US4906473A
Expired / Lapsed
US
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Biodegradable poly(hydroxyalkyl)amino dicarboxylic acid) derivatives, a process for their preparation, and the use thereof for depot formulations with controlled delivery of active ingredient
Assignee: Hoechst AG
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Filing: 1987-12-31
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Granted: 1990-03-06
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Expires: 2007-12-31
Abstract
Abstract The invention relates to biodegradable poly((hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I <IMAGE> (I) <IMAGE> in which n, m, x, y, z, R and R' have the indicated meanings, and to a process for their preparation and to the use thereof for depot formulations with controlled delivery of active ingredient.
Inventors
- 👤 Hubert Bader
- 👤 Diether Ruppel
- 👤 Axel Walch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 01:05
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/02; C08G69/08; C08G69/10; A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/2045; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
115 words
Poly((hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I ##STR6## in which n is 1 or 2, m is 2 to 6, x and y are 1 to 400, and z is 0 to 40, and in which the radicals R and R' are identical or, independently of one another, different and denote branched or unbranched, saturated or unsaturated alkyl, cycloalkyl, alkoxy or cycloalkyloxy groups having a total of 1-22 carbon atoms in the alkyl moiety, it being possible for the alkyl moiety optionally to be interrupted by a carbonyloxy group, or biologically inactive steroid alcohols bonded via their hydroxyl groups, there being random distribution in the polymer of the monomer units placed in square brackets.
Claim 2
Dependent Claim
115 words
Poly((hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I ##STR6## in which n is 1 or 2, m is 2 to 6, x and y are 1 to 400, and z is 0 to 40, and in which the radicals R and R' are identical or, independently of one another, different and denote branched or unbranched, saturated or unsaturated alkyl, cycloalkyl, alkoxy or cycloalkyloxy groups having a total of 1-22 carbon atoms in the alkyl moiety, it being possible for the alkyl moiety optionally to be interrupted by a carbonyloxy group, or biologically inactive steroid alcohols bonded via their hydroxyl groups, there being random distribution in the polymer of the monomer units placed in square brackets.
Claim 3
Dependent Claim
66 words
Poly((hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I as claimed in claim 1, in which n is 1 and m is 2, and the radicals R and R' are identical or, independently of one another, different and denote unbranched alkyl or alkoxy groups having 1-22 carbon atoms in the alkyl moiety, it being possible for the alkyl moiety optionally to be interrupted by a carbonyloxy group.
Claim 4
Dependent Claim
38 words
Poly(hydroxyalkylamino dicarboxylic acid) derivatives of the formula I as claimed in claim 1, in which n is 1 and m is 2, and R is a methyl or methoxy group, and R' is a pentyl- or butyloxycarbonylethyl group.
Claim 5
Dependent Claim
64 words
A process for the preparation of poly(hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I, which comprises reaction of a poly(hydroxyalkylamino dicarboxylic acid) of the formula IIa ##STR7## with one or more different compounds of the formula III ##STR8## n, m, x, y, z, R and R' having the meanings indicated for formula I in claim 1, and X being chlorine, bromine, iodine or hydroxyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-05 | 1993-09-04 | 1994-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-05 | 1997-09-04 | 1998-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-05 | 2001-09-04 | 2002-03-06 | $7700.00 | Window Closed / Lapsed |