Amides of paramethoxycinnamic and utilization thereof as solar filters

Claim 2

An amide of the formula: ##STR13## in which: the ethylenic double bond can exist either in the trans form or in the cis form; R 1 individually represents hydrogen, and R 2 individually represents: an aryl group, a group of the formula: ##STR14## where X and Y can be an alkyl group or an aryl group, a group of the formula ##STR15## where Z can be hydrogen, an alkyl group or an aryl group and where n is an integer between 1 and 6, or a group of the formula; ##STR16## to which two molecules of filter chromophores of the paramethoxycinnamic acid are attached; or ##STR17## can be a peptide structure comprising two or more amino acids in which the terminal or branched acid or amine functional groups can be free or part of ester or amide groups; wherein said alkyl groups have 1-12 carbon atoms, and said aryl groups are substituted or unsubstituted benzyl or phenyl groups or homologs thereof, or furanyl, pyridinyl, or oxazolyl groups.

Claim 3

Amide as claimed in claim 1, wherein ##STR18## represents an amino ester or peptide radical not containing sulfur, of the L-tyrosine or L-histidine type.

Claim 4

Amide as claimed in claim 1, wherein ##STR19## represents a sulfur-containing amino ester or peptide radical of the methionine, cysteine, S-methylcysteine, S-benzylcysteine, cysteine, glutathione or oxidized glutathione type.

Claim 5

Amide of claim 1, wherein ##STR20## represents a peptide of tyrosine/glutamic acid structure.

Claim 6

An amide in accordance with claim 1, wherein R 2 represents a group of the formula ##STR21##

Claim 7

A therapeutic method for protecting human skin from solar radiation, comprising the step of topically applying to skin of a human who is in need of said therapy a therapeutic amount of an amide of the formula ##STR22## in which: the ethylenic double bond can exist either in the trans form or in the cis form; R 1 individually represents hydrogen; and R 2 individually represents: an aryl group, a group of the formula: ##STR23## where X and Y can be an alkyl group or an aryl group, a group of the formula: ##STR24## where Z can be hydrogen, an alkyl group or an aryl group and where n is an integer between 1 and 6, or a group of the formula: ##STR25## to which two molecules of filter chromophores of the paramethoxycinnamic acid are attached; or ##STR26## can be a peptide structure comprising two or more amino acids in which the terminal or branched acid or amine-functional groups can be free or part of ester or amide groups; wherein said alkyl groups have 1-12 carbon atoms, and said aryl groups are substituted or unsubstituted benzyl or phenyl groups or homologs thereof, or furanyl, pyridinyl, or oxazolyl groups.

Claim 8

A therapeutic method for protecting human skin from solar radiation, comprising the step of topically applying to skin of a human who is in need of said therapy a therapeutic amount of an amide of the formula ##STR22## in which: the ethylenic double bond can exist either in the trans form or in the cis form; R 1 individually represents hydrogen; and R 2 individually represents: an aryl group, a group of the formula: ##STR23## where X and Y can be an alkyl group or an aryl group, a group of the formula: ##STR24## where Z can be hydrogen, an alkyl group or an aryl group and where n is an integer between 1 and 6, or a group of the formula: ##STR25## to which two molecules of filter chromophores of the paramethoxycinnamic acid are attached; or ##STR26## can be a peptide structure comprising two or more amino acids in which the terminal or branched acid or amine-functional groups can be free or part of ester or amide groups; wherein said alkyl groups have 1-12 carbon atoms, and said aryl groups are substituted or unsubstituted benzyl or phenyl groups or homologs thereof, or furanyl, pyridinyl, or oxazolyl groups.

Claim 9

The method of claim 6, wherein ##STR27## represents a sulfur-containing amine ester radical or peptide of the methionine, cysteine, S-methylcysteine, S-benzylcysteine, cystine, glutathione or oxidized glutathione type.

Claim 10

The method of claim 6 wherein R 2 represents a group of the formula ##STR28##

Claim 11

The method of claim 6, wherein ##STR29## represents a sulfur-containing amino ester radical or peptide of the methionine, cysteine, S-methylcysteine, S-benzylcysteine, cystine, glutathione or oxidized glutathione type.