US4927632A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Selective pulsed drug delivery system
Assignee: Alza Corp
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Filing: 1988-06-29
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Granted: 1990-05-22
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Expires: 2008-06-29
Abstract
Abstract This invention pertains to a programmable delivery system.
Inventors
- 👤 Patrick S.-L. Wong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 09:25
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
166 words
A delivery system for delivering a beneficial drug at a controlled rate to a biological environment, wherein the delivery system comprises: (a) a reservoir dimensioned for use and retention in the biological environment, the reservoir comprising a polymeric formulation that permits the passage of drug; (b) a beneficial drug in the reservoir; (c) a first membrane in contacting relation with a surface of the reservoir, the membrane comprising a material substantially impermeable to the passage of an osmagent; (d) an osmagent in the first membrane in contacting relation with a surface of the reservoir; (e) a second membrane in contact with a different surface of the reservoir, the second membrane comprising a material substantially impermeable to the passage of an osmagent; and (f) an osmagent in the second membrane in contacting relation with a different surface of the reservoir, and wherein, when the delivery system is in operation in the biological environment, beneficial drug is released by the formation of osmotically-bursting apertures in (c) and (e).
Claim 2
Dependent Claim
166 words
A delivery system for delivering a beneficial drug at a controlled rate to a biological environment, wherein the delivery system comprises: (a) a reservoir dimensioned for use and retention in the biological environment, the reservoir comprising a polymeric formulation that permits the passage of drug; (b) a beneficial drug in the reservoir; (c) a first membrane in contacting relation with a surface of the reservoir, the membrane comprising a material substantially impermeable to the passage of an osmagent; (d) an osmagent in the first membrane in contacting relation with a surface of the reservoir; (e) a second membrane in contact with a different surface of the reservoir, the second membrane comprising a material substantially impermeable to the passage of an osmagent; and (f) an osmagent in the second membrane in contacting relation with a different surface of the reservoir, and wherein, when the delivery system is in operation in the biological environment, beneficial drug is released by the formation of osmotically-bursting apertures in (c) and (e).
Claim 3
Dependent Claim
150 words
A delivery system for delivering a beneficial drug at a controlled rate to a biological environment, wherein the system comprises: (a) a multiplicity of reservoirs in consecutive spaced apart parallel arrangement, the reservoirs comprising a polymeric formulation that permits the passage of a drug; (b) a beneficial drug in the multiplicity of reservoirs; (c) a multiplicity of membranes in consecutive spaced apart parallel arrangement positioned between the spaced apart reservoirs, said membranes comprising a polymeric formulation substantially impermeable to the passage of an osmagent; and, (d) an osmagent in the multiplicity of membranes, said osmagent present in an amount selected from an amount that produces a short start-up time for drug delivery and in an amount that produces a long start-up time for drug delivery, and wherein when the delivery system is in operation in the biological environment, beneficial drug is released by the formation of osmotically-bursting apertures in (c).
Claim 4
Dependent Claim
150 words
A delivery system for delivering a beneficial drug at a controlled rate to a biological environment, wherein the system comprises: (a) a multiplicity of reservoirs in consecutive spaced apart parallel arrangement, the reservoirs comprising a polymeric formulation that permits the passage of a drug; (b) a beneficial drug in the multiplicity of reservoirs; (c) a multiplicity of membranes in consecutive spaced apart parallel arrangement positioned between the spaced apart reservoirs, said membranes comprising a polymeric formulation substantially impermeable to the passage of an osmagent; and, (d) an osmagent in the multiplicity of membranes, said osmagent present in an amount selected from an amount that produces a short start-up time for drug delivery and in an amount that produces a long start-up time for drug delivery, and wherein when the delivery system is in operation in the biological environment, beneficial drug is released by the formation of osmotically-bursting apertures in (c).
References Cited (Backward Citations)
US3993072A
Cited
US4077407A
Cited
US4160020A
Cited
US4008719A
Cited
US4014334A
Cited
US4058122A
Cited
US4111203A
Cited
US4160452A
Cited
US4256108A
Cited
US4432964A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-21 | 1993-11-20 | 1994-05-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-21 | 1997-11-20 | 1998-05-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-21 | 2001-11-20 | 2002-05-22 | $7700.00 | Window Closed / Lapsed |