US4915102A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hinged dermal applicator
Assignee: Mylan Technologies Inc
•
Filing: 1988-09-01
•
Granted: 1990-04-10
•
Expires: 2008-09-01
Abstract
Abstract Devices for applying film layers and/or active agent carriers to the skin are disclosed, including a liner layer having a release surface, a carrier layer for the film layer, a first adhesive between the carrier layer and the film layer, and a second adhesive between the liner layer and the opposite surface of the film layer and carrier layer. In this manner, the film layer is sandwiched between the liner layer and carrier layer, and the coefficients of adhesion of the two adhesives are selected so that upon separation of the liner layer and the carrier layer the film layer remains on the carrier layer, and upon application of the film layer to the skin, the film layer transfers from the carrier layer to the skin. The device preferably includes a hinge permanently connecting a peripheral edge of the carrier layer to the liner layer in order to facilitate this process, and in a preferred embodiment an active agent carrier is either substituted for or added to the film layer.
Inventors
- 👤 Alfred Kwiatek
- 👤 John J. Wick
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 15:32
CPC Classifications
A; A61; A61F; A61F13/00; A61F13/02; A61F13/023; A61F2013/00361; A61F2013/00655; A61F2013/00714; A61F2013/00727; A61F2013/00761; A61F2013/00795; A61F2013/008; A61F2013/00817; A61F2013/00821; A61F2013/00829; A61F2013/00846; A61F2013/00855; A61F2013/00868; A61F2013/00902; A61F2013/00906; A61F13/0276; A61F2013/0296
Claims Analysis
Total Claims: 162
Claim 1
Independent Claim
308 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer, said carrier layer including a first surface and a second surface, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said film layer being located on said first surface of said carrier layer at a location displaced from said hinge means, first adhesive means interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said portion of said carrier layer other than said hinge means is separated from said liner layer, and second adhesive means interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer, for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said film layer, said first adhesive means having a first coefficient of adhesion and said second adhesive means having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive means therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 2
Independent Claim
308 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer, said carrier layer including a first surface and a second surface, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said film layer being located on said first surface of said carrier layer at a location displaced from said hinge means, first adhesive means interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said portion of said carrier layer other than said hinge means is separated from said liner layer, and second adhesive means interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer, for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said film layer, said first adhesive means having a first coefficient of adhesion and said second adhesive means having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive means therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 3
Dependent Claim
24 words
The device of claim 1 wherein said second adhesive means comprises an adhesive layer covering at least the entire surface of said film layer.
Claim 4
Dependent Claim
22 words
The device of claim 1 wherein said predetermined location comprises a peripheral edge portion of said liner layer and said carrier layer.
Claim 5
Dependent Claim
45 words
The device of claim 1 wherein said hinge means comprises a portion of said liner layer corresponding to said predetermined location being free of said releasable surface, and including adhesive hinge means interposed between said liner layer and said carrier layer at said predetermined location.
Claim 6
Dependent Claim
13 words
The device of claim 1 wherein said releasable surface comprises a siliconized coating.
Claim 7
Dependent Claim
23 words
The device of claim 1 wherein said liner layer is selected from the group consisting of paper, a thermoplastic, foil, and mixtures thereof.
Claim 8
Dependent Claim
29 words
The device of claim 1 wherein a portion of said first surface of said carrier layer in contact with said film layer is free of said first adhesive layer.
Claim 9
Dependent Claim
27 words
The device of claim 1 wherein said carrier layer is selected from the group consisting of polyethylene, polypropylene, polyvinylidene chloride, polyethylene terephthalate, polyesters, polyamides, and mixtures thereof.
Claim 10
Dependent Claim
11 words
The device of claim 8 wherein said carrier layer comprises polyethylene.
Claim 11
Dependent Claim
23 words
The device of claim 1 wherein said film layer is selected from the group consisting of polyether block amides, thermoplastic polyurethanes, and polyesters.
Claim 12
Dependent Claim
25 words
The device of claim 1 including removal means for separating said portion of said carrier layer other than said hinge means from said liner layer.
Claim 13
Dependent Claim
37 words
The device of claim 11 wherein said removal means comprises an extended portion of said carrier layer extending beyond the edge of said liner layer whereby said extended portion of said carrier layer can be grasped thereby.
Claim 14
Dependent Claim
33 words
The device of claim 11 wherein said removal means comprises slit means in said liner layer whereby said liner layer can be grasped at said slit means and separated from said carrier layer.
Claim 15
Dependent Claim
57 words
The device of claim 1 wherein said removal means comprises a predetermined peripheral portion of said liner layer being free of said second adhesive layer whereby said liner layer and said carrier layer are not adhesively secured to each other at said predetermined peripheral location and said liner layer and said carrier layer can be grasped therebetween.
Claim 16
Independent Claim
281 words
A device for applying an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said active agent carrier, said carrier layer including a first surface and a second surface, said active agent carrier being located on said first surface of said carrier layer, first adhesive means interposed between said first surface of said carrier layer and said active agent carrier for maintaining said active agent carrier in contact with said carrier layer when said carrier layer is separated from said liner layer, and second adhesive means interposed between said first surface of said liner layer and said first surface of said carrier layer including said active agent carrier, for releasably maintaining said first surface of said carrier layer including said active agent carrier in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said active agent carrier, said first adhesive means having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said active agent carrier being less than said second coefficient of adhesion of said active agent carrier to said skin or mucosa of said patient, whereby upon application of said active agent carrier to said skin or mucosa of said patient with said second adhesive means therebetween, said active agent carrier adheres to said skin or mucosa of said patient and said active agent carrier can thereby be removed from said carrier layer.
Claim 17
Independent Claim
281 words
A device for applying an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said active agent carrier, said carrier layer including a first surface and a second surface, said active agent carrier being located on said first surface of said carrier layer, first adhesive means interposed between said first surface of said carrier layer and said active agent carrier for maintaining said active agent carrier in contact with said carrier layer when said carrier layer is separated from said liner layer, and second adhesive means interposed between said first surface of said liner layer and said first surface of said carrier layer including said active agent carrier, for releasably maintaining said first surface of said carrier layer including said active agent carrier in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said active agent carrier, said first adhesive means having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said active agent carrier being less than said second coefficient of adhesion of said active agent carrier to said skin or mucosa of said patient, whereby upon application of said active agent carrier to said skin or mucosa of said patient with said second adhesive means therebetween, said active agent carrier adheres to said skin or mucosa of said patient and said active agent carrier can thereby be removed from said carrier layer.
Claim 18
Dependent Claim
83 words
The device of claim 15 wherein said first active agent carrier comprises a reservoir containing said active agent, release means for the controlled release of said active agent from said reservoir, and an active agent impermeable barrier layer between said reservoir and said carrier layer, whereby said active agent may only be released from the inner surface of said reservoir towards said skin or mucosa of said patient upon application of said active agent carrier to said skin or mucosa of said patient.
Claim 19
Dependent Claim
44 words
The device of claim 16 wherein said release means comprises an active agent permeable membrane layer formed on said inner surface of said reservoir, whereby said reservoir is completely enclosed between said active agent permeable membrane layer and said active agent impermeable barrier layer.
Claim 20
Dependent Claim
37 words
The device of claim 17 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 21
Dependent Claim
60 words
The device of claim 18 wherein said second adhesive means includes an active agent permeable adhesive portion and an active agent impermeable adhesive portion, said active agent permeable adhesive portion corresponding to said active agent permeable membrane layer and said active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 22
Dependent Claim
25 words
The device of claim 16 wherein said release means comprises a plurality of micro-capsules containing said active agent encapsulated by an active agent permeable membrane.
Claim 23
Dependent Claim
25 words
The device of claim 20 wherein said second adhesive means includes an active agent permeable adhesive portion corresponding to said inner surface of said reservoir.
Claim 24
Dependent Claim
86 words
The device of claim 19 wherein said active agent permeable membrane layer extends peripherally beyond said reservoir so as to provide at least a portion of overlapping peripheral surfaces between said peripheral portion of said active agent permeable membrane layer and said peripheral portion of said active agent impermeable barrier layer, and wherein said overlapping peripheral portions are heat sealed together to create an active agent impermeable seal surrounding said reservoir, whereby said active agent impermeable adhesive means is applied to said active agent impermeable seal.
Claim 25
Independent Claim
321 words
A device for applying an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said active agent carrier, said carrier layer including a first surface and a second surface, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said active agent carrier being located on said first surface of said carrier layer at a location displaced from said hinge means, first adhesive means interposed between said first surface of said carrier layer and said active agent carrier for maintaining said active agent carrier in contact with said carrier layer when said portion of said carrier layer other than said hinge means is separated from said liner layer, and second adhesive means interposed between said first surface of said liner layer and said first surface of said carrier layer including said active agent carrier, for releasably maintaining said first surface of said carrier layer including said active agent carrier in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said active agent carrier, said first adhesive means having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said active agent carrier being less than said second coefficient of adhesion of said active agent carrier to said skin or mucosa of said patient, whereby upon application of said active agent carrier to said skin or mucosa of said patient with said second adhesive means therebetween, said active agent carrier adheres to said skin or mucosa of said patient and said active agent carrier can thereby be removed from said carrier layer.
Claim 26
Independent Claim
321 words
A device for applying an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said active agent carrier, said carrier layer including a first surface and a second surface, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said active agent carrier being located on said first surface of said carrier layer at a location displaced from said hinge means, first adhesive means interposed between said first surface of said carrier layer and said active agent carrier for maintaining said active agent carrier in contact with said carrier layer when said portion of said carrier layer other than said hinge means is separated from said liner layer, and second adhesive means interposed between said first surface of said liner layer and said first surface of said carrier layer including said active agent carrier, for releasably maintaining said first surface of said carrier layer including said active agent carrier in contact with said first surface of said liner layer, said second adhesive means covering at least the entire periphery of said active agent carrier, said first adhesive means having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said active agent carrier being less than said second coefficient of adhesion of said active agent carrier to said skin or mucosa of said patient, whereby upon application of said active agent carrier to said skin or mucosa of said patient with said second adhesive means therebetween, said active agent carrier adheres to said skin or mucosa of said patient and said active agent carrier can thereby be removed from said carrier layer.
Claim 27
Dependent Claim
83 words
The device of claim 23 wherein said first active agent carrier comprises a reservoir containing said active agent, release means for the controlled release of said active agent from said reservoir, and an active agent impermeable barrier layer between said reservoir and said carrier layer, whereby said active agent may only be released from the inner surface of said reservoir towards said skin or mucosa of said patient upon application of said active agent carrier to said skin or mucosa of said patient.
Claim 28
Dependent Claim
44 words
The device of claim 24 wherein said release means comprises an active agent permeable membrane layer formed on said inner surface of said reservoir, whereby said reservoir is completely enclosed between said active agent permeable membrane layer and said active agent impermeable barrier layer.
Claim 29
Dependent Claim
37 words
The device of claim 25 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 30
Dependent Claim
60 words
The device of claim 26 wherein said second adhesive means includes an active agent permeable adhesive portion and an active agent impermeable adhesive portion, said active agent permeable adhesive portion corresponding to said active agent permeable membrane layer and said active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 31
Dependent Claim
25 words
The device of claim 24 wherein said release means comprises a plurality of micro-capsules containing said active agent encapsulated by an active agent permeable membrane.
Claim 32
Dependent Claim
25 words
The device of claim 28 wherein said second adhesive means includes an active agent permeable adhesive portion corresponding to said inner surface of said reservoir.
Claim 33
Dependent Claim
86 words
The device of claim 27 wherein said active agent permeable membrane layer extends peripherally beyond said reservoir so as to provide at least a portion of overlapping peripheral surfaces between said peripheral portion of said active agent permeable membrane layer and said peripheral portion of said active agent impermeable barrier layer, and wherein said overlapping peripheral portions are heat sealed together to create an active agent impermeable seal surrounding said reservoir, whereby said active agent impermeable adhesive means is applied to said active agent impermeable seal.
Claim 34
Dependent Claim
30 words
The device of claim 27 wherein said active agent impermeable adhesive layer comprises an adhesive composition selected from the group consisting of natural rubber adhesive, acrylic adhesives, and synthetic adhesives.
Claim 35
Dependent Claim
119 words
The device of claim 27 wherein said active agent permeable adhesive layer comprises an adhesive selected from the group consisting of acrylate and methacrylate resins; copolymers of acrylate or methacrylate, esters with acrylic acid, methacrylic acid, acrylamide, methacrylamides, N-alkoxymethyl acrylamides, N-alkoxymethyl methacrylamides, N-t-butylacrylamide, itaconic acid, vinyl acetate, N-branched alkyl maleamic acids wherein the alkyl group has 10 to 24 carbon atoms, glycol diacrylates, or mixture of these monomers; silicon rubber; styrenebutadiene rubber; butyl-ether rubber; neoprene rubber; nitrile rubber; polyisobutylene; polybutadiene; polyisoprene; polyurethane elastomers; polyvinyl alcohol; polyvinyl ethers; polyvinyl pyrrolidone; polyvinyl acetate; ureaformaldehyde resins; phenol formaldehyde resins; resorcinal formaldehyde resins; ethyl cellulose; methyl cellulose; nitrocellulose; cellulose acetate-butyrate; carboxymethyl cellulose; guar gum; acacia gum; pectina gum; starch; destria; gelatin; and casein.
Claim 36
Dependent Claim
31 words
The device of claim 25 wherein said active agent permeable membrane layer comprises a material selected from the group consisting of polypropylene, polycarbonates, polyvinyl chloride, cellulose acetate, cellulose nitrate and polyacrylonitrile.
Claim 37
Dependent Claim
46 words
The device of claim 23 wherein said active agent impermeable barrier layer comprises a material selected from the group consisting of cellophane, cellulose acetate, ethyl cellulose, plasticized vinyl acetate-vinyl chloride copolymers, ethylene-vinyl acetate copolymer, polyethylene terephthalate, nylon, polyethylene, polypropylene, polyvinylidene chloride, paper, cloth and aluminum foil.
Claim 38
Dependent Claim
20 words
The device of claim 23 wherein said active agent is selected from the group consisting of scopolamine, nitroglycerine and estradiol.
Claim 39
Independent Claim
338 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer and said active agent carrier, said carrier layer including a first surface and a second surface, said film layer including a first surface and a second surface, said first surface of said film layer being located on said first surface of said carrier layer, a first adhesive layer interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said carrier layer is separated from said liner layer, said active agent carrier being located on said second surface of said film layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier, for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active, agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can be simultaneously removed from said carrier layer.
Claim 40
Independent Claim
338 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer and said active agent carrier, said carrier layer including a first surface and a second surface, said film layer including a first surface and a second surface, said first surface of said film layer being located on said first surface of said carrier layer, a first adhesive layer interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said carrier layer is separated from said liner layer, said active agent carrier being located on said second surface of said film layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier, for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active, agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can be simultaneously removed from said carrier layer.
Claim 41
Dependent Claim
82 words
The device of claim 36 wherein said active agent carrier comprises a reservoir containing said active agent, release means for the controlled release of said active agent from said reservoir, and an active agent impermeable barrier layer between said reservoir and said film layer, whereby said active agent may only be released from the inner surface of said reservoir towards said skin or mucosa of said patient upon application of said active agent carrier to said skin or mucosa of said patient.
Claim 42
Dependent Claim
44 words
The device of claim 37 wherein said release means comprises an active agent permeable membrane layer formed on said inner surface of said reservoir, whereby said reservoir is completely enclosed between said active agent permeable membrane layer and said active agent impermeable barrier layer.
Claim 43
Dependent Claim
37 words
The device of claim 38 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 44
Dependent Claim
60 words
The device of claim 39 wherein said second adhesive layer includes an active agent permeable adhesive portion and an active agent impermeable adhesive portion, said active agent permeable adhesive portion corresponding to said active agent permeable membrane layer and said active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 45
Dependent Claim
25 words
The device of claim 37 wherein said release means comprises a plurality of micro-capsules containing said active agent encapsulated by an active agent permeable membrane.
Claim 46
Dependent Claim
25 words
The device of claim 41 wherein said second adhesive layer includes an active agent permeable adhesive portion corresponding to said inner surface of said reservoir.
Claim 47
Dependent Claim
37 words
The device of claim 42 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 48
Dependent Claim
32 words
The device of claim 43 wherein said second adhesive layer includes an active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 49
Dependent Claim
44 words
The device of claim 40 wherein said active agent impermeable barrier layer comprises a cover layer including an inner surface and an outer surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 50
Dependent Claim
50 words
The device of claim 37 wherein said active agent impermeable barrier layer includes an inner surface facing said reservoir, and an outer surface facing said film layer, and a backing member disposed on said portion of said inner surface of said active agent impermeable barrier layer corresponding to said reservoir.
Claim 51
Dependent Claim
86 words
The device of claim 40 wherein said active agent permeable membrane layer extends peripherally beyond said reservoir so as to provide at least a portion of overlapping peripheral surfaces between said peripheral portion of said active agent permeable membrane layer and said peripheral portion of said active agent impermeable barrier layer, and wherein said overlapping peripheral portions are heat sealed together to create an active agent impermeable seal surrounding said reservoir, whereby said active agent impermeable adhesive layer is applied to said active agent impermeable seal.
Claim 52
Dependent Claim
44 words
The device of claim 44 wherein said active agent impermeable barrier layer comprises a cover layer including an outer surface and an inner surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 53
Independent Claim
378 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer and said active agent carrier, said carrier layer including a first surface and a second surface, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said film layer including a first surface and a second surface, said first surface of said film layer being located on said first surface of said carrier layer at a location displaced from said hinge means, a first adhesive layer interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said portion of said carrier layer other than said hinge means is separated from said liner layer, said active agent carrier being located on said second surface of said film layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier, for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can be simultaneously removed from aid carrier layer.
Claim 54
Independent Claim
378 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer and said active agent carrier, said carrier layer including a first surface and a second surface, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location thereon, said film layer including a first surface and a second surface, said first surface of said film layer being located on said first surface of said carrier layer at a location displaced from said hinge means, a first adhesive layer interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said portion of said carrier layer other than said hinge means is separated from said liner layer, said active agent carrier being located on said second surface of said film layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier, for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can be simultaneously removed from aid carrier layer.
Claim 55
Dependent Claim
82 words
The device of claim 49 wherein said active agent carrier comprises a reservoir containing said active agent, release means for the controlled release of said active agent from said reservoir, and an active agent impermeable barrier layer between said reservoir and said film layer, whereby said active agent may only be released from the inner surface of said reservoir towards said skin or mucosa of said patient upon application of said active agent carrier to said skin or mucosa of said patient.
Claim 56
Dependent Claim
44 words
The device of claim 50 wherein said release means comprises an active agent permeable membrane layer formed on said inner surface of said reservoir, whereby said reservoir is completely enclosed between said active agent permeable membrane layer and said active agent impermeable barrier layer.
Claim 57
Dependent Claim
37 words
The device of claim 51 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 58
Dependent Claim
60 words
The device of claim 52 wherein said second adhesive layer includes an active agent permeable adhesive portion and an active agent impermeable adhesive portion, said active agent permeable adhesive portion corresponding to said active agent permeable membrane layer and said active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 59
Dependent Claim
25 words
The device of claim 50 wherein said release means comprises a plurality of micro-capsules containing said active agent encapsulated by an active agent permeable membrane.
Claim 60
Dependent Claim
25 words
The device of claim 54 wherein said second adhesive layer includes an active agent permeable adhesive portion corresponding to said inner surface of said reservoir.
Claim 61
Dependent Claim
37 words
The device of claim 55 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 62
Dependent Claim
32 words
The device of claim 56 wherein said second adhesive layer includes an active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 63
Dependent Claim
44 words
The device of claim 53 wherein said active agent impermeable barrier layer comprises a cover layer including an inner surface and an outer surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 64
Dependent Claim
50 words
The device of claim 50 wherein said active agent impermeable barrier layer includes an inner surface facing said reservoir, and an outer surface facing said film layer, and a backing member disposed on said portion of said inner surface of said active agent impermeable barrier layer corresponding to said reservoir.
Claim 65
Dependent Claim
86 words
The device of claim 53 wherein said active agent permeable membrane layer extends peripherally beyond said reservoir so as to provide at least a portion of overlapping peripheral surfaces between said peripheral portion of said active agent permeable membrane layer and said peripheral portion of said active agent impermeable barrier layer, and wherein said overlapping peripheral portions are heat sealed together to create an active agent impermeable seal surrounding said reservoir, whereby said active agent impermeable adhesive layer is applied to said active agent impermeable seal.
Claim 66
Dependent Claim
30 words
The device of claim 53 wherein said active agent impermeable adhesive layer comprises an adhesive composition selected from the group consisting of natural rubber adhesive, acrylic adhesives, and synthetic adhesives.
Claim 67
Dependent Claim
119 words
The device of claim 53 wherein said active agent permeable adhesive layer comprises an adhesive selected from the group consisting of acrylate and methacrylate resins; copolymers of acrylate or methacrylate, esters with acrylic acid, methacrylic acid, acrylamide, methacrylamides, N-alkoxymethyl acrylamides, N-alkoxymethyl methacrylamides, N-t-butylacrylamide, itaconic acid, vinyl acetate, N-branched alkyl maleamic acids wherein the alkyl group has 10 to 24 carbon atoms, glycol diacrylates, or mixture of these monomers; silicon rubber; styrenebutadiene rubber; butyl-ether rubber; neoprene rubber; nitrile rubber; polyisobutylene; polybutadiene; polyisoprene; polyurethane elastomers; polyvinyl alcohol; polyvinyl ethers; polyvinyl pyrrolidone; polyvinyl acetate; ureaformaldehyde resins; phenol formaldehyde resins; resorcinal formaldehyde resins; ethyl cellulose; methyl cellulose; nitrocellulose; cellulose acetate-butyrate; carboxymethyl cellulose; guar gum; acacia gum; pectina gum; starch; destria; gelatin; and casein.
Claim 68
Dependent Claim
31 words
The device of claim 51 wherein said active agent permeable membrane layer comprises a material selected from the group consisting of polypropylene, polycarbonates, polyvinyl chloride, cellulose acetate, cellulose nitrate and polyacrylonitrile.
Claim 69
Dependent Claim
46 words
The device of claim 49 wherein said active agent impermeable barrier layer comprises a material selected from the group consisting of cellophane, cellulose acetate, ethyl cellulose, plasticized vinyl acetate-vinyl chloride copolymers, ethylene-vinyl acetate copolymer, polyethylene terephthalate, nylon, polyethylene, polypropylene, polyvinylidene chloride, paper, cloth and aluminum foil.
Claim 70
Dependent Claim
30 words
The device of claim 58 wherein said cover layer is selected from the group consisting of a film of polyethylene terephthalate on polyethylene or a polyethylene/metallized polyethylene terephthalate/ polyethylene laminate.
Claim 71
Dependent Claim
20 words
The device of claim 49 wherein said active agent is selected from the group consisting of scopolamine, nitroglycerine and estradiol.
Claim 72
Dependent Claim
44 words
The device of claim 57 wherein said active agent impermeable barrier layer comprises a cover layer including an outer surface and an inner surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 73
Dependent Claim
30 words
The device of claim 61 wherein said active agent impermeable adhesive layer comprises an adhesive composition selected from the group consisting of natural rubber adhesives, acrylic adhesives, and synthetic adhesives.
Claim 74
Dependent Claim
119 words
The device of claim 57 wherein said active agent permeable adhesive layer comprises an adhesive selected from the group consisting of acrylate and methacrylate resins; copolymers of acrylate or methacrylate esters with acrylic acid, methacrylic acid, acrylamide, methacrylamides, N-alkoxymethyl acrylamides, N-alkoxymethyl methacrylamides, N-t-butylacrylamide, itaconic acid, vinylacetate, N-branched N-branched alkyl maleamic acids wherein the alkyl group has 10 to 24 carbon atoms, glycol diacrylates, or mixture of these monomers; silicon rubber; styrene-butadiene rubber; butyl-ether rubber; neoprene rubber; nitrile rubber; polyisobutylene; polybutadiene; polyisoprene; polyurethane elastomers; polyvinyl alcohol; polyvinyl ethers; polyvinyl pyrrolidone; polyvinyl acetate; ureaformaldehyde resins; phenol formaldehyde resins; resorcinal formaldehyde resins; ethyl cellulose; methyl cellulose; nitrocellulose; cellulose acetate-butyrate; carboxymethyl cellulose; guar gum; acacia gum; pectina gum; starch; destria; gelatin; and casein.
Claim 75
Dependent Claim
77 words
The device of claim 50 wherein said active agent permeable membrane layer is selected from the group consisting of polyvinyl chloride either unplasticized or plasticized with long-chain fatty amides, plasticized nylon, unplasticized soft nylon, silicone rubber, polyethylene, polyethylene terephthalate, polymerized esters of acrylic and methacrylic acid, modified collagent, cross-linked hydrophilic polyether gels, cross-linked polyvinyl alcohol, cross-linked partially hydrolyzed polyvinyl acetate, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, acacia gum, carboxymethyl cellulose, and carageenan alone or combined with gelatin.
Claim 76
Dependent Claim
30 words
The device of claim 48 wherein said cover layer is selected from the group consisting of a film of polyethylene terephthalate or polyethylene or a polyethylene/metallized polyethylene terephthalate/ polyethylene laminate.
Claim 77
Independent Claim
368 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, said film layer being located on said first surface of said carrier layer, temporary closure means for temporarily sealing said first surface of said liner layer to said first surface of said carrier layer at at least a portion of the corresponding outer peripheries thereof so as to provide a sealed container for said film layer therein, said temporary closure means comprising a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer, a first adhesive layer interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said carrier layer is separated from said liner layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said film layer in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 78
Independent Claim
368 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, said film layer being located on said first surface of said carrier layer, temporary closure means for temporarily sealing said first surface of said liner layer to said first surface of said carrier layer at at least a portion of the corresponding outer peripheries thereof so as to provide a sealed container for said film layer therein, said temporary closure means comprising a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer, a first adhesive layer interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said carrier layer is separated from said liner layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said film layer in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 79
Dependent Claim
50 words
The device of claim 72 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer, and wherein said first and second polymer layers comprise different polymers whereby said peelable heat seal is formed therebetween.
Claim 80
Dependent Claim
13 words
The device of claim 72 wherein said releasable surface comprises a siliconized coating.
Claim 81
Dependent Claim
31 words
The device of claim 74 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer.
Claim 82
Dependent Claim
16 words
The device of claim 75 wherein said first and second polymer layers comprise the same polymer.
Claim 83
Dependent Claim
53 words
The device of claim 72 wherein said first surface of said liner layer comprises a first polymer layer, said second surface of said liner layer comprises a paper layer, and said liner layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 84
Dependent Claim
53 words
The device of claim 77 wherein said first surface of said carrier layer comprises a first polymer layer, said second surface of said carrier layer comprises a paper layer, and said carrier layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 85
Dependent Claim
32 words
The device of claim 78 wherein said temporary closure means comprises a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer.
Claim 86
Dependent Claim
57 words
The device of claim 79 wherein said first surface of said carrier layer comprises a first polymer layer, said second surface of said carrier layer comprises a paper layer, and said carrier layer includes an intermediate layer between said first surface and said second surface of the carrier layer, said intermediate layer comprising a metallized film layer.
Claim 87
Independent Claim
389 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location comprising a portion of said corresponding outer peripheries thereof, said film layer being located on said first surface of said carrier layer at a location displaced from said hinge means, temporary closure means for temporarily sealing said first surface of said liner layer to said first surface of said carrier layer at the remaining portion of said corresponding outer peripheries thereof so as to provide a sealed container for said film layer therein, a first adhesive layer interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said portion of said carrier layer other than said hinge means is separated from said liner layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said film layer in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 88
Independent Claim
389 words
A device for applying a film layer to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location comprising a portion of said corresponding outer peripheries thereof, said film layer being located on said first surface of said carrier layer at a location displaced from said hinge means, temporary closure means for temporarily sealing said first surface of said liner layer to said first surface of said carrier layer at the remaining portion of said corresponding outer peripheries thereof so as to provide a sealed container for said film layer therein, a first adhesive layer interposed between said first surface of said carrier layer and said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said portion of said carrier layer other than said hinge means is separated from said liner layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer for releasably maintaining said first surface of said carrier layer including said film layer in contact with said first surface of said film layer in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer adheres to said skin or mucosa of said patient and said film layer can simultaneously be removed from said carrier layer.
Claim 89
Dependent Claim
32 words
The device of claim 81 wherein said temporary closure means comprises a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer.
Claim 90
Dependent Claim
50 words
The device of claim 82 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer, and wherein said first and second polymer layers comprise different polymers whereby said peelable heat seal is formed therebetween.
Claim 91
Dependent Claim
13 words
The device of claim 82 wherein said releasable surface comprises a siliconized coating.
Claim 92
Dependent Claim
31 words
The device of claim 84 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer.
Claim 93
Dependent Claim
16 words
The device of claim 85 wherein said first and second polymer layers comprise the same polymer.
Claim 94
Dependent Claim
53 words
The device of claim 82 wherein said first surface of said liner layer comprises a first polymer layer, said second surface of said liner layer comprises a paper layer, and said liner layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 95
Dependent Claim
53 words
The device of claim 87 wherein said first surface of said carrier layer comprises a first polymer layer, said second surface of said carrier layer comprises a paper layer, and said carrier layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 96
Dependent Claim
32 words
The device of claim 88 wherein said temporary closure means comprises a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer.
Claim 97
Dependent Claim
52 words
The device of claim 89 wherein said liner layer and said carrier layer each has a substantially square configuration, wherein said predetermined location for said hinge means comprises a first side of said square, and wherein said temporary closure means is located at the second, third and fourth sides of said square.
Claim 98
Dependent Claim
49 words
The device of claim 90 wherein said first surface of said liner layer comprises a first polymer layer and said second surface of said carrier layer comprises a second polymer layer, and said first and second polymer layers comprise different polymers whereby said peelable heat seal is formed therebetween.
Claim 99
Dependent Claim
13 words
The device of claim 90 wherein said releasable surface comprises a siliconized coating.
Claim 100
Dependent Claim
31 words
The device of claim 92 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer.
Claim 101
Dependent Claim
16 words
The device of claim 93 wherein said first and second polymer layers comprise the same polymer.
Claim 102
Dependent Claim
53 words
The device of claim 90 wherein said first surface of said liner layer comprises a first polymer layer, said second surface of said liner layer comprises a paper layer, and said liner layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 103
Dependent Claim
57 words
The device of claim 89 wherein said first surface of said carrier layer comprises a first polymer layer, said second surface of said carrier layer comprises a paper layer, and said carrier layer includes an intermediate layer between said first surface and said second surface of the carrier layer, said intermediate layer comprising a metallized film layer.
Claim 104
Independent Claim
408 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer and said active agent carrier, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, said film layer including a first surface and a second surface, and said first surface of said film layer being located on said first surface of said carrier layer, temporary closure means for temporarily sealing said first surface of said liner layer to said first surface of said liner layer to said first surface of said carrier layer at at least a portion of said corresponding outer peripheries thereof, so as to provide a sealed container for said film layer and said active agent carrier therein, a first adhesive layer interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said portion of said carrier layer other than said hinge means is separated from said liner layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can simultaneously be removed from said carrier layer.
Claim 105
Independent Claim
408 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer and said active agent carrier, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, said film layer including a first surface and a second surface, and said first surface of said film layer being located on said first surface of said carrier layer, temporary closure means for temporarily sealing said first surface of said liner layer to said first surface of said liner layer to said first surface of said carrier layer at at least a portion of said corresponding outer peripheries thereof, so as to provide a sealed container for said film layer and said active agent carrier therein, a first adhesive layer interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said portion of said carrier layer other than said hinge means is separated from said liner layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can simultaneously be removed from said carrier layer.
Claim 106
Dependent Claim
86 words
The device of claim 97 wherein said active agent carrier comprises a reservoir containing said active agent, release means for the controlled release of said active agent from said reservoir, and an active agent impermeable barrier layer between said reservoir and said film layer, whereby said active agent may only be released from the inner surface of said reservoir towards said skin or mucosa of said patient upon application of said film layer and said active agent carrier to said skin or mucosa of said patient.
Claim 107
Dependent Claim
44 words
The device of claim 98 wherein said release means comprises an active agent permeable membrane layer formed on said inner surface of said reservoir, whereby said reservoir is completely enclosed between said active agent permeable membrane layer and said active agent impermeable barrier layer.
Claim 108
Dependent Claim
37 words
The device of claim 99 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 109
Dependent Claim
60 words
The device of claim 100 wherein said second adhesive layer includes an active agent permeable adhesive portion and an active agent impermeable adhesive portion, said active agent permeable adhesive portion corresponding to said active agent permeable membrane layer and said active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 110
Dependent Claim
25 words
The device of claim 98 wherein said release means comprises a plurality of micro-capsules containing said active agent encapsulated by an active agent permeable membrane.
Claim 111
Dependent Claim
25 words
The device of claim 102 wherein said second adhesive layer includes an active agent permeable adhesive portion corresponding to said inner surface of said reservoir.
Claim 112
Dependent Claim
37 words
The device of claim 103 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 113
Dependent Claim
32 words
The device of claim 104 wherein said second adhesive layer includes an active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 114
Dependent Claim
44 words
The device of claim 101 wherein said active agent impermeable barrier layer comprises a cover layer including an inner surface and an outer surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 115
Dependent Claim
86 words
The device of claim 101 wherein said active agent permeable membrane layer extends peripherally beyond said reservoir so as to provide at least a portion of overlapping peripheral surfaces between said peripheral portion of said active agent permeable membrane layer and said peripheral portion of said active agent impermeable barrier layer, and wherein said overlapping peripheral portions are heat sealed together to create an active agent impermeable seal surrounding said reservoir, whereby said active agent impermeable adhesive layer is applied to said active agent impermeable seal.
Claim 116
Dependent Claim
44 words
The device of claim 105 wherein said active agent impermeable barrier layer comprises a cover layer including an outer surface and an inner surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 117
Dependent Claim
32 words
The device of claim 97 wherein said temporary closure means comprises a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer.
Claim 118
Dependent Claim
50 words
The device of claim 109 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer, and wherein said first and second polymer layers comprise different polymers whereby said peelable heat seal is formed therebetween.
Claim 119
Dependent Claim
13 words
The device of claim 109 wherein said releasable surface comprises a siliconized coating.
Claim 120
Dependent Claim
31 words
The device of claim 111 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer.
Claim 121
Dependent Claim
16 words
The device of claim 112 wherein said first and second polymer layers comprise the same polymer.
Claim 122
Dependent Claim
53 words
The device of claim 110 wherein said first surface of said liner layer comprises a first polymer layer, said second surface of said liner layer comprises a paper layer, and said liner layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 123
Dependent Claim
53 words
The device of claim 114 wherein said first surface of said carrier layer comprises a first polymer layer, said second surface of said carrier layer comprises a paper layer, and said carrier layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer
Claim 124
Dependent Claim
32 words
The device of claim 115 wherein said temporary closure means comprises a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer
Claim 125
Independent Claim
447 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer and said active agent carrier, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location comprising a portion of said corresponding outer peripheries thereof, said film layer including a first surface and a second surface, and said first surface of said film layer being located on said first surface of said carrier layer at a location displaced from said hinge means, temporary closure means for temporarily sealing said first surface of said liner layer to said first surface of said liner layer to said first surface of said carrier layer at the remaining portion of said corresponding outer peripheries thereof, so as to provide a sealed container for said film layer and said active agent carrier therein, a first adhesive layer interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said portion of said carrier layer other than said hinge means is separated from said liner layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can simultaneously be removed from said carrier layer.
Claim 126
Independent Claim
447 words
A device for applying a film layer and an active agent carrier to the skin or mucosa of a patient comprising a liner layer including a first surface and a second surface, said first surface of said liner layer comprising a releasable surface, a carrier layer for said film layer and said active agent carrier, said carrier layer including a first surface and a second surface, said liner layer and said film layer having corresponding outer peripheries, hinge means permanently affixing said first surface of said liner layer to said first surface of said carrier layer at a predetermined location comprising a portion of said corresponding outer peripheries thereof, said film layer including a first surface and a second surface, and said first surface of said film layer being located on said first surface of said carrier layer at a location displaced from said hinge means, temporary closure means for temporarily sealing said first surface of said liner layer to said first surface of said liner layer to said first surface of said carrier layer at the remaining portion of said corresponding outer peripheries thereof, so as to provide a sealed container for said film layer and said active agent carrier therein, a first adhesive layer interposed between said first surface of said carrier layer and said first surface of said film layer for maintaining said film layer in contact with said carrier layer when said temporary closure means is unsealed and said portion of said carrier layer other than said hinge means is separated from said liner layer, and a second adhesive layer interposed between said first surface of said liner layer and said first surface of said carrier layer including said film layer and said active agent carrier for releasably maintaining said first surface of said carrier layer including said film layer and said active agent carrier in contact with said first surface of said liner layer, said second adhesive layer covering at least the entire periphery of said film layer, said first adhesive layer having a first coefficient of adhesion and said second adhesive layer having a second coefficient of adhesion, said first coefficient of adhesion of said carrier layer to said film layer being less than said second coefficient of adhesion of said film layer to said skin or mucosa of said patient, whereby upon application of said film layer and said active agent carrier to said skin or mucosa of said patient with said second adhesive layer therebetween, said film layer and said active agent carrier adhere to said skin or mucosa of said patient and said film layer and said active agent carrier can simultaneously be removed from said carrier layer.
Claim 127
Dependent Claim
86 words
The device of claim 117 wherein said active agent carrier comprises a reservoir containing said active agent, release means for the controlled release of said active agent from said reservoir, and an active agent impermeable barrier layer between said reservoir and said film layer, whereby said active agent may only be released from the inner surface of said reservoir towards said skin or mucosa of said patient upon application of aid film layer and said active agent carrier to said skin or mucosa of said patient.
Claim 128
Dependent Claim
44 words
The device of claim 118 wherein said release means comprises an active agent permeable membrane layer formed on said inner surface of said reservoir, whereby said reservoir is completely enclosed between said active agent permeable membrane layer and said active agent impermeable barrier layer.
Claim 129
Dependent Claim
37 words
The device of claim 119 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 130
Dependent Claim
60 words
The device of claim 120 wherein said second adhesive layer includes an active agent permeable adhesive portion and an active agent impermeable adhesive portion, said active agent permeable adhesive portion corresponding to said active agent permeable membrane layer and said active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 131
Dependent Claim
25 words
The device of claim 119 wherein said release means comprises a plurality of micro-capsules containing said active agent encapsulated by an active agent permeable membrane.
Claim 132
Dependent Claim
25 words
The device of claim 122 wherein said second adhesive layer includes an active agent permeable adhesive portion corresponding to said inner surface of said reservoir.
Claim 133
Dependent Claim
37 words
The device of claim 123 wherein said active agent impermeable barrier layer extends peripherally beyond said reservoir about the entire periphery thereof so as to create an extended peripheral area of said active agent impermeable barrier layer.
Claim 134
Dependent Claim
32 words
The device of claim 124 wherein said second adhesive layer includes an active agent impermeable adhesive portion corresponding to at least said extended peripheral area of said active agent impermeable barrier layer.
Claim 135
Dependent Claim
44 words
The device of claim 121 wherein said active agent impermeable barrier layer comprises a cover layer including an inner surface and an outer surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 136
Dependent Claim
86 words
The device of claim 121 wherein said active agent permeable membrane layer extends peripherally beyond said reservoir so as to provide at least a portion of overlapping peripheral surfaces between said peripheral portion of said active agent permeable membrane layer and said peripheral portion of said active agent impermeable barrier layer, and wherein said overlapping peripheral portions are heat sealed together to create an active agent impermeable seal surrounding said reservoir, whereby said active agent impermeable adhesive layer is applied to said active agent impermeable seal.
Claim 137
Dependent Claim
30 words
The device of claim 121 wherein said active agent impermeable adhesive layer comprises an adhesive composition selected from the group consisting of natural rubber adhesive, acrylic adhesives, and synthetic adhesives.
Claim 138
Dependent Claim
119 words
The device of claim 121 wherein said active agent permeable adhesive layer comprises an adhesive selected from the group consisting of acrylate and methacrylate resins; copolymers of acrylate or methacrylate, esters with acrylic acid, methacrylic acid, acrylamide, methacrylamides, N-alkoxymethyl acrylamides, N-alkoxymethyl methacrylamides, N-t-butylacrylamide, itaconic acid, vinyl acetate, N-branched alkyl maleamic acids wherein the alkyl group has 10 to 24 carbon atoms, glycol diacrylates, or mixture of these monomers; silicon rubber; styrenebutadiene rubber; butyl-ether rubber; neoprene rubber; nitrile rubber; polyisobutylene; polybutadiene; polyisoprene; polyurethane elastomers; polyvinyl alcohol; polyvinyl ethers; polyvinyl pyrrolidone; polyvinyl acetate; ureaformaldehyde resins; phenol formaldehyde resins; resorcinal formaldehyde resins; ethyl cellulose; methyl cellulose; nitrocellulose; cellulose acetate-butyrate; carboxymethyl cellulose; guar gum; acacia gum; pectina gum; starch; destria; gelatin; and casein.
Claim 139
Dependent Claim
31 words
The device of claim 119 wherein said active agent permeable membrane layer comprises a material selected from the group consisting of polypropylene, polycarbonates, polyvinyl chloride, cellulose acetate, cellulose nitrate and polyacrylonitrile.
Claim 140
Dependent Claim
46 words
The device of claim 117 wherein said active agent impermeable barrier layer comprises a material selected from the group consisting of cellophane, cellulose acetate, ethyl cellulose, plasticized vinyl acetate-vinyl chloride copolymers, ethylene-vinyl acetate copolymer, polyethylene terephthalate, nylon, polyethylene, polypropylene, polyvinylidene chloride, paper, cloth and aluminum foil.
Claim 141
Dependent Claim
30 words
The device of claim 126 wherein said cover layer is selected from the group consisting of a film of polyethylene terephthalate on polyethylene or a polyethylene/metallized polyethylene terephthalate/ polyethylene laminate.
Claim 142
Dependent Claim
20 words
The device of claim 117 wherein said active agent is selected from the group consisting of scopolamine, nitroglycerine and estradiol.
Claim 143
Dependent Claim
44 words
The device of claim 125 wherein said active agent impermeable barrier layer comprises a cover layer including an outer surface and an inner surface, and wherein said active agent impermeable adhesive layer is applied to substantially the entire inner surface of said cover layer.
Claim 144
Dependent Claim
30 words
The device of claim 125 wherein said active agent impermeable adhesive layer comprises an adhesive composition selected from the group consisting of natural rubber adhesives, acrylic adhesives, and synthetic adhesives.
Claim 145
Dependent Claim
119 words
The device of claim 125 wherein said active agent permeable adhesive layer comprises an adhesive selected from the group consisting of acrylate and methacrylate resins; copolymers of acrylate or methacrylate esters with acrylic acid, methacrylic acid, acrylamide, methacrylamides, N-alkoxymethyl acrylamides, N-alkoxymethyl methacrylamides, N-t-butylacrylamide, itaconic acid, vinylacetate, N-branched N-branched alkyl maleamic acids wherein the alkyl group has 10 to 24 carbon atoms, glycol diacrylates, or mixture of these monomers; silicon rubber; styrene-butadiene rubber; butyl-ether rubber; neoprene rubber; nitrile rubber; polyisobutylene; polybutadiene; polyisoprene; polyurethane elastomers; polyvinyl alcohol; polyvinyl ethers; polyvinyl pyrrolidone; polyvinyl acetate; ureaformaldehyde resins; phenol formaldehyde resins; resorcinal formaldehyde resins; ethyl cellulose; methyl cellulose; nitrocellulose; cellulose acetate-butyrate; carboxymethyl cellulose; guar gum; acacia gum; pectina gum; starch; destria; gelatin; and casein.
Claim 146
Dependent Claim
76 words
The device of claim 119 wherein said active agent permeable membrane layer is selected from the group consisting of polyvinyl chloride either unplasticized or plasticized with long-chain fattyamides, plasticized nylon, unplasticized soft nylon, silicone rubber, polyethylene, polyethylene terephthalate, polymerized esters of acrylic and methacrylic acid, modified collagent, cross-linked hydrophilic polyether gels, cross-linked polyvinyl alcohol, cross-linked partially hydrolyzed polyvinyl acetate, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, acacia gum, carboxymethyl cellulose, and carageenan alone or combined with gelatin.
Claim 147
Dependent Claim
30 words
The device of claim 126 wherein said cover layer is selected from the group consisting of a film of polyethylene terephthalate or polyethylene or a polyethylene/metallized polyethylene terephthalate/ polyethylene laminate.
Claim 148
Dependent Claim
32 words
The device of claim 118 wherein said temporary closure means comprises a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer.
Claim 149
Dependent Claim
50 words
The device of claim 134 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer, and wherein said first and second polymer layers comprise different polymers whereby said peelable heat seal is formed therebetween.
Claim 150
Dependent Claim
13 words
The device of claim 134 wherein said releasable surface comprises a siliconized coating.
Claim 151
Dependent Claim
31 words
The device of claim 141 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer.
Claim 152
Dependent Claim
16 words
The device of claim 142 wherein said first and second polymer layers comprise the same polymer.
Claim 153
Dependent Claim
53 words
The device of claim 135 wherein said first surface of said liner layer comprises a first polymer layer, said second surface of said liner layer comprises a paper layer, and said liner layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 154
Dependent Claim
53 words
The device of claim 144 wherein said first surface of said carrier layer comprises a first polymer layer, said second surface of said carrier layer comprises a paper layer, and said carrier layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 155
Dependent Claim
32 words
The device of claim 145 wherein said temporary closure means comprises a peelable heat seal formed between said first surface of said liner layer and said first surface of said carrier layer.
Claim 156
Dependent Claim
52 words
The device of claim 146 wherein said liner layer and said carrier layer each has a substantially square configuration, wherein said predetermined location for said hinge means comprises a first side of said square, and wherein said temporary closure means is located at the second, third and fourth sides of said square.
Claim 157
Dependent Claim
50 words
The device of claim 147 wherein said first surface of said liner layer comprises a first polymer layer and said second surface of said carrier layer comprises a second polymer layer, and wherein said first and second polymer layers comprise different polymers whereby said peelable heat seal is formed therebetween.
Claim 158
Dependent Claim
13 words
The device of claim 147 wherein said releasable surface comprises a siliconized coating.
Claim 159
Dependent Claim
31 words
The device of claim 149 wherein said first surface of said liner layer comprises a first polymer layer and said first surface of said carrier layer comprises a second polymer layer.
Claim 160
Dependent Claim
16 words
The device of claim 150 wherein said first and second polymer layers comprise the same polymer.
Claim 161
Dependent Claim
53 words
The device of claim 147 wherein said first surface of said liner layer comprises a first polymer layer, said second surface of said liner layer comprises a paper layer, and said liner layer includes an intermediate layer between said first surface and said second surface, said intermediate layer comprising a metallized film layer.
Claim 162
Dependent Claim
57 words
The device of claim 142 wherein said first surface of said carrier layer comprises a first polymer layer, said second surface of said carrier layer comprises a paper layer, and said carrier layer includes an intermediate layer between said first surface and said second surface of the carrier layer, said intermediate layer comprising a metallized film layer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-09 | 1993-10-09 | 1994-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-09 | 1997-10-09 | 1998-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-09 | 2001-10-09 | 2002-04-10 | $7700.00 | Window Closed / Lapsed |