US4914094A
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Method for treating hypoxia
Assignee: Otsuka Pharmaceutical Co Ltd
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Filing: 1989-03-21
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Granted: 1990-04-03
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Expires: 2009-03-21
Abstract
Abstract A method for curing and/or improving hypoxia characterized by administering a compound represented by the general formula (1), <IMAGE> (1) said compounds have been known in prior art literatures, for example, as carbostyril derivatives in Japanese Patent Kokai No. 54-160389 (1979), etc., as benzoxazine derivatives in Japanese Patent Kokai No. 59-70675 (1984), and as benzoazepine derivatives in Japanese Patent Kokai No. 57-193461 (1982), and they have been known as central nervous system controlling agents and antihistaminic agents. The present invention was established on the basis of the findings that the compounds represented by the general formula (1) possess excellent pharmacological activities for curing and/or improving hypoxia and also possess excellent anti-oxidative activities, which could not have been anticipated from the disclosures in the prior art literatures.
Inventors
- 👤 Yasuo Oshiro
- 👤 Masaaki Osaki
- 👤 Tetsuro Kikuchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:36
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/435; A61K31/47; A61K31/535; A61K31/54; A61K31/55
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
235 words
A method for treating hypoxia comprising, administering to a host in need of said treatment a compound or salt thereof represented by formula (1), ##STR13## wherein R 1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group; Z is a group of the formula ##STR14## in which R 2 is a hydrogen atom or a lower alkyl group; and the bond indicated as is a single or double bond, a group of the formula --(CH 2 ) 3 --, a group of the formula --O--CH 2 -- or a group of the formula --S--CH 2 --; R 3 is a pyridyl group, or a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group and a hydroxy group; and a group of the formula ##STR15## is a group of the formula ##STR16## and A is a lower alkylene group; provided that when a group of the formula ##STR17## is a group of the formula ##STR18## then Z is a group of the formula ##STR19## and at the same time R 3 should be neither a pyridyl group nor a phenyl group having at least one hydroxy group as the substituent; or when R 3 is a pyridyl group, then Z is a group of the formula ##STR20##
Claim 2
Independent Claim
235 words
A method for treating hypoxia comprising, administering to a host in need of said treatment a compound or salt thereof represented by formula (1), ##STR13## wherein R 1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group; Z is a group of the formula ##STR14## in which R 2 is a hydrogen atom or a lower alkyl group; and the bond indicated as is a single or double bond, a group of the formula --(CH 2 ) 3 --, a group of the formula --O--CH 2 -- or a group of the formula --S--CH 2 --; R 3 is a pyridyl group, or a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group and a hydroxy group; and a group of the formula ##STR15## is a group of the formula ##STR16## and A is a lower alkylene group; provided that when a group of the formula ##STR17## is a group of the formula ##STR18## then Z is a group of the formula ##STR19## and at the same time R 3 should be neither a pyridyl group nor a phenyl group having at least one hydroxy group as the substituent; or when R 3 is a pyridyl group, then Z is a group of the formula ##STR20##
Claim 3
Dependent Claim
52 words
The method according to claim 1, wherein R 3 in the general formula (1) is a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 alkoxy group and a hydroxy group.
Claim 4
Dependent Claim
52 words
The method according to claim 2, wherein R 3 in the general formula (1) is a phenyl group which may have 1 to 2 substituents selected from the group consisting of a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 alkoxy group and a hydroxy group.
Claim 5
Dependent Claim
45 words
The method according to claim 3, wherein Z in the general formula (1) is a group of the formula ##STR21## (wherein R 2 is a hydrogen atom or a C 1 -C 6 alkyl group; and the bond indicated as is the same defined above).
Claim 6
Dependent Claim
18 words
The method according to claim 4, wherein R 2 in the general formula (1) is a hydrogen atom.
Claim 7
Dependent Claim
22 words
The method according to claim 3, wherein Z in the general formula (1) is a group of the formula --O--CH 2 --.
Claim 8
Dependent Claim
33 words
The method according to claim 3, wherein Z in the general formula (1) is a group of the formula --(CH 2 ) 3 -- or a group of the formula --S--CH 2 --.
Claim 9
Independent Claim
29 words
The method according to claims 5, 6 or 7, wherein R 1 in the general formula (1) is a hydrogen atom or a C 1 -C 6 alkyl group.
Claim 10
Dependent Claim
18 words
The method according to claim 1, wherein R 3 in the general formula (1) is a pyridyl group.
Claim 11
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(4-Methylphenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
Claim 12
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(4-Methylphenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
Claim 13
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 6-{3-[4-(3-(Methylphenyl)-1-piperazinyl]propoxy}-2H-1,4-benzoxazin-3(4H)-one or a salt thereof in an amount effective for said treatment.
Claim 14
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 6-{3-[4-(3-(Methylphenyl)-1-piperazinyl]propoxy}-2H-1,4-benzoxazin-3(4H)-one or a salt thereof in an amount effective for said treatment.
Claim 15
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(3-Chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
Claim 16
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(3-Chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
Claim 17
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(3-Methylphenyl)-1,2,5,6-tetrahydro-1-pyridyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
Claim 18
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(3-Methylphenyl)-1,2,5,6-tetrahydro-1-pyridyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
Claim 19
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 6-{3-[4-(2,3-Dimethylphenyl)-1-piperazinyl]propoxy-}-2H-1,4-benzoazine-3(4H)-one or a salt thereof in an amount effective for said treatment.
Claim 20
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 6-{3-[4-(2,3-Dimethylphenyl)-1-piperazinyl]propoxy-}-2H-1,4-benzoazine-3(4H)-one or a salt thereof in an amount effective for said treatment.
Claim 21
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(4-Chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
Claim 22
Independent Claim
27 words
A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(4-Chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
References Cited (Backward Citations)
US4154832A
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US4734416A
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JPS55124766A
Cited
JPS5649361A
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JPS57145872A
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JPS57193461A
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JPS5967565A
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