US4918166A
Expired / Lapsed
US
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Particulate hybrid HIV antigens
Assignee: Vernalis R&D Ltd
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Filing: 1987-10-26
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Granted: 1990-04-17
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Expires: 2007-10-26
Abstract
Abstract Fusion proteins comprise a77 first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles; an example is the product of the YTA gene of the yeast retrotransposon Ty. The second amino acid sequence is an HIV antigen. So particles formed of the fusion proteins may be useful in vaccines or in diagnostic or purification applications.
Inventors
- 👤 Alan J. Kingsman
- 👤 Susan M. Kingsman
- 👤 Sally E. Adams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 05:40
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/87; C12N15/90; C07; C07K; C07K14/00; C07K14/005; C12N15/11; C12N15/62; C12N15/63; C12N15/79; C12N15/80; C12N15/81; C07K2319/00; C07K2319/40; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/16011; C12N2740/16111; C12N2740/16122; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S530/81; Y10S530/812; Y10S530/82; Y10S530/823; Y10S530/824; Y10S530/826
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
60 words
A particle comprising a plurality of fusion proteins, each fusion protein comprising a first amino acid sequence and a second amino acid sequence, wherein the first amino acid sequence is substantially homologous with a particle-forming protein encoded by a yeast TYA gene without TYP gene sequence and wherein the second amino acid sequence is substantially homologous to an HIV antigen.
Claim 2
Dependent Claim
60 words
A particle comprising a plurality of fusion proteins, each fusion protein comprising a first amino acid sequence and a second amino acid sequence, wherein the first amino acid sequence is substantially homologous with a particle-forming protein encoded by a yeast TYA gene without TYP gene sequence and wherein the second amino acid sequence is substantially homologous to an HIV antigen.
Claim 3
Dependent Claim
13 words
A diagnostic reagent comprising particles of claim 7 dispersed on a solid support.
Claim 4
Dependent Claim
28 words
A particle according to claim 7 wherein the second amino acid sequence is immunologically reactive to antibodies which are immunologically reactive to HIV proteins p24, p41 or p120.
References Cited (Backward Citations)
US4722840A
Cited
WO1986007090A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-16 | 1993-10-16 | 1994-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-16 | 1997-10-16 | 1998-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-16 | 2001-10-16 | 2002-04-17 | $7700.00 | Window Closed / Lapsed |