US4914084A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
Assignee: Quixote Corp
•
Filing: 1987-03-26
•
Granted: 1990-04-03
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Expires: 2007-03-26
Abstract
Abstract A liquid coacervate composition and a method of introducing heme, hemoproteins and/or heme-hemoprotein complexes into the body. The liquid composition, comprising an oxygen-carrying molecule containing iron and a two-phase aqueous coacervate system, can be administered orally or intraveneously. The liquid composition is utilized to augment the oxygen transport capability of the body, to treat for several of the anemias and/or to act as an oxygen-carrying plasma volume extender.
Inventors
- 👤 Bernard Ecanow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5089; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
97 words
A method of stabilizing a solution of an iron-containing molecule capable of carrying and releasing oxygen comprising intimately contact the solution with a chemical agent capable of forming a complex with iron prior to coacervation to complex substantially all of the iron-containing molecules with said chemical agent, in solution, with said chemical agent; thereafter, intimately contacting the solution with an interactant capable of interacting with said chemical agent, as complexed with the iron-containing molecules in solution, to release said chemical agent from solution; and including the iron-containing molecule within a coacervate phase of a two-phase coacervate composition.
Claim 2
Independent Claim
97 words
A method of stabilizing a solution of an iron-containing molecule capable of carrying and releasing oxygen comprising intimately contact the solution with a chemical agent capable of forming a complex with iron prior to coacervation to complex substantially all of the iron-containing molecules with said chemical agent, in solution, with said chemical agent; thereafter, intimately contacting the solution with an interactant capable of interacting with said chemical agent, as complexed with the iron-containing molecules in solution, to release said chemical agent from solution; and including the iron-containing molecule within a coacervate phase of a two-phase coacervate composition.
Claim 3
Dependent Claim
33 words
The method of claim 1 wherein the iron-containing molecule capable of carrying and releasing oxygen is selected from the group consisting of heme, a hemoprotein, and a mixture of heme and a hemoprotein.
Claim 4
Dependent Claim
13 words
The method of claim 1 wherein the chemical agent is gaseous carbon monoxide.
Claim 5
Dependent Claim
35 words
The method of claim 3 wherein the solution intimately contacted the carbon monoxide by bubbling carbon monoxide through the solution until substantially all of the iron in the iron-containing molecules are complexed with carbon monoxide.
Claim 6
Dependent Claim
10 words
The method of claim 1 wherein the interactant comprises oxygen.
Claim 7
Dependent Claim
31 words
The method of claim 5 wherein the solution is intimately contacted with oxygen by bubbling oxygen through the solution until substantially all of the complexed carbon monoxide is replaced by oxygen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-02 | 1993-10-02 | 1994-04-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-02 | 1997-10-02 | 1998-04-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-02 | 2001-10-02 | 2002-04-03 | $7700.00 | Window Closed / Lapsed |