Patent JPS5423818A successfully refreshed from Google Patents.
US4919664A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stimulation of hair growth
Assignee: University of Dundee
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Filing: 1987-02-19
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Granted: 1990-04-24
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Expires: 2007-02-19
Abstract
Abstract The present invention relates to a method of stimulating hair growth in part of the skin of a mammal. The method comprises selecting lower follicular dermal cells and culturing them. An opening is then formed in the skin and the cultured dermal cells introduced through the opening in the outer epidermis layer of the skin into contact with the dermis, with said cultured dermal cells in association with epidermis cells. The invention also provides a hair growth stimulating combination comprising cultured lower follicular dermal cells in admixture with epidermis cells, as well as such cultured dermal cells for use in the preparation of an injection composition for stimulating hair growth in human skin.
Inventors
- 👤 Roy F. Oliver
- 👤 Colin A. B. Jahoda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 13:12
CPC Classifications
C; C12; C12N; C12N5/00; C12N5/06; C12N5/0602; C12N5/0625; C12N5/0627; A; A61; A61K; A61K35/00; A61K35/12; A61K35/36; A61K8/00; A61K8/18; A61K8/96; A61K8/98; A61K8/981; A61K8/985; A61Q; A61Q7/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
118 words
A method of inducing hair follicle development and hair growth of a desired hair type in part of the skin of a mammal said skin having an outer epidermis layer and an inner dermis layer, which method comprises the steps of: selecting at least one lower follicular dermal cell to provide selected dermal cell, culturing the selected dermal cell so as to produce cultured dermal cells; forming an opening in the outer epidermis layer of said part of the mammal; and introducing cultured dermal cells through said opening in the epidermis layer into contact with the dermis layer in proximity to the epidermis and with at least some of said cultured dermal cells in contact with epidermal cells.
Claim 2
Independent Claim
118 words
A method of inducing hair follicle development and hair growth of a desired hair type in part of the skin of a mammal said skin having an outer epidermis layer and an inner dermis layer, which method comprises the steps of: selecting at least one lower follicular dermal cell to provide selected dermal cell, culturing the selected dermal cell so as to produce cultured dermal cells; forming an opening in the outer epidermis layer of said part of the mammal; and introducing cultured dermal cells through said opening in the epidermis layer into contact with the dermis layer in proximity to the epidermis and with at least some of said cultured dermal cells in contact with epidermal cells.
Claim 3
Dependent Claim
27 words
A method as claimed in claim 1 wherein said cultured dermal cells are subjected to aggregation by an aggregation means thereby enhancing interaction with the epidermal cells.
Claim 4
Dependent Claim
26 words
A method as claimed in claim 2 wherein said cultured dermal cells are treated with means for causing aggregation comprising an aggregation promoting glycoprotein, or glycosaminoglycan.
Claim 5
Dependent Claim
27 words
A method as claimed in claim 1 wherein said opening is in the form of a narrow incision having a depth of from 0.4 to 6 mm.
Claim 6
Dependent Claim
52 words
A method as claimed in claim 1 which method includes the step of inducing a blister defining a blister cavity in said part of the skin, and wherein said opening is made in part of the epidermis layer at said blister, and said cultured dermal cells are introduced into the blister cavity.
Claim 7
Dependent Claim
44 words
A method as claimed in claim 1 wherein a sheet of epidermis is formed into a pocket and the cultured dermal cells are enclosed inside said pocket of epidermis prior to introduction of said cultured dermal cells through said opening in the epidermis layer.
Claim 8
Dependent Claim
22 words
A method as claimed in claim 1 wherein the dermal cells are introduced in the form of a mixture with epidermal cells.
Claim 9
Dependent Claim
25 words
A method as claimed in claim 7 wherein said epidermal cells are selected from epidermal cells of inter-follicular origin and epidermal cells of intra-follicular origin.
Claim 10
Dependent Claim
34 words
A method as claimed in claim 1 wherein said mammal is additionally treated with a hair growth stimulating promoter so as to enhance growth of new hair induced by said introduced cultured dermal cells.
Claim 11
Dependent Claim
23 words
A method as claimed in claim 1 wherein said selected dermal cell comprise at least one of dermal papilla and dermal sheath cells.
Claim 12
Dependent Claim
17 words
A method as claimed in claim 1 wherein said selected dermal cells are of human scalp origin.
Claim 13
Independent Claim
119 words
A method of treatment of the scalp skin area of a human subject, which area has sufficient hair loss and which has an outer epidermis layer and an inner dermis layer, which method comprises the steps of: (a) selecting at least one human scalp lower follicular dermal cell; (b) culturing at least one human scalp dermal cell so as to produce cultured dermal cells; (c) forming an opening in the outer epidermis layer of said human scalp skin area; and (d) introducing said cultured dermal cells through said opening in the epidermis layer into contact with the dermis layer in proximity to the epidermis and with at least some of said cultured dermal cells in contact with epidermal cells.
Claim 14
Independent Claim
119 words
A method of treatment of the scalp skin area of a human subject, which area has sufficient hair loss and which has an outer epidermis layer and an inner dermis layer, which method comprises the steps of: (a) selecting at least one human scalp lower follicular dermal cell; (b) culturing at least one human scalp dermal cell so as to produce cultured dermal cells; (c) forming an opening in the outer epidermis layer of said human scalp skin area; and (d) introducing said cultured dermal cells through said opening in the epidermis layer into contact with the dermis layer in proximity to the epidermis and with at least some of said cultured dermal cells in contact with epidermal cells.
Claim 15
Dependent Claim
28 words
The method of treatment of claim 12 which includes the step of obtaining said at least one lower follicular dermal cell from the scalp of said human subject.
Claim 16
Dependent Claim
28 words
The method of treatment of claim 12 which includes the step of obtaining said at least one lower follicular dermal cell from the scalp of another human subject.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-23 | 1993-10-23 | 1994-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-23 | 1997-10-23 | 1998-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-23 | 2001-10-23 | 2002-04-24 | $7700.00 | Window Closed / Lapsed |