US4906477A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antineoplastic agent-entrapping liposomes
Assignee: VITAMIN KENKYUSYO KK
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Filing: 1988-02-08
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Granted: 1990-03-06
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Expires: 2008-02-08
Abstract
Abstract Some of antineoplastic agents, for instance, adriamycin and daunorubicin, have a positive charge at physiological pH. Such drugs possess high affinity for binding to steroidal sulfate by means of electrostatic force. The invention utilizes this property to prepare steroidal sulfate liposomes having a net negative charge and encapsulating the antineoplastic agent.
Inventors
- 👤 Masayasu Kurono
- 👤 Hitoshi Noda
- 👤 Tomio Ogasawara
- 👤 Hidefumi Yamakawa
- 👤 Takafumi Iida
- 👤 Kunio Yagi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 05:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K9/1272; A61P; A61P35/00; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
29 words
An antineoplastic composition comprising a liposome, the lipids constituting the liposome consisting essentially of phosphatidylcholine, cholesterol and a steroidal sulfate ester; and an antineoplastic agent entrapped in the liposome.
Claim 2
Dependent Claim
29 words
An antineoplastic composition comprising a liposome, the lipids constituting the liposome consisting essentially of phosphatidylcholine, cholesterol and a steroidal sulfate ester; and an antineoplastic agent entrapped in the liposome.
Claim 3
Dependent Claim
14 words
A composition according to claim 1, wherein the steroid sulfate ester is cholesterol sulfate.
Claim 4
Dependent Claim
12 words
A composition according to claim 1, wherein the antineoplastic agent is adriamycin.
Claim 5
Dependent Claim
12 words
A composition according to claim 2, wherein the antineoplastic agent is adriamycin.
References Cited (Backward Citations)
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Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-05 | 1993-09-04 | 1994-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-05 | 1997-09-04 | 1998-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-05 | 2001-09-04 | 2002-03-06 | $7700.00 | Window Closed / Lapsed |