US4916241A
Expired / Lapsed
US
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Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones
Assignee: Wyeth LLC
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Filing: 1988-06-06
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Granted: 1990-04-10
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Expires: 2008-06-06
Abstract
Abstract This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.
Inventors
- 👤 Marshall A. Hayward
- 👤 Joseph P. Sabatucci
- 👤 Ivo L. Jirkovsky
- 👤 Yvon Lefebvre
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:35
CPC Classifications
C; C07; C07D; C07D407/00; C07D407/02; C07D407/06; C07D307/00; C07D307/02; C07D307/34; C07D307/56; C07D307/60
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
58 words
The compounds of formula (I) ##STR4## wherein X is hydroxy; Y is lower alkyl containing 1 to 6 carbon atoms; A 1 and A 2 are independently selected from the group consisting of phenyl, OR, OAr or halogen wherein R is lower alkyl containing 1 to 6 carbon atoms or A 1 A 2 represents --OCH 2 O--.
Claim 2
Dependent Claim
58 words
The compounds of formula (I) ##STR4## wherein X is hydroxy; Y is lower alkyl containing 1 to 6 carbon atoms; A 1 and A 2 are independently selected from the group consisting of phenyl, OR, OAr or halogen wherein R is lower alkyl containing 1 to 6 carbon atoms or A 1 A 2 represents --OCH 2 O--.
Claim 3
Dependent Claim
53 words
The compounds according to claim 1 wherein X is hydroxy; Y is --CH 3 ; A 1 and A 2 are independently selected from the group consisting of phenyl, OR, OAr or halogen wherein R is lower alkyl containing 1 to 6 carbon atoms or A 1 A 2 represents --OCH 2 O--.
Claim 4
Dependent Claim
8 words
The compound according to claim 2 designated 4-[1-([1,1'-biphenyl]-4-yl)-1-hydroxyethyl]-5-hydroxy-2(5H)-furanone.
Claim 5
Dependent Claim
8 words
The compound according to claim 2 designated 5-hydroxy-4-[1-hydroxy-1-[3,4-[methylenedioxyphenyl]ethyl]-2(5H)-furanone.
Claim 6
Dependent Claim
8 words
The compound according to claim 2 designated 5-hydroxy-4-[1-hydroxy-1-(4-phenoxyphenyl)ethyl-2(5H)-furanone.
Claim 7
Dependent Claim
8 words
The compound according to claim 2 designated 5-hydroxy-4-[1-hydroxy-1-[3,4-dimethoxyphenyl]ethyl]-2(5H)-furanone.
Claim 8
Dependent Claim
8 words
The compound according to claim 2 designated 5-hydroxy-4-[1-hydroxy-1-[4-methoxy-3-bromophenyl]ethyl]-2(5H)-furanone.
Claim 9
Dependent Claim
8 words
The compound according to claim 2 designated 5-hydroxy-4-[1-hydroxy-1-[4-chlorophenyl]-2(5H)-furanone.
Claim 10
Dependent Claim
105 words
A pharmaceutical composition useful for modifying the balance between the rate of bone resorption and the rate of bone formation in a host animal whereby the ratio of said rate of bone resorption to said rate of bone formation is reduced, comprising a compound of formula (I) ##STR5## wherein X is hydroxy; Y is lower alkyl containing 1 to 6 carbon atoms; A 1 and A 2 are independently selected from the group consisting of phenyl, OR, OAr or halogen wherein R is lower alkyl containing 1 to 6 carbon atoms or A 1 A 2 represents --OCH 2 O-- and a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
105 words
A pharmaceutical composition useful for modifying the balance between the rate of bone resorption and the rate of bone formation in a host animal whereby the ratio of said rate of bone resorption to said rate of bone formation is reduced, comprising a compound of formula (I) ##STR5## wherein X is hydroxy; Y is lower alkyl containing 1 to 6 carbon atoms; A 1 and A 2 are independently selected from the group consisting of phenyl, OR, OAr or halogen wherein R is lower alkyl containing 1 to 6 carbon atoms or A 1 A 2 represents --OCH 2 O-- and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-04-09 | 1993-10-09 | 1994-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-09 | 1997-10-09 | 1998-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-09 | 2001-10-09 | 2002-04-10 | $7700.00 | Window Closed / Lapsed |