US4931546A
Expired / Lapsed
US
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Process for the treatment of collagen, notably for facilitating its cross-linking, and the collagen obtained by the application of the said process
Assignee: DEVELOPMENT DES UTILISATIONS DU CUIR-SADUC SA
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Filing: 1987-07-13
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Granted: 1990-06-05
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Expires: 2007-07-13
Abstract
Abstract Collagen is submitted to a controlled oxidation by treatment with a solution of periodic acid or of a periodate, notably of sodium. Application to gels, implants, lenses, films, spheres, etc., of collagen.
Inventors
- 👤 Michel Tardy
- 👤 Jean-Louis Tayot
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:41
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; C; C08; C08H; C08H1/00; C08H1/06; C12; C12N; C12N11/00; C12N11/02; C12N9/00; C12N9/96; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
40 words
A process for reticulating collagen and permitting the obtaining of a reticulated collagen with improved stability and mechanical characteristics, comprising submitting a non-reticulated collagen to a controlled oxidation by treatment with a solution of periodic acid or of a periodate.
Claim 2
Dependent Claim
40 words
A process for reticulating collagen and permitting the obtaining of a reticulated collagen with improved stability and mechanical characteristics, comprising submitting a non-reticulated collagen to a controlled oxidation by treatment with a solution of periodic acid or of a periodate.
Claim 3
Dependent Claim
15 words
The process according to claim 1, wherein it is carried out on a collagen solution.
Claim 4
Dependent Claim
17 words
The process according to claim 1, wherein it is carried out on an already constituted collagen gel.
Claim 5
Dependent Claim
20 words
The process according to claim 1, wherein it is carried out on collagen in the form of powders or films.
Claim 6
Dependent Claim
48 words
The process according to claim 1, wherein, when it is applied to the preparation of a gel, a solution of sodium periodate, up till a concentration of 10 -1 to 10 -4 M is obtained, is added to the collagen solution, the pH being between 2 and 8.
Claim 7
Dependent Claim
30 words
The process according to claim 5, wherein the treatment is carried out in two stages, the first at an acid pH and the second at a neutral or basic pH.
Claim 8
Dependent Claim
52 words
The process according to claim 1, wherein the already constituted gel is treated with a solution of sodium periodate at a concentration of between 10 -1 to 10 -4 M, at a pH, at least in the second stage, of between 5 and 8, for 3 to 20 hours at ambiant temperature.
Claim 9
Dependent Claim
46 words
The process according to claim 1, wherein collagen powders or films are treated with a solution of sodium periodate at a concentration of between 10 -1 to 10 -4 M, at a pH of between 5 and 8, for 3 to 20 hours at ambiant temperature.
Claim 10
Dependent Claim
17 words
The process according to claim 1, wherein it may be followed by a washing or neutralization step.
Claim 11
Dependent Claim
17 words
The process according to claim 9, wherein the washing is carried out using a solutin of glycine.
Claim 12
Dependent Claim
17 words
The process according to claim 9, wherein the washing is carried out using a solution of ethanolamine.
Claim 13
Dependent Claim
18 words
The process according to claim 9, wherein the washing is carried out using a solution of sodium hydroborate.
Claim 14
Dependent Claim
15 words
The process according to claim 1, wherein it may be followed by a surface curing.
Claim 15
Dependent Claim
19 words
The process according to claim 13, wherein the surface curing is carried out using a solution of sodium periodate.
Claim 16
Dependent Claim
20 words
The process according to claim 13, wherein the surface curing is carried out using a solution of di- or polyaldehyde.
Claim 17
Dependent Claim
44 words
The process according to claim 13, wherein the surface curing is carried out using a solution of sodium periodate the concentration of which is between 10 -1 to 10 -4 M, at a pH of between 5 and 8, for 3 to 20 hours.
Claim 18
Dependent Claim
42 words
The process according to claim 13, wherein the surface curing is carried out using a solution of di- or polyaldehyde the concentration of which is between 0.1 and 0.001M, at a pH of between 5 and 8, for 3 to 20 hours.
Claim 19
Dependent Claim
23 words
An application of the collagenic solutions treated by the process according to claim 1, to the preparation of powders, fibers, spheres or films.
Claim 20
Dependent Claim
22 words
A collagen gel with improved stability and mechanical characteristics, wherein it is obtained by application of the process according to claim 1.
Claim 21
Dependent Claim
27 words
A reticulated collagen in the form of powders or gels, with improved stability and mechanical characteristics, wherein it is subjected to a treatment according to claim 1.
Claim 22
Dependent Claim
23 words
A collagen gel with reactive groups useable for subsequent bonding, wherein it is obtained by application of the process according to claim 1.
Claim 23
Dependent Claim
29 words
A collagen in the form of powders or gels with reactive groups useable for subsequent bonding, wherein it is obtained by application of the process according to claim 1.
Claim 24
Dependent Claim
20 words
Process according to claim 1 wherein the controlled oxidation is carried out by treatment with a solution of sodium periodate.
Claim 25
Dependent Claim
26 words
Collagen gel according to claim 22, wherein the reactive groups are linked to biologically active molecules permitting a better biocompatibility and a greater resistance to biodegradation.
Claim 26
Dependent Claim
26 words
Collagen gel according to claim 24, wherein the biologically active molecules are selected from proteins, fibronectin, growth factors, glycosaminoglycans, enzymes, bacteriocidal or bacteriostatic agents and antibiotics.
Claim 27
Dependent Claim
27 words
Collagen in the form of powders or gels according to claim 22, wherein the reactive groups are linked to biologically active molecules as defined in claim 23.
References Cited (Backward Citations)
US4280954A
Cited
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