US4924024A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phosphorus-containing squalene synthetase inhibitors, new intermediates and method
Assignee: ER Squibb and Sons LLC
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Filing: 1989-06-01
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Granted: 1990-05-08
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Expires: 2009-06-01
Abstract
Abstract Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## wherein Q is ##STR2## or a bond; Z is --(CH 2 ) n -- or --(CH 2 ) p --CH═CH--(CH 2 ) m --, wherein n is 1 to 5; p is 0, 1 or 2; m is 0, 1 or 2; R, R 1 and R 1a are the same or different and are H, lower alkyl or a metal ion; and R 2 and R 3 may be the same or different and are H or halogen. New intermediates used in preparing the above compounds and method for preparing same, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.
Inventors
- 👤 Scott A. Biller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 13:00
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/42; C07F9/425; C07F9/3804; C07F9/3808; C07F9/3821; C07F9/40; C07F9/4003; C07F9/4006; C07F9/4012; C07F9/4015
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
50 words
A compound having the structure ##STR41## wherein R 5 is OH or Cl and Q is ##STR42## or a bond; and Z is --(CH 2 )n- or -(CH 2 )p-CH═CH-(CH 2 )m-, wherein n is 1 to 5; p is 0, 1 or 2; m is 0, 1 or 2.
Claim 2
Dependent Claim
50 words
A compound having the structure ##STR41## wherein R 5 is OH or Cl and Q is ##STR42## or a bond; and Z is --(CH 2 )n- or -(CH 2 )p-CH═CH-(CH 2 )m-, wherein n is 1 to 5; p is 0, 1 or 2; m is 0, 1 or 2.
Claim 3
Dependent Claim
12 words
The compound as defined in claim 1 wherein R 5 is OH.
Claim 4
Dependent Claim
12 words
This compound as defined in claim 1 wherein R 5 is Cl.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-07 | 1993-11-06 | 1994-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-07 | 1997-11-06 | 1998-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-07 | 2001-11-06 | 2002-05-08 | $7700.00 | Window Closed / Lapsed |