from the stored NMR data set by: (a) Fourier transforming the NMR data set along one of its dimensions to create hybrid-space data arrays I' and Q'; (b) producing a correction data array using the data in the hybrid-space data arrays I' and Q' by calculating the phase of the transformed sampled NMR signals in the hybrid-space data arrays I' and Q' to produce a two-dimensional phase array, and determining the difference in phase between elements in a reference row of the phase array and elements in the same column of the phase array to produce the values for the correction data array; (c) applying the data in the correction data array to the NMR data set to reduce motion effects; and (d) Fourier transforming the corrected NMR image data set to produce the image array.

Claim 5

An NMR system, the combination comprising: means for generating a polarizing magnetic field; excitation means for generating an RF excitation magnetic field which produces transverse magnetization in nuclei subjected to the polarizing magnetic field; receiver means for sensing the NMR signal produced by the transverse magnetization and producing digitized in-phase (I) and quadrature (Q) samples of the NMR signal; first gradient means for generating a first magnetic field gradient to impart a first phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a first coordinate axis; second gradient means for generating a second magnetic field gradient to impart a second phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a second coordinate axis; pulse control means coupled to the excitation means, first and second gradient means, and receiver means, said pulse control means being operable to conduct a scan in which a series of pulse sequences are conducted in which the second magnetic field gradient is stepped through a series of discrete values and a corresponding series of NMR signals are sensed and digitized to form an NMR data set; and processor means for storing the NMR data set and for reconstructing an image array for a display from the stored NMR data set by: (a) Fourier transforming the NMR data set along one of its dimensions to create hybrid-space data arrays I' and Q'; (b) producing a correction data array using the data in the hybrid-space data arrays I' and Q' by calculating the phase of the transformed sampled NMR signals in the hybrid-space data arrays I' and Q' to produce a two-dimensional phase array, and determining the difference in phase between elements in a reference row of the phase array and elements in the same column of the phase array to produce the values for the correction data array; (c) applying the data in the correction data array to the NMR data set to reduce motion effects; and (d) Fourier transforming the corrected NMR image data set to produce the image array.

Claim 6

The NMR system as recited in claim 1 in which a second correction data array is produced by calculating the phase of the transformed sampled NMR signals in the hybrid-space data arrays I' and Q' to produce a two-dimensional phase array, and determining the phase difference between elements in a reference row of the phase array and elements in the same column of the phase array to produce the values for the second correction data array.

Claim 7

An NMR system, the combination comprising: means for generating a polarizing magnetic field; excitation means for generating an RF excitation magnetic field which produces transverse magnetization in nuclei subjected to the polarizing magnetic field; receiver means for sensing the NMR signal produced by the transverse magnetization and producing digitized in-phase (I) and quadrature (Q) samples of the NMR signal; first gradient means for generating a first magnetic field gradient to impart a first phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a first coordinate axis; second gradient means for generating a second magnetic field gradient to impart a second phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a second coordinate axis; pulse control means coupled to the excitation means, first and second gradient means, and receiver means, said pulse control means being operable to conduct a scan in which a series of pulse sequences are conducted in which the second magnetic field gradient is stepped through a series of discrete values and a corresponding series of NMR signals are sensed and digitized to form an NMR data set; and processor means for storing the NMR data set and for reconstructing an image array for a display from the stored NMR data set by: (a) Fourier transforming the NMR data set along one of its dimensions to create hybrid-space data arrays I' and Q'; (b) producing a correction data array using the data in the hybrid-space data arrays I' and Q'; (c) applying the data in the correction data array to the NMR data set to reduce motion effects; and (d) Fourier transforming the corrected NMR image data set to produce the image array; and in which the NMR data set acquired during the scan includes NMR navigator data which has been subjected to one of said two magnetic field gradients and NMR image data which has been subjected to both of said two magnetic field gradients, and steps (a) and (b) are performed with the NMR navigator data and step (c) is performed on the NMR image data.

Claim 8

An NMR system, the combination comprising: means for generating a polarizing magnetic field; excitation means for generating an RF excitation magnetic field which produces transverse magnetization in nuclei subjected to the polarizing magnetic field; receiver means for sensing the NMR signal produced by the transverse magnetization and producing digitized in-phase (I) and quadrature (Q) samples of the NMR signal; first gradient means for generating a first magnetic field gradient to impart a first phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a first coordinate axis; second gradient means for generating a second magnetic field gradient to impart a second phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a second coordinate axis; pulse control means coupled to the excitation means, first and second gradient means, and receiver means, said pulse control means being operable to conduct a scan in which a series of pulse sequences are conducted in which the second magnetic field gradient is stepped through a series of discrete values and a corresponding series of NMR signals are sensed and digitized to form an NMR data set; and processor means for storing the NMR data set and for reconstructing an image array for a display from the stored NMR data set by: (a) Fourier transforming the NMR data set along one of its dimensions to create hybrid-space data arrays I' and Q'; (b) producing a correction data array using the data in the hybrid-space data arrays I' and Q'; (c) applying the data in the correction data array to the NMR data set to reduce motion effects; and (d) Fourier transforming the corrected NMR image data set to produce the image array; and in which the NMR data set acquired during the scan includes NMR navigator data which has been subjected to one of said two magnetic field gradients and NMR image data which has been subjected to both of said two magnetic field gradients, and steps (a) and (b) are performed with the NMR navigator data and step (c) is performed on the NMR image data.

Claim 9

In an NMR system which performs a scan to acquire an NMR data set from which an image array is reconstructed, the improvement comprising: transforming an NMR data set produced by the NMR system to create a hybrid-space data array by performing a Fourier transformation on the NMR data set along one of its dimensions; producing a correction data array using the data in the hybrid-space data array by calculating the magnitude of each element of the hybrid-space data array to produce a corresponding modulus array, and correlating each row of the modulus array to produce a corresponding shift value for the correction data array; applying the data in the correction data array to an NMR data set produced by the NMR system to reduce artifacts caused by motion in the acquired NMR data set; and producing an image array from the corrected NMR data set.

Claim 10

In an NMR system which performs a scan to acquire an NMR data set from which an image array is reconstructed, the improvement comprising: transforming an NMR data set produced by the NMR system to create a hybrid-space data array by performing a Fourier transformation on the NMR data set along one of its dimensions; producing a correction data array using the data in the hybrid-space data array by calculating the magnitude of each element of the hybrid-space data array to produce a corresponding modulus array, and correlating each row of the modulus array to produce a corresponding shift value for the correction data array; applying the data in the correction data array to an NMR data set produced by the NMR system to reduce artifacts caused by motion in the acquired NMR data set; and producing an image array from the corrected NMR data set.

Claim 11

The improvement as recited in claim 6 in which a rollback correction data array is produced from the corresponding shift values in the correction data array and a rollover rate K R , and the values in both the correction data array and the rollback correction data array are applied to correct said acquired NMR data set used to produce the image array.

Claim 12

In an NMR system which performs a scan to acquire an NMR data set from which an image array is reconstructed, the improvement comprising: transforming an NMR data set produced by the NMR system to create a hybrid-space data array by performing a Fourier transformation of the NMR data set along one of its dimensions; producing a correction data array using the data in the hybrid-space data array by calculating the phase of each element of the hybrid-space data array to produce the corresponding elements of a two-dimensional phase data array, and determining the difference in phase between elements in a reference row of the phase data array and elements in the same column of the phase data array; applying the data in the correction data array to an NMR data set produced by the NMR system to reduce artifacts caused by motion in the acquired NMR data set; and producing an image array from the corrected NMR data set.

Claim 13

In an NMR system which performs a scan to acquire an NMR data set from which an image array is reconstructed, the improvement comprising: transforming an NMR data set produced by the NMR system to create a hybrid-space data array by performing a Fourier transformation of the NMR data set along one of its dimensions; producing a correction data array using the data in the hybrid-space data array by calculating the phase of each element of the hybrid-space data array to produce the corresponding elements of a two-dimensional phase data array, and determining the difference in phase between elements in a reference row of the phase data array and elements in the same column of the phase data array; applying the data in the correction data array to an NMR data set produced by the NMR system to reduce artifacts caused by motion in the acquired NMR data set; and producing an image array from the corrected NMR data set.

Claim 14

The improvement as recited in claim 7 which a second correction data array is produced by: calculating the phase of each element of the hybrid-space data array to produce the corresponding elements of a two-dimensional phase data array having rows and columns; and calculating the elements of the second correction data array by determining the difference in phase between elements in a reference row of the phase data array and elements in the same column of the phase data array; wherein the data in both the correction data array and the second correction data array is applied to the acquired NMR data set to reduce the effects of motion.

Claim 15

The improvement as recited in claim 6 in which the NMR data set used to create the hybrid-space data array is acquired from a navigator NMR signal which is produced during each pulse sequence of a scan but which is not subjected to a changing magnetic field gradient during the scan, and the NMR data set employed to produce the image array is acquired from an NMR signal which is produced during each pulse sequence of the scan and which is subject to a phase encoding magnetic field gradient which changes during the scan.

Claim 16

The improvement as recited in claim 10 in which each navigator NMR signal is produced in the same pulse sequence with its corresponding phase encoded NMR signal.

Claim 17

An NMR system, the combination comprising: means for generating a polarizing magnetic field; excitation means for generating an RF excitation magnetic field which produces transverse magnetization in nuclei subjected to the polarizing magnetic field; receiver means for sensing the NMR signal produced by the transverse magnetization and producing digitized in-phase (I) and quadrature (Q) samples of the NMR signal; first gradient means for generating a first magnetic field gradient to impart a first phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a first coordinate axis; second gradient means for generating a second magnetic field gradient to impart a second phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a second coordinate axis; pulse control means coupled to the excitation means, first and second gradient means, and receiver means, said pulse control means being operable to conduct a scan in which a series of pulse sequences are conducted in which the second magnetic field gradient is stepped through a series of discrete values and a corresponding series of NMR signals are sensed and digitized to form an NMR data set; and processor means for storing the NMR data set and for reconstructing an image array for a display from the stored NMR data set by: (a) producing a phase array from the NMR data set which indicates the phase of the digitized NMR signals; (b) producing correction data using the data in the phase array; (c) applying the correction data to the NMR data set to reduce motion effects; and (d) Fourier transforming the corrected NMR image data set to produce the image array.

Claim 18

An NMR system, the combination comprising: means for generating a polarizing magnetic field; excitation means for generating an RF excitation magnetic field which produces transverse magnetization in nuclei subjected to the polarizing magnetic field; receiver means for sensing the NMR signal produced by the transverse magnetization and producing digitized in-phase (I) and quadrature (Q) samples of the NMR signal; first gradient means for generating a first magnetic field gradient to impart a first phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a first coordinate axis; second gradient means for generating a second magnetic field gradient to impart a second phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a second coordinate axis; pulse control means coupled to the excitation means, first and second gradient means, and receiver means, said pulse control means being operable to conduct a scan in which a series of pulse sequences are conducted in which the second magnetic field gradient is stepped through a series of discrete values and a corresponding series of NMR signals are sensed and digitized to form an NMR data set; and processor means for storing the NMR data set and for reconstructing an image array for a display from the stored NMR data set by: (a) producing a phase array from the NMR data set which indicates the phase of the digitized NMR signals; (b) producing correction data using the data in the phase array; (c) applying the correction data to the NMR data set to reduce motion effects; and (d) Fourier transforming the corrected NMR image data set to produce the image array.

Claim 19

An NMR system, the combination comprising: means for generating a polarizing magnetic field; excitation means for generating an RF excitation magnetic field which produces transverse magnetization in nuclei subjected to the polarizing magnetic field; receiver means for sensing the NMR signal produced by the transverse magnetization and producing digitized in-phase (I) and quadrature (Q) samples of the NMR signal; first gradient means for generating a first magnetic field gradient to impart a first phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a first coordinate axis; second gradient means for generating a second magnetic field gradient to impart a second phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a second coordinate axis; pulse control means coupled to the excitation means, first and second gradient means, and receiver means, said pulse control means being operable to conduct a scan in which a series of pulse sequences are conducted in which the second magnetic field gradient is stepped through a series of discrete values and a corresponding series of NMR signals are sensed and digitized to form an NMR data set; and processor means for storing the NMR data set and for reconstructing an image array for a display from the stored NMR data set by: (a) producing a phase array from the NMR data set which indicates the phase of the digitized NMR signals; (b) producing an altered phase array by subtracting phase components produced by stationary spins from each value in the phase array; (c) producing correction data using the data in the altered phase array; (d) applying the correction data to the NMR data set to reduce motion effects; and (e) transforming the corrected NMR image data set to produce the image array.

Claim 20

An NMR system, the combination comprising: means for generating a polarizing magnetic field; excitation means for generating an RF excitation magnetic field which produces transverse magnetization in nuclei subjected to the polarizing magnetic field; receiver means for sensing the NMR signal produced by the transverse magnetization and producing digitized in-phase (I) and quadrature (Q) samples of the NMR signal; first gradient means for generating a first magnetic field gradient to impart a first phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a first coordinate axis; second gradient means for generating a second magnetic field gradient to impart a second phase component into the NMR signal which is indicative of the location of the transversely magnetized nuclei along a second coordinate axis; pulse control means coupled to the excitation means, first and second gradient means, and receiver means, said pulse control means being operable to conduct a scan in which a series of pulse sequences are conducted in which the second magnetic field gradient is stepped through a series of discrete values and a corresponding series of NMR signals are sensed and digitized to form an NMR data set; and processor means for storing the NMR data set and for reconstructing an image array for a display from the stored NMR data set by: (a) producing a phase array from the NMR data set which indicates the phase of the digitized NMR signals; (b) producing an altered phase array by subtracting phase components produced by stationary spins from each value in the phase array; (c) producing correction data using the data in the altered phase array; (d) applying the correction data to the NMR data set to reduce motion effects; and (e) transforming the corrected NMR image data set to produce the image array.

Claim 21

The NMR system as recited in claim 13 in which the phase components produced by stationary spin are calculated by determining the center of a circle which best fits the values in each column of the phase array.