US4923685A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antimicrobial flavored compositions having particular utility as mouth washes
Assignee: Henkel AG and Co KGaA
•
Filing: 1988-07-28
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Granted: 1990-05-08
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Expires: 2008-07-28
Abstract
Abstract Aqueous homogeneous preparations containing 0.0025 to 0.1% by weight antimicrobial biguanide compounds, 0.005 to 0.2% by weight of an alkyl glycoside, 0.01 to 0.3% by weight of a water-insoluble aromatic oil, 0.01 to 0.3% by weight of a solubilizer from the group consisting of ethoxylated fatty acid glycerides, ethoxylated fatty acid sorbitan partial esters or fatty acid partial esters of glycerol or sorbitan ethoxylates show high activity despite the low concentration of antimicrobial biguanide compounds. The clear solubility is obtained without ethanol or with only very small contents of up to 15% by weight of ethanol. The preparations are particularly suitable as mouthwashes.
Inventors
- 👤 Peter Wuelknitz
- 👤 Rudolf Lehmann
- 👤 Walter Ploeger
- 👤 Karlheinz Hill
- 👤 Franz Forg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 17:27
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/4993; A61K8/40; A61K8/43; A61K8/60; A61K8/604; A61Q; A61Q11/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
114 words
An aqueous homogeneous composition containing an antimicrobial biguanide compound and an alkyl glycoside, comprising (A) from about 0.0025 to about 0.1% by weight of an antimicrobial biguanide compound, (B) from about 0.005 to about 0.2% by weight of an alkyl glycoside containing 8 to 16 carbon atoms in the alkyl group and having an average degree of oligomerization of the glycoside commonent of from 1 to 8. (C) from about 0.01 to about 0.3% by weight of a water-insoluble aromatic oil, (D) from about 0.01 to about 0.3% by weight of a solubilizer selected from the group consisting of ethoxylated fatty acid sorbitan partial esters, fatty acid partial esters of glycerol, or sorbitan ethoxylates.
Claim 2
Dependent Claim
114 words
An aqueous homogeneous composition containing an antimicrobial biguanide compound and an alkyl glycoside, comprising (A) from about 0.0025 to about 0.1% by weight of an antimicrobial biguanide compound, (B) from about 0.005 to about 0.2% by weight of an alkyl glycoside containing 8 to 16 carbon atoms in the alkyl group and having an average degree of oligomerization of the glycoside commonent of from 1 to 8. (C) from about 0.01 to about 0.3% by weight of a water-insoluble aromatic oil, (D) from about 0.01 to about 0.3% by weight of a solubilizer selected from the group consisting of ethoxylated fatty acid sorbitan partial esters, fatty acid partial esters of glycerol, or sorbitan ethoxylates.
Claim 3
Dependent Claim
18 words
The composition of claim 1 additionally containing ethanol in an amount of about 15% by weight or less.
Claim 4
Dependent Claim
24 words
The composition of claim 1, wherein the antimicrobial biguanide compound is present in a quantity of from about 0.0025 to about 0.04% by weight.
Claim 5
Dependent Claim
21 words
The composition of claim 1 containing 1,1'-hexamethylene-bis-(4-chlorophenyl)-biguanide in the form of a water-insoluble, physiologically compatible salt as the antimicrobial biguanide compound.
Claim 6
Dependent Claim
45 words
The composition of claim 1, wherein the alkyl glycoside is one containing 8 to 14 carbon atoms in the alkyl and having at least one branch in the alkyl group and an average degree of oligomerization of the glycoside component of from 1 to 4.
Claim 7
Dependent Claim
59 words
The composition of claim 1, wherein the water-insoluble aromatic oil is selected from the group consisting of peppermint oil, spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, geranium oil, sage oil, pimento oil, thyme oil, marjoram oil, basil oil, citrus oil or an isolated or synthetic component of these oils.
Claim 8
Dependent Claim
25 words
The composition of claim 1 containing an adduct of 20 to 60 mols of ethylene oxide with hardened or unhardened castor oil as a solubilizer.
Claim 9
Dependent Claim
49 words
Solid or liquid concentrates for making the preparations claimed in claim 1, wherein components A, B, C and D are present in such a concentration that the compositions are produced by dissolution in or dilution with water in a ratio by weight component to water of 1:1 to 1:500.
Claim 10
Dependent Claim
118 words
The composition of claim 1, wherein the biguanide is 1,1'-hexamethylene bis-(4-chlorophenyl)-biguanide in the form of a water soluble physiologically compatible salt, the alkyl glycoside is one in which the alkyl contains from 8 to 14 carbon atoms and has at least one branch in the alkyl and an average degree of oligomerization of the glycoside component of from 1 to 41, and the water insoluble aromatic oil is selected from the group consisting of peppermint oil, spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, geranium oil, sage oil, pimento oil, thyme oil, marjoram oil, basil oil, citrus oil or one or more isolated or synthetic components of these oils.
Claim 11
Dependent Claim
25 words
The composition of claim 9 containing an adduct of 20 to 60 mols of ethylene oxide with hardened or unhardened castor oil as a solubilizer.
References Cited (Backward Citations)
GB705838A
Cited
US2684924A
Cited
US2990425A
Cited
US3468898A
Cited
US3547828A
Cited
US3772269A
Cited
US3707535A
Cited
US3839318A
Cited
US3842168A
Cited
US3843779A
Cited
US3937805A
Cited
US3804946A
Cited
US3934002A
Cited
US3947570A
Cited
US3864472A
Cited
US3989813A
Cited
US4025616A
Cited
US3937807A
Cited
US4051234A
Cited
US4198392A
Cited
US4241049A
Cited
US4053636A
Cited
US4150151A
Cited
US4206198A
Cited
US4349669A
Cited
CA1145261A
Cited
US4323552A
Cited
US4343785A
Cited
EP0077167A1
Cited
US4476107A
Cited
US4820507A
Cited
US4726943A
Cited
US4748158A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-07 | 1993-11-06 | 1994-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-07 | 1997-11-06 | 1998-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-07 | 2001-11-06 | 2002-05-08 | $7700.00 | Window Closed / Lapsed |