US4917119A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug delivery article
Assignee: RJ Reynolds Tobacco Co
•
Filing: 1988-11-30
•
Granted: 1990-04-17
•
Expires: 2008-11-30
Abstract
Abstract A drug delivery article provides a dose of a volatilized drug by heating a drug carrying substrate, but not burning any material. A heat source which includes a metal oxide (e.g., calcium oxide), an anhydrous metal sulfate (e.g., magnesium sulfate), an inorganic salt and a sugar, generates heat upon contact of water therewith. The heat produced by the heat source heats the drug in a heat exchange relationship therewith. The drug volatilizes and is drawn into the mouth of the user of the article. Typical heat sources heat the drug to a temperature within 70° C. to 200° C. for 4 to 8 minutes.
Inventors
- 👤 Dennis L. Potter
- 👤 Mark L. Raker
- 👤 Henry T. Ridings
- 👤 Andrew J. Sensabaugh, Jr.
- 👤 Amos E. Westmoreland
- 👤 Donna K. Woods
- 👤 Chandra K. Banerjee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:44
CPC Classifications
A; A24; A24F; A24F42/00; A24F42/10
Claims Analysis
Total Claims: 79
Claim 1
Independent Claim
59 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and a third chemical agent capable of interacting exothermically with the first chemical agent, and (ii) a dispersing agent for the first agent.
Claim 2
Dependent Claim
59 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and a third chemical agent capable of interacting exothermically with the first chemical agent, and (ii) a dispersing agent for the first agent.
Claim 3
Dependent Claim
51 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and (ii) a dispersing agent for the first agent, and (iii) a phase change material.
Claim 4
Dependent Claim
51 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and (ii) a dispersing agent for the first agent, and (iii) a phase change material.
Claim 5
Dependent Claim
24 words
The article of claim 2, wherein the heat source further includes a third chemical agent capable of interacting exothermically with the first chemical agent.
Claim 6
Dependent Claim
16 words
The article of claim 1 or 2, wherein the drug is carried by a fibrous substrate.
Claim 7
Dependent Claim
14 words
The article of claim 3, wherein the drug is carried by a fibrous substrate.
Claim 8
Dependent Claim
20 words
The article of claim 2, wherein the phase change material has a solid form prior to use of the article.
Claim 9
Dependent Claim
15 words
The article of claim 1 or 2, wherein the dispersing agent has a granular form.
Claim 10
Dependent Claim
46 words
The article of claim 1 or 2, wherein the heat source is capable of heating at least a portion of the drug to a temperature in excess of about 70° C. within 20 seconds from the time that exothermic interaction of the chemical agents is initiated.
Claim 11
Dependent Claim
46 words
The article of claim 1 or 2, wherein the heat source is capable of heating at least a portion of the drug to a temperature in excess of about 70° C. within 10 seconds from the time that exothermic interaction of the chemical agents is initiated.
Claim 12
Dependent Claim
33 words
The article of claim 1 or 2, wherein the heat source is such that the article is not heated to a temperature above about 350° C. during the life of the heat source.
Claim 13
Dependent Claim
33 words
The article of claim 1 or 2, wherein the heat source is such that the drug is not heated to a temperature above about 180° C. during the life of the heat source.
Claim 14
Dependent Claim
43 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) at least one chemical agent capable of interacting exothermically with water, and (ii) a dispersing agent for the chemical agent.
Claim 15
Dependent Claim
43 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) at least one chemical agent capable of interacting exothermically with water, and (ii) a dispersing agent for the chemical agent.
Claim 16
Dependent Claim
15 words
The article of claim 12, wherein the heat source further includes a phase change material.
Claim 17
Dependent Claim
20 words
The article of claim 12 or 13, wherein the agent capable of interacting exothermically with water includes a metal oxide.
Claim 18
Dependent Claim
17 words
The article of claim 12, wherein the agent capable of interacting exothermically with water includes calcium oxide.
Claim 19
Dependent Claim
18 words
The article of claim 12, wherein the agent capable of interacting exothermically with water includes anhydrous magnesium sulfate.
Claim 20
Dependent Claim
22 words
The article of claim 12 or 13, wherein the heat source includes at least two agents capable of interacting exothermically with water.
Claim 21
Dependent Claim
13 words
The article of claim 13, wherein the phase change material includes a sugar.
Claim 22
Dependent Claim
13 words
The article of claim 13, wherein the phase change material includes a wax.
Claim 23
Dependent Claim
14 words
The article of claim 12, wherein the drug is carried by a fibrous substrate.
Claim 24
Dependent Claim
13 words
The article of claim 12, wherein the dispersing agent has a granular form.
Claim 25
Dependent Claim
46 words
The article of claim 12 or 13, wherein the heat source is capable of heating a portion of the drug to a temperature in excess of about 70° C. within 20 seconds from the time that exothermic interaction of the chemical agent with water is initiated.
Claim 26
Dependent Claim
33 words
The article of claim 12 or 13, wherein the heat source is such that the drug is not heated to a temperature above about 350° C. during the life of the heat source.
Claim 27
Dependent Claim
33 words
The article of claim 12 or 13, wherein the heat source is such that the drug is not heated to a temperature above about 180° C. during the life of the heat source.
Claim 28
Dependent Claim
42 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and (ii) a phase change material.
Claim 29
Dependent Claim
42 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and (ii) a phase change material.
Claim 30
Dependent Claim
24 words
The article of claim 25, wherein the heat source further includes a third chemical agent capable of interacting exothermically with the first chemical agent.
Claim 31
Dependent Claim
20 words
The article of claim 25, wherein the phase change material has a solid form prior to use of the article.
Claim 32
Dependent Claim
20 words
The article of claim 26, wherein the phase change material has a solid form prior to use of the article.
Claim 33
Dependent Claim
14 words
The article of claim 25, wherein the drug is carried by a fibrous substrate.
Claim 34
Dependent Claim
44 words
The article of claim 25, wherein the heat source is capable of heating at least a portion of the drug to a temperature in excess of about 70° C. within 20 seconds from the time that exothermic interaction of the chemical agents is initiated.
Claim 35
Dependent Claim
44 words
The article of claim 25, wherein the heat source is capable of heating at least a portion of the drug to a temperature in excess of about 70° C within 10 seconds from the time that exothermic interaction of the chemical agents is initiated.
Claim 36
Dependent Claim
33 words
The article of claim 25 or 26, wherein the heat source is such that the drug is not heated to a temperature above about 350° C. during the life of the heat source.
Claim 37
Dependent Claim
33 words
The article of claim 25 or 26, wherein the heat source is such that the drug is not heated to a temperature above about 180° C. during the life of the heat source.
Claim 38
Dependent Claim
40 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) at least one chemical agent capable of interacting exothermically with water, and (ii) a phase change material.
Claim 39
Dependent Claim
40 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) at least one chemical agent capable of interacting exothermically with water, and (ii) a phase change material.
Claim 40
Dependent Claim
18 words
The article of claim 34, wherein the agent capable of interacting exothermically with water includes a metal oxide.
Claim 41
Dependent Claim
18 words
The article of claim 34, wherein the agent capable of interacting exothermically with water includes anhydrous magnesium sulfate.
Claim 42
Dependent Claim
20 words
The article of claim 34; wherein the heat source includes at least two agents capable of interacting exothermically with water.
Claim 43
Dependent Claim
14 words
The article of claim 34, wherein the drug is carried by a fibrous substrate.
Claim 44
Dependent Claim
44 words
The article of claim 34, wherein the heat source is capable of heating a portion of the drug to a temperature in excess of about 70° C. within 20 seconds from the time that exothermic interaction of the chemical agent with water is initiated.
Claim 45
Dependent Claim
31 words
The article of claim 34, wherein the heat source is such that the drug is not heated to a temperature above about 350° C. during the life of the heat source.
Claim 46
Dependent Claim
31 words
The article of claim 34, wherein the heat source is such that the drug is not heated to a temperature above about 180° C. during the life of the heat source.
Claim 47
Dependent Claim
91 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including: (i) a first chemical agent, (ii) a second chemical agent capable of interacting exothermically with the first chemical agent, (iii) a third chemical agent capable of interacting exothermically with the first chemical agent; the heat source being capable of heating at least a portion of the drug to at least about 70° C. within 20 seconds of initiation and to a maximum temperature of less than about 200° C.
Claim 48
Dependent Claim
91 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including: (i) a first chemical agent, (ii) a second chemical agent capable of interacting exothermically with the first chemical agent, (iii) a third chemical agent capable of interacting exothermically with the first chemical agent; the heat source being capable of heating at least a portion of the drug to at least about 70° C. within 20 seconds of initiation and to a maximum temperature of less than about 200° C.
Claim 49
Dependent Claim
42 words
The article of claim 42, wherein the heat source is capable of heating at least a portion of the drug to at least about 70° C. within 10 seconds of initiation and to a maximum temperature of less than about 180° C.
Claim 50
Dependent Claim
16 words
The article of claim 42 or 43, wherein the heat source further includes a dispersing agent.
Claim 51
Dependent Claim
71 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, the heat source including at least one chemical agent capable of interacting exothermically with water; the heat source being capable of heating at least a portion of the drug to at least about 70° C. within 20 seconds of initiation and to a maximum temperature of less than about 200° C.
Claim 52
Dependent Claim
71 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, the heat source including at least one chemical agent capable of interacting exothermically with water; the heat source being capable of heating at least a portion of the drug to at least about 70° C. within 20 seconds of initiation and to a maximum temperature of less than about 200° C.
Claim 53
Dependent Claim
42 words
The article of claim 45, wherein the heat source is capable of heating at least a portion of the drug to at least about 70° C. within 10 seconds of initiation and to a maximum temperature of less than about 180° C.
Claim 54
Dependent Claim
16 words
The article of claim 45 or 46, wherein the heat source further includes a dispersing agent.
Claim 55
Dependent Claim
70 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including: (i) first, second and third chemical agents capable of undergoing an exothermic chemical reaction with one another. (ii) a fourth agent capable of reacting with a reaction product of the exothermic chemical reaction to regenerate the second and third chemical agents for reaction with remaining first chemical agent.
Claim 56
Dependent Claim
70 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including: (i) first, second and third chemical agents capable of undergoing an exothermic chemical reaction with one another. (ii) a fourth agent capable of reacting with a reaction product of the exothermic chemical reaction to regenerate the second and third chemical agents for reaction with remaining first chemical agent.
Claim 57
Dependent Claim
34 words
The article of claim 48, wherein the first agent is magnesium and/or aluminum, the second agent is water, the third agent is sodium hydroxide, and the fourth agent is sodium nitrite and/or sodium nitrate.
Claim 58
Dependent Claim
25 words
The article of claim 49, wherein the amount of first agent and fourth agent per article ranges from about 50 mg to about 300 mg.
Claim 59
Dependent Claim
47 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and (ii) a normally solid dispersing agent for the first agent.
Claim 60
Dependent Claim
47 words
A drug delivery article comprising: (a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and (ii) a normally solid dispersing agent for the first agent.
Claim 61
Dependent Claim
13 words
The article of claim 51, wherein the dispersing agent has a granular form.
Claim 62
Dependent Claim
44 words
The article of claim 51, wherein the heat source is capable of heating at least a portion of the drug to a temperature in excess of about 70° C. within 20 seconds from the time that exothermic interaction of the chemical agents is initiated.
Claim 63
Dependent Claim
44 words
The article of claim 51, wherein the heat source is capable of heating at least a portion of the drug to a temperature in excess of about 70° C. within 10 seconds from the time that exothermic interaction of the chemical agents is initiated.
Claim 64
Dependent Claim
31 words
The article of claim 51, wherein the heat source is such that the drug is not heated to a temperature above about 350° C. during the life of the heat source.
Claim 65
Dependent Claim
31 words
The article of claim 51, wherein the heat source is such that the drug is not heated to a temperature above about 180° C. during the life of the heat source.
Claim 66
Dependent Claim
14 words
The article of claim 44, wherein the dispersing agent has a normally solid form.
Claim 67
Dependent Claim
14 words
The article of claim 47, wherein the dispersing agent has a normally solid form.
Claim 68
Dependent Claim
14 words
The article of claim 12, wherein the dispersing agent has a normally solid form.
Claim 69
Dependent Claim
29 words
The article of claim 1, 2 or 3, including a mouthend piece for delivering drug volatilized by the heat source to the mouth of the user of the article.
Claim 70
Dependent Claim
28 words
The article of claim 12 or 13, including a mouthend piece for delivering drug volatilized by the heat source to the mouth of the user of the article.
Claim 71
Dependent Claim
26 words
The article of claim 34 including a mouthend piece for delivering drug volatilized by the heat source to the mouth of the user of the article.
Claim 72
Dependent Claim
28 words
The article of claim 42 or 43, including a mouthend piece for delivering drug volatilized by the heat source to the mouth of the user of the article.
Claim 73
Dependent Claim
28 words
The article of claim 45 or 46, including a mouthend piece for delivering drug volatilized by the heat source to the mouth of the user of the article.
Claim 74
Dependent Claim
28 words
The article of claim 50 or 51, including a mouthend piece for delivering drug volatilized by the heat source to the mouth of the user of the article.
Claim 75
Dependent Claim
26 words
The article of claim 51, including a mouthend piece for delivering drug volatilized by the heat source to the mouth of the user of the article.
Claim 76
Dependent Claim
15 words
The article of claim 12, wherein the chemical agent and dispersing agent have solid forms.
Claim 77
Dependent Claim
18 words
The article of claim 13, wherein the chemical agent(s), dispersing agent and phase change material have solid forms.
Claim 78
Dependent Claim
16 words
The article of claim 34 wherein the chemical agent(s) and phase change material have solid forms.
Claim 79
Dependent Claim
26 words
The article of claim 44, including a mouthend piece for delivering drug volatilized by the heat source to the mouth of the user of the article.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-16 | 1993-10-16 | 1994-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-16 | 1997-10-16 | 1998-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-16 | 2001-10-16 | 2002-04-17 | $7700.00 | Window Closed / Lapsed |