US4911710A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of collagenous tissue
Assignee: Domedica Pty Ltd
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Filing: 1986-11-13
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Granted: 1990-03-27
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Expires: 2006-11-13
Abstract
Abstract An implantable collagen-based material is prepared by (i) pretreating a collagen-based material with a member selected from the group consisting of fluorescein isothiocyanate, picrylsulphonic acid and nitrous acid, in an amount sufficient to render some of the amino acid side chains of the material unable to bind with a cross-linking agent, and (ii) reacting the pretreated collagen-based material with a cross-linking agent whereby at least some of the remaining amino acid side chains are linked together.
Inventors
- 👤 Bruce Milthorpe
- 👤 Klaus Schindhelm
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:18
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3695; A61L17/00; A61L17/06; A61L17/08; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/92; Y10S623/922
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
79 words
A process for preparing an implantable collagen-based material which comprises: (i) pretreating a collagen-based material with a member selected from the group consisting of fluorescein isothiocyanate, picrylsulphonic acid and nitrous acid, in an amount sufficient to render some of the amino acid side chains of the material unable to bind with a cross-linking agent, and (ii) reacting the pretreated collagen-based material with a cross-linking agent whereby at least some of the remaining amino acid side chains are linked together.
Claim 2
Dependent Claim
79 words
A process for preparing an implantable collagen-based material which comprises: (i) pretreating a collagen-based material with a member selected from the group consisting of fluorescein isothiocyanate, picrylsulphonic acid and nitrous acid, in an amount sufficient to render some of the amino acid side chains of the material unable to bind with a cross-linking agent, and (ii) reacting the pretreated collagen-based material with a cross-linking agent whereby at least some of the remaining amino acid side chains are linked together.
Claim 3
Dependent Claim
64 words
A process according to claim 1, wherein said pretreating is carried out with a member selected from the group consisting of fluorescein isothiocyanate or picrylsulphonic acid, at a concentration of 100 to 2000 milligrams per liter at a temperature of from -15° C. to 60° C., and wherein the amount of collagen-based material ranges from 20 to 250 grams per liter of pretreatment agent.
Claim 4
Dependent Claim
29 words
A process according to claim 1 wherein the collagenous material is selected from the group comprising ligaments, tendons, heart valves, dura mater, pericardium skin patches, blood vessels and ureters.
Claim 5
Dependent Claim
22 words
A process according to claim 3 wherein the collagen-based material is selected from the animal source bovine, porcine, ovine, equine and kangaroo.
Claim 6
Dependent Claim
28 words
A process according to claim 1 wherein the cross-linking agent is selected from the group comprising glutaraldehyde, glyoxal, malonaldehyde, succinaldehyde, adipaldehyde, dialdehyde starch, adipyldichloride, formaldehyde, acrolein and acetaldehyde.
Claim 7
Dependent Claim
14 words
An implantable collagen-based material prepared in accordance with the process claimed in claim 9.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-26 | 1993-09-25 | 1994-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-26 | 1997-09-25 | 1998-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-26 | 2001-09-25 | 2002-03-27 | $7700.00 | Window Closed / Lapsed |