Quinoline derivatives and use thereof as antagonists of leukotriene D4

Claim 1

A compound of the formula ##STR25## where: A is O or S; B is a chemical bond, O, S, SO, SO 2 , NR 1 , ##STR26## D is O, S, NR 1 , ##STR27## or a chemical bond; E is a chemical bond or ##STR28## a is 0-2; b is 0-1; c is 0-4; d is 0-5; e is 0-4; f is 0-5; n is 0-2; R' is independently hydrogen, alkyl having 1 to 6 carbon atoms, hydroxy, alkoxy having 1 to 6 carbon atoms, carboxy, carbalkoxy wherein alkoxy has 1 to 6 carbon atoms, halo, nitro, trifluoromethyl, cyano, acetyl, propionyl or benzoyl; R" is independently hydrogen, hydroxy, alkoxy having 1 to 6 carbon atoms, halo, trifluoromethyl, --CH 2 R, --CH 2 --O--(CH 2 ) x --X or R; R 1 is independently hydrogen, alkyl having 1 to 6 carbon atoms, benzyl or phenethyl; R is --(CH 2 ) x --X, --O--(CH 2 ) x --X (when not geminal to A or B when A or B is O); --S--(CH 2 ) x --X or --NR 1 --(CH 2 ) x --X where x is 0-3; and X is hydrogen, alkyl having 1 to 6 carbon atoms, alkenyl having 2 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, phenyl, benzyl, phenethyl, hydroxy, alkoxy having 1 to 6 carbon atoms, aralkoxy wherein aryl is phenyl and alkoxy has 1 to 6 carbon atoms, amino, mono- and di-alkylamino having 1 to 6 carbon atoms, benzylamino, phenethylamino, acetylamino, propionylamino, benzoylamino, --CONR 1 R 1 , --COOR, --CN, tetrazolyl, acetylsulfonamido, propionylsulfonamido or benzoylsulfonamido; vicinal R groups together may be (CH 2 ) y -- where y is 1-4, thus forming a 3-6 membered ring; geminal R 1 and R groups may together form a spiro substituent, --(CH 2 ) z --, where z is 2 to 5; geminal R 1 or R 1 and R groups may together form an alkylidenyl substituent, ##STR29## Z is --COOR 1 ; --CN; ##STR30## where R 3 is hydrogen, alkyl having 1 to 6 carbon atoms, trifluoromethyl, phenyl or benzyl; ##STR31## --OR 1 or tetrazolyl or substituted tetrazolyl where the substituent may be alkyl having 1 to 6 carbon atoms, carboxyalkyl wherein alkyl has 1 to 6 carbon atoms, or carbalkoxyalkyl wherein alkoxy has 1 to 6 carbon atoms and alkyl has 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof.